Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body, 1st Edition (Paperback) book cover

Nanomedicines and Nanoproducts

Applications, Disposition, and Toxicology in the Human Body, 1st Edition

By Eiki Igarashi

CRC Press

259 pages | 37 Color Illus. | 46 B/W Illus.

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Description

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.

Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:

  • Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
  • Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
  • Describes the intravenous route of administration for the therapeutic management of ocular disease
  • Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
  • Summarizes various toxicological principles and the testing of nanoproducts

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book’s goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

Reviews

"… a comprehensive text for all nanoscientists … [that] deals extensively with nanoparticles ranging from organic (liposomes, micelles, and nanocrystals) to nondegradable organic (carbon nanotube) and inorganic (gold, silver, and titanium), and is very useful to understand widely the drug delivery systems of nanoparticles."

—Kazuhiro Kagami, Activus Pharma Co., Ltd., Tokyo, Japan

Table of Contents

Nanoscale World

Scope of Nanoproducts

Disposition of Nanoproducts and Nanoparticles

Polydispersity of Nanoparticles and Penetration Barriers in the Body

Physicochemical Properties of Nanoparticles

History of Nanotechnology and Nanomedicine

Overview of the Nanoscale World

References

Overview of Nanoproduct Disposition

Pathways for Nanoproduct Absorption, Distribution, and Excretion

Liberation, Absorption, Distribution, Metabolism, and Excretion

Liberation

Bioavailability

Volume of Distribution

Clearance

References

Respiratory and Olfactory Routes

Anatomy and Physiology

Practical Application of Biodegradable Nanomedicines

Practical Application of Nonbiodegradable Nanomedicines

Inhalation of Nanoproducts

Transport and Liberation of Inhaled Products

Absorption via the Alveoli

Distribution and Translocation

Disposition of Nanomedicines from the Nasal Cavity to Systemic Tissues

Clearance of Nanoparticles

Nanoscale World according to the Respiratory and Olfactory Routes

References

Buccal Route and Ingestion

Anatomy and Physiology

Factors Affecting Nanoparticle Disposition

Practical Applications of Nanoproducts

Risks and Benefits of Nanoscale Food Packaging Products and Nanofoods

Bioavailability of Nanomedicines and Nanofoods

Cellular Endocytosis of Nanoparticles

Disposition of Nanoparticles Following Oral Administration

Nanoscale World via the Buccal Route and Ingestion

References

The Integumentary System and the Ocular Route

Anatomy and Physiology

Practical Applications in Skin Care

Practical Applications in Ocular Medical Care

Exposure to Sunlight and Nanoparticle Toxicity

Factors Affecting Permeability and Disposition in the Integumentary System

Nanoscale World via the Integumentary System and the Ocular Route

References

Systemic Route

Anatomy and Physiology

Pathway from Systemic Exposure to Local Delivery

Endocytosis of Nanoparticles

Nuclear Transport

Cell Transition/Translocation

Practical Application of Nanomedicines

Engineering of Nanomedicines

Engineering of Nanoproducts Targeting Disease

Nanoscale World via the Systemic Route

References

Toxicology in the Nanoscale World

Characteristics of Exposure

Spectrum of Undesired Effects

Tolerance

Dose-Response Relationships

Descriptive Animal Toxicity Tests

Nanoproduct Compatibility with the Immune System

References

About the Author

Eiki Igarashi is CEO of Nanosion Co., Ltd., a nanobioventure company in Tokyo, Japan. He is also a guest investigator at the National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, where he collects and reviews medical information regarding the practical application, toxicology, and pharmacokinetics of nanoproducts and nanomaterials, ranging from metallic nanoparticles and carbon nanotubes to nanomedicines, nanofoods, nanocosmeceuticals, and nanoconsumer products. He holds a doctoral degree from Hiroshima University, Japan, and has worked in various capacities with Marion Merrell Dow Co., Ltd. (the pharmaceutical company of the Dow Chemical Company), Hirakata, Japan; Kyoto University, Japan; and Hoechst Marion Roussel Co., Ltd., Tokyo, Japan.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI010000
SCIENCE / Biotechnology
TEC021000
TECHNOLOGY & ENGINEERING / Material Science