1st Edition

Nanoparticles in Cancer Theranostics Current Progress in Cancer Management

    340 Pages 77 Color & 6 B/W Illustrations
    by CRC Press

    This book comprehensively reviews the application of nanoparticles in cancer diagnosis and treatment. The introductory section provides a fundamental understanding of cancer biology, its global incidence and prevalence, and the intricate nano-bio interactions at the cellular level. The subsequent section discusses the pivotal role of nanoparticles in precise cancer detection, enhancing cancer imaging, and serving as contrast agents for accurate diagnosis. It also presents cutting-edge nanotechnology-based methods for detecting HTLV-1 retroviruses. The following section covers the utilization of lipid-based nanoparticles, monoclonal antibodies, and advanced nanotherapeutics for targeted cancer treatments. The chapters also explore polymeric nanoparticles for cancer vaccines, membrane-based nano-vaccines, and gene therapy approaches employing nanoparticles. The book further examines the application of nanotechnology in radiotherapy, phototherapy modalities, and strategies to overcome drug resistance. Additionally, it addresses chemodynamic nanoparticles for theranostics and the use of bioengineered virus-like nanoparticles in diagnostics and therapeutics. In the concluding sections, the book discusses the current status of anti-cancer nanotherapeutics in clinical trials and the challenges and future prospects of nanoparticle applications. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.

    Part I: Introduction                                                                                                              

    Chapter 1. An Introduction to Fundamentals of Cancer Cell Biology                                               

    Neelam Thakur and Prudhvi Lal Bhukya


    Chapter 2. Recent Patterns of Cancer Incidence and Mortality: Global and Indian Scenario

    Sunita Saklani


    Chapter 3. Nano-Bio Dynamics: Mechanisms and Challenges in Shaping Nanomaterials for Biomedical Use

    Gagandeep Singh, L Preethi, and Neelam Thakur


    Part II: Nanoparticles in Cancer Diagnosis

    Chapter 4. Conventional Methods of Cancer Diagnosis

    Sunita Saklani     


    Chapter 5. Uncovering the Impact of Nanoparticles in Cancer Diagnosis

    Priyanka Chambial, Asvin Suresh Babu and Neelam Thakur


    Chapter 6. Nano Contrast Agents: Illuminating Cancer Pathways for Precise Diagnosis

    Gagandeep Singh, Arshiya Sood and Neelam Thakur


    Chapter 7. Cancer Imaging Enhancement through Nanotechnology

    Samjeet Singh Thakur and Bhagwati Prashad Sharma


    Chapter 8. Cancer Detection: Nanodevices at the Forefront of Early Diagnosis

    Arshiya Sood, Ishant Arora and Neelam Thakur


    Part III: Nanoparticles in Cancer Therapy

    Chapter 9. Conventional Methods of Cancer Therapy

    Priyanka Chambial, Prudhvi Lal Bhukya, Vidushi Bahl and Neelam Thakur


    Chapter 10. Exploring the Nanoparticles in Cancer treatment

    Priyanka Chambial, Christy Thomas, and Neelam Thakur


    Chapter 11. Lipid-based Nanoparticles to Diagnose and Cure Cancer

    Anju Singh and Kamal Kishor Thakur


    Chapter 12. Multifunctional Nanomaterials for Advanced Cancer Therapy

     Akriti Sharma, Arundhati and Divya Dhawal Bhandari


    Chapter 13. Monoclonal Antibodies for Targeted Drug Delivery

    Sujata Adhana, Jyoti Chaudhary, Anil Kumar Mavi


    Chapter 14. Nanoparticles in Immunotherapy for Viral-Related Cancers

    Akash Tripathi Satsangi, Soumya Upadhyay, Jyoti and Anil Kumar Mavi


    Chapter 15. Sequential Catalytic Nanomedicine-enabled Chemotherapy-based Synergetic Cancer Treatments

    Priyanka Chambial, Rhea Vas and Neelam Thakur


    Chapter 16. Strategies Using Nanomedicine to Manage Drug Resistance in Cancer

    Divya Dhawal Bhandari, Anuradha Derashri, Nitin Kolhe, Akanksha Dwivedi, Hitesh Chopra, Akriti Sharma and Arundhati


    Dr. Neelam Thakur has been serving as an Assistant Professor in the Department of Zoology at Sardar Patel University, Mandi, Himachal Pradesh, since the year 2022. She also holds the roles of Coordinator and Head of the Zoology Department at the same institution. Prior to her tenure at Sardar Patel University, she worked as an Associate Professor in the Department of Biosciences at Chandigarh University in Punjab. Dr. Thakur earned her Ph.D. in Genetics from Himachal Pradesh University in 2012. Following the completion of her Ph.D., she joined the Immunology lab at CSIR-Imtech, Chandigarh, as a Research Associate in 2012. Her research interests encompass various fields, including early diagnosis of tuberculosis and cancer, nanotechnology for cancer diagnostics and therapy, cytogenetic analysis of intellectually disabled individuals, and microbiome studies. She has a substantial research track record, having published more than 20 research papers in international journals of high repute. Additionally, she holds a patent titled Antigenic composition and method of expression thereof. Dr. Thakur has been recognized for her contributions to research with two Young Researchers Awards and one Eminent Researchers Award from government-registered societies and organizations.

     Dr. Prudhvi Lal Bhukya is a Virologist currently serving as a Scientist at the ICMR-National Animal Resource Facility for Biomedical Research (NARFBR) in Hyderabad. Presently, he heads the Vaccine Testing Facility at NARFBR. His areas of expertise include preclinical vaccinology studies, host-viral interaction studies of emerging human viral infections, and the prevention and control of diseases, along with the development of tools to prevent outbreaks. He earned his Ph.D. from the ICMR-National Institute of Virology-Pune, focusing on the human hepatitis B virus. He has established his credentials through his work on HBV and HEV, as evidenced by his publication record. Dr. Bhukya has presented his research at numerous national and international conferences. His achievements include several publications in international journals of high repute.