Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative Engineering: The Scaffold, provides a thorough update to the existing material, bringing together these two unique areas to give a perspective of the emerging therapeutic strategies for a wide audience.
New coverage includes:
- Updated discussion of the importance of scaffolds in tissue engineering
- Exploration of cellular interactions at the nanoscale
- Complete range of fabrication processes capable of developing nanostructured scaffolds for regenerative engineering
- Applications of nanostructured scaffolds for neural, skin, cardiovascular, and musculoskeletal regenerative engineering
- FDA approval process of nanostructure scaffolds
- Products based on nanostructured scaffolds
Due to the unique and tissue-mimic properties of the nanostructured scaffolds, the past five years have seen a tremendous growth in nanostructured materials for biological applications. The revised work presents the current state-of-the-art developments in nanostructured scaffolds for regenerative engineering.
Table of Contents
Importance of Scaffolds in Tissue Regeneration
Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century, Fan Yang, William L. Neeley, Michael J. Moore, Jeffrey M. Karp, Anita Shukla, and Robert Langer
From Microenvironment to Nanoenvironment: Ultrastructure and Function of Extracellular Matrix, Mandana Veiseh, Arya Nikjoo, Eva A. Turley, and Mina J. Bissell
Functions and Requirements of Synthetic Scaffolds in Tissue Engineering, Tejas Shyam Karande, J. Jordan M. Kaufmann, and C. Mauli Agrawal
Microfabrication Techniques in Scaffold Development, Christopher J. Bettinger, Jeffrey T. Borenstein, and Robert Langer
Effect of Nanostructures on Cellular Responses and Tissue Regeneration
Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective, Batur Ercan and Thomas Webster
Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications, Duron A. Lee, Keshia Ashe, and Cato T. Laurencin
Promising Nanofabrication Techniques for Scaffolds to Support Tissue Regeneration
Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration, Syam P. Nukavarapu, Sangamesh G. Kumbar, Jonathan G. Merrell, and Cato T. Laurencin
Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites, Eunice Phay Shing Tan, Mui Hoon Nai, and Chwee Teck Lim
Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization, Joel K. Wise, Eyal Zussman, Alexander L. Yarin, Constantine M. Megaridis, and Michael Cho
Nanolithographic Techniques in Tissue Engineering, Benjamin Moody and Gregory S. McCarty
Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine, Akihiro Horii, Xiumei Wang, and Shuguang Zhang
Applications of Nanostructured Scaffolds in Biology and Medicine
Nanotechnologies to Promote Skin Tissue Regeneration, Shalini V. Gohil, Eric James, and Lakshmi S. Nair
Nanotechnology for Neural Tissue Engineering, Tarun Saxena, S. Balakrishna Pai, Vivek Mukhatyar, and Ravi Bellamkonda
Nanotechnologies for Cardiovascular Tissue Engineering, Kristen A. Wieghaus, Cheryl M. Lau, and Edward A. Botchwey
Nanostructures for Musculoskeletal Tissue Engineering, Susan Liao, Casey K. Chan, and Seeram Ramakrishna
Regulatory Perspectives on Nanostructured Materials
Regulatory Process of Nanostructured Tissue-Engineered Scaffolds, Yusuf M. Khan
"This book very nicely assembles the key considerations in the use of nanotechnology in tissue engineering, including topics of nanofabrication techniques, interactions of cells with nano-structured materials, applications of nanostructured scaffolds, and the regulatory FDA issues in the use of nanomaterials. …All topics are well–suited to the overall direction of the book."
—Heungsoo Shin, Hanyang University, Korea
"The strengths of this book are that it brings together the fields of bionanotechnology and tissue engineering to develop a single concise text which explains the state of the art in the field of regenerative medicine. For a non-expert or undergraduate it starts by providing information on the fundamentals of tissue engineering but quickly moves into more informative chapters focused on cellular responses toward nanostructured materials and emerging nanofabrication techniques and how they can be applied towards developing biomimetic scaffolds for tissue regeneration. Specific clinical areas are focused upon in detail making the text valuable to researchers working in these areas. Uniquely in comparison to many to many textbooks, there is a chapter on regulatory perspectives on nanostructured materials thus proving information on the route to the market and of course the barriers that exist therein. This is an excellent addition and provides valuable information at all levels- from explaining basic regulatory challenges to undergraduates to informing professors on the route to the market for technologies developed in their labs."
—Professor Fergal O’Brien, Chair of Bioengineering & Regenerative Medicine, Royal College of Surgeons in Ireland & Trinity College Dublin
"Langer in his inimitable style has given us an extraordinary overview of where we stand in the field of tissue engineering. …This book provides an excellent combination of the principles of biomaterials, bioengineering and biology. This is very hard to find and I highly recommend it."
—Shanti Nair, Amrita University, India
"It covers several important topics that are important to someone entering or working in the field."
—Guillermo Ameer, Northwestern University, Evanston, Illinois, USA