1st Edition

Nanomedicines and Nanoproducts Applications, Disposition, and Toxicology in the Human Body

By Eiki Igarashi Copyright 2015
    259 Pages 37 Color & 46 B/W Illustrations
    by CRC Press

    259 Pages 37 Color & 46 B/W Illustrations
    by CRC Press

    259 Pages 37 Color & 46 B/W Illustrations
    by CRC Press

    Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.

    Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:

    • Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
    • Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
    • Describes the intravenous route of administration for the therapeutic management of ocular disease
    • Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
    • Summarizes various toxicological principles and the testing of nanoproducts

    Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book’s goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

    Nanoscale World
    Scope of Nanoproducts
    Disposition of Nanoproducts and Nanoparticles
    Polydispersity of Nanoparticles and Penetration Barriers in the Body
    Physicochemical Properties of Nanoparticles
    History of Nanotechnology and Nanomedicine
    Overview of the Nanoscale World
    Overview of Nanoproduct Disposition
    Pathways for Nanoproduct Absorption, Distribution, and Excretion
    Liberation, Absorption, Distribution, Metabolism, and Excretion
    Volume of Distribution
    Respiratory and Olfactory Routes
    Anatomy and Physiology
    Practical Application of Biodegradable Nanomedicines
    Practical Application of Nonbiodegradable Nanomedicines
    Inhalation of Nanoproducts
    Transport and Liberation of Inhaled Products
    Absorption via the Alveoli
    Distribution and Translocation
    Disposition of Nanomedicines from the Nasal Cavity to Systemic Tissues
    Clearance of Nanoparticles
    Nanoscale World according to the Respiratory and Olfactory Routes
    Buccal Route and Ingestion
    Anatomy and Physiology
    Factors Affecting Nanoparticle Disposition
    Practical Applications of Nanoproducts
    Risks and Benefits of Nanoscale Food Packaging Products and Nanofoods
    Bioavailability of Nanomedicines and Nanofoods
    Cellular Endocytosis of Nanoparticles
    Disposition of Nanoparticles Following Oral Administration
    Nanoscale World via the Buccal Route and Ingestion
    The Integumentary System and the Ocular Route
    Anatomy and Physiology
    Practical Applications in Skin Care
    Practical Applications in Ocular Medical Care
    Exposure to Sunlight and Nanoparticle Toxicity
    Factors Affecting Permeability and Disposition in the Integumentary System
    Nanoscale World via the Integumentary System and the Ocular Route
    Systemic Route
    Anatomy and Physiology
    Pathway from Systemic Exposure to Local Delivery
    Endocytosis of Nanoparticles
    Nuclear Transport
    Cell Transition/Translocation
    Practical Application of Nanomedicines
    Engineering of Nanomedicines
    Engineering of Nanoproducts Targeting Disease
    Nanoscale World via the Systemic Route
    Toxicology in the Nanoscale World
    Characteristics of Exposure
    Spectrum of Undesired Effects
    Dose-Response Relationships
    Descriptive Animal Toxicity Tests
    Nanoproduct Compatibility with the Immune System


    Eiki Igarashi is CEO of Nanosion Co., Ltd., a nanobioventure company in Tokyo, Japan. He is also a guest investigator at the National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, where he collects and reviews medical information regarding the practical application, toxicology, and pharmacokinetics of nanoproducts and nanomaterials, ranging from metallic nanoparticles and carbon nanotubes to nanomedicines, nanofoods, nanocosmeceuticals, and nanoconsumer products. He holds a doctoral degree from Hiroshima University, Japan, and has worked in various capacities with Marion Merrell Dow Co., Ltd. (the pharmaceutical company of the Dow Chemical Company), Hirakata, Japan; Kyoto University, Japan; and Hoechst Marion Roussel Co., Ltd., Tokyo, Japan.

    "… a comprehensive text for all nanoscientists … [that] deals extensively with nanoparticles ranging from organic (liposomes, micelles, and nanocrystals) to nondegradable organic (carbon nanotube) and inorganic (gold, silver, and titanium), and is very useful to understand widely the drug delivery systems of nanoparticles."
    —Kazuhiro Kagami, Activus Pharma Co., Ltd., Tokyo, Japan