1st Edition

Nanoparticles in Cancer Therapy Innovations and Clinical Applications

Edited By Neelam Thakur, Bhukya Prudhvi Lal Copyright 2025
    400 Pages 97 Color & 1 B/W Illustrations
    by CRC Press

    This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis, and the development of therapeutic strategies. The first section introduces the fundamentals of cancer biology alongside the various nanoparticles utilized in cancer therapy. The second section discusses the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy, and gene therapy techniques employing nanoparticles. The third section presents the advanced nanomedicine approaches, detailing the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials, and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities, and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The final sections review the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine, and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.

    Chapter 1. Introduction to Cancer Biology. Chapter 2. Nanoparticles used in cancer therapy. Part II: Nanoparticles in Cancer Vaccines and Gene Therapy. Chapter 3. Polymeric nanoparticles as nanovaccine carriers for eliciting anticancer immunity. Chapter 4. Membrane-Based Nano-Vaccines for Immunotherapy. Chapter 5. Gene Therapy Utilizing Nanoparticles. Part III: Advanced Nanomedicine Approaches. Chapter 6. From Diagnosis to Treatment: The Role of Chemodynamic Nanoparticles in Cancer Theranostics. Chapter 7. Low-Dimensional Nanomaterials as an Emerging Platform for Cancer Diagnosis and Therapy. Chapter 8. Emerging Nano-based Strategies for Managing Drug Resistance in Cancer. Chapter 9. Nanotechnology-based Radiation Therapy to Cure Cancer. Chapter 10. Phototherapy Modalities Empowered by Nanotechnology. Chapter 11. Bioengineered Virus-Like Nanoparticles for Cancer Diagnostics and Therapeutics. Part IV: Clinical Applications and Future Prospects. Chapter 12. Theranostic Nanoparticles: Revolutionizing Cancer Diagnosis and Treatment. Chapter 13. Anti-Cancer Nanotherapeutics in Clinical Trials: The Work Behind Clinical Translation of Nanomedicine. Chapter 14. Limitations of Cancer Nanotherapy: Present Status and Future Prospects. Chapter 15. Current Challenges and Future Prospects in Nanoparticle Application. Chapter 16. Assessment of Genotoxicity and Immunotoxicity Nanoparticles: Overview and testing methods. Chapter 17. Assessment of Nanoparticles Induced Cytotoxicity and Safety Profiles. Chapter 18. Nanotechnology in Cancer Therapy: Targeted Drug Delivery and the Role in Viral Oncogenesis

    Biography

    Dr. Prudhvilal Bhukya is a Virologist currently serving ICMR- National Animal Resource facility for Biomedical Research (NARFBR), Hyderabad. as a Scientist. Presently he is associated with preclinical vaccine testing Laboratory  at NARFBR. His area of working includes preclinical vaccinology studies, Host viral interactions studies of emerging human viral infections and Prevention and control of diseases and development of tools to prevent out breaks. He has done his Ph. D from ICMR-National Institute of Virology-Pune on human hepatitis B virus. He proved his credentials by working on HBV and HEV with his publication record. He has presented his work in numerous national and international conferences. He has proved his accolades with several publications in International Journals like Journal of General Virology, Journal of Virology, Journal of Travel Medicine, Indian Journal of Medical Microbiology, and Science of Total Environment. He is a well experienced manuscript writer and has contributed to several book chapters for publication bodies like Springer Nature, CRC-Press, Intech open, IGI Global Publications etc, Dr. Prudhvi also edited a book in springer Nature entitled “Emerging Human Viral Disease” in two volumes. His contribution for these books as an Editor will act as catalyst as his comments are really critical and an achievement for the book.

     

    Dr. Neelam Thakur is currently working as Assistant Professor in the Department of Zoology, Sardar Patel University (A State Govt. University), Mandi, Himachal Pradesh, since 2022. Before joining this university, she has worked as Associate Professor in the Department of Biosciences at Chandigarh University, Punjab, India. She obtained her Ph.D. in Genetics from Himachal Pradesh University in 2012. After her Ph.D., she has joined as Research Associate in Immunology lab of CSIR- Imtech, Chandigarh in 2012. Her research interests are early diagnosis of tuberculosis & cancer, nanotechnology for cancer diagnostics & therapy, cytogenetic analysis of intellectually disabled individuals and microbiome studies. She has supervised many master’s students and currently guiding Ph.D. students as well. She has published 18 research papers in journals with good impact factor like “Cellular Signaling”. Her patent entitled “ANTIGENIC COMPOSITION AND METHOD OF EXPRESSION THEREOF” is also published. She has received 2 Young Researchers Awards and 1 Eminent Researchers Award from govt. registered societies/ organizations for her contribution in research.