Nanomedicines and Nanoproducts : Applications, Disposition, and Toxicology in the Human Body book cover
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Nanomedicines and Nanoproducts
Applications, Disposition, and Toxicology in the Human Body





ISBN 9781138749160
Published October 27, 2017 by CRC Press
259 Pages 37 Color & 46 B/W Illustrations

 
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Book Description

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.

Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:

  • Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
  • Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
  • Describes the intravenous route of administration for the therapeutic management of ocular disease
  • Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
  • Summarizes various toxicological principles and the testing of nanoproducts

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book’s goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

Table of Contents

Nanoscale World
Scope of Nanoproducts
Disposition of Nanoproducts and Nanoparticles
Polydispersity of Nanoparticles and Penetration Barriers in the Body
Physicochemical Properties of Nanoparticles
History of Nanotechnology and Nanomedicine
Overview of the Nanoscale World
References
Overview of Nanoproduct Disposition
Pathways for Nanoproduct Absorption, Distribution, and Excretion
Liberation, Absorption, Distribution, Metabolism, and Excretion
Liberation
Bioavailability
Volume of Distribution
Clearance
References
Respiratory and Olfactory Routes
Anatomy and Physiology
Practical Application of Biodegradable Nanomedicines
Practical Application of Nonbiodegradable Nanomedicines
Inhalation of Nanoproducts
Transport and Liberation of Inhaled Products
Absorption via the Alveoli
Distribution and Translocation
Disposition of Nanomedicines from the Nasal Cavity to Systemic Tissues
Clearance of Nanoparticles
Nanoscale World according to the Respiratory and Olfactory Routes
References
Buccal Route and Ingestion
Anatomy and Physiology
Factors Affecting Nanoparticle Disposition
Practical Applications of Nanoproducts
Risks and Benefits of Nanoscale Food Packaging Products and Nanofoods
Bioavailability of Nanomedicines and Nanofoods
Cellular Endocytosis of Nanoparticles
Disposition of Nanoparticles Following Oral Administration
Nanoscale World via the Buccal Route and Ingestion
References
The Integumentary System and the Ocular Route
Anatomy and Physiology
Practical Applications in Skin Care
Practical Applications in Ocular Medical Care
Exposure to Sunlight and Nanoparticle Toxicity
Factors Affecting Permeability and Disposition in the Integumentary System
Nanoscale World via the Integumentary System and the Ocular Route
References
Systemic Route
Anatomy and Physiology
Pathway from Systemic Exposure to Local Delivery
Endocytosis of Nanoparticles
Nuclear Transport
Cell Transition/Translocation
Practical Application of Nanomedicines
Engineering of Nanomedicines
Engineering of Nanoproducts Targeting Disease
Nanoscale World via the Systemic Route
References
Toxicology in the Nanoscale World
Characteristics of Exposure
Spectrum of Undesired Effects
Tolerance
Dose-Response Relationships
Descriptive Animal Toxicity Tests
Nanoproduct Compatibility with the Immune System
References

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Author(s)

Biography

Eiki Igarashi is CEO of Nanosion Co., Ltd., a nanobioventure company in Tokyo, Japan. He is also a guest investigator at the National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, where he collects and reviews medical information regarding the practical application, toxicology, and pharmacokinetics of nanoproducts and nanomaterials, ranging from metallic nanoparticles and carbon nanotubes to nanomedicines, nanofoods, nanocosmeceuticals, and nanoconsumer products. He holds a doctoral degree from Hiroshima University, Japan, and has worked in various capacities with Marion Merrell Dow Co., Ltd. (the pharmaceutical company of the Dow Chemical Company), Hirakata, Japan; Kyoto University, Japan; and Hoechst Marion Roussel Co., Ltd., Tokyo, Japan.

Reviews

"… a comprehensive text for all nanoscientists … [that] deals extensively with nanoparticles ranging from organic (liposomes, micelles, and nanocrystals) to nondegradable organic (carbon nanotube) and inorganic (gold, silver, and titanium), and is very useful to understand widely the drug delivery systems of nanoparticles."
—Kazuhiro Kagami, Activus Pharma Co., Ltd., Tokyo, Japan