Nanotoxicology: Progress toward Nanomedicine, Second Edition, 2nd Edition (Paperback) book cover


Progress toward Nanomedicine, Second Edition, 2nd Edition

Edited by Nancy A. Monteiro-Riviere, C. Lang Tran

CRC Press

514 pages | 106 B/W Illus.

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Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts todocument the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.

Topics include

  • The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
  • The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications
  • Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
  • Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
  • Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
  • Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications
  • The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
  • A roadmap for future research

The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Table of Contents

Impacts of Nanotechnology on Biomedicine

Introduction to Biomedical Nanotechnology; Dorothy Farrell, George Hinkal, and Piotr Grodzinski

Impact of Bionanointeractions of Engineered Nanoparticles for

Nanomedicine; Stefania Sabella

Rational Approach for the Safe Design of Nanomaterials; Anna L. Costa

Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing; Keld A. Jensen, Giulio Pojana, and Dagmar Bilaničová


Workplace Inhalation Exposure to Engineered Nanomaterials:

Detection, Measurement, and Assessment; Araceli Sánchez Jiménez, Derk Brouwer, and Martie Van Tongeren

Nanotechnology in Consumer Products: Addressing Potential

Health and Safety Implications for Consumers; Treye A. Thomas


Quantitative Nanostructure–Activity Relationships: From

Unstructured Data to Predictive Models for Designing

Nanomaterials with Controlled Properties; Denis Fourches and Alexander Tropsha

Pharmacokinetics and Biodistribution of Nanomaterials; Jim E. Riviere

Methodologies and Techniques

Advanced Methodologies and Techniques for Assessing

Nanomaterial Toxicity: From Manufacturing to Nanomedicine

Screening; Adriele Prina-Mello, Bashir M. Mohamed, Navin K. Verma, Namrata Jain, and Yuri Volkov

Detection Methods for the In Vivo Biodistribution of Iron

Oxide and Silica Nanoparticles: Effects of Size, Surface

Chemistry, and Shape; Heather A. Enright and Michael A. Malfatti

Quantitative Single-Cell Approaches to Assessing Nanotoxicity in

Nanomedicine Systems; James F. Leary

Imaging Techniques for Nanoparticles in Skin; Tarl W. Prow


Safety Implications of Nanomaterial Exposure to Skin; Nancy A. Monteiro-Riviere

Interspecies Comparisons of Pulmonary Responses to

Fine and/or Nanoscale Particulates: Relevance for Humans of

Particle-Overload Responses in the Rat Model; David B. Warheit and Kenneth L. Reed

Current In Vitro Models for Nanomaterial Testing in

Pulmonary Systems; Sonja Boland, Sandra Vranic, Roel Schins, and Tobias Stöger

Nanoparticles and the Immune System; Bengt Fadeel and Diana Boraschi

Carbon Nanotubes and Cardiovascular Disease; Peter Møller, Cao Yi, Lise K. Vesterdal, Pernille H. Danielsen, Martin Roursgaard, Henrik Klingberg, Daniel V. Christophersen, and Steffen Loft

Single- and Multi-walled Carbon Nanotubes Toxicity and

Potential Applications in Neuroregeneration; Fariborz Tavangarian, Guoqiang Li, and Yiyao Li

Current In Vitro Models for Nanomaterial Testing: The

Reproductive System; Gary R. Hutchison and Bryony L. Ross

Current In Vitro Models for Nanomaterial Testing: Genotoxicity

Issues; Laetitia Gonzalez, Sara Corradi, and Micheline Kirsch-Volders

Cell-Based Targeting of Anticancer Nanomaterials to Tumors; Matt Basel, Tej Shrestha, Hongwang Wang, and Stefan Bossmann

Silver Nanoparticles in Biomedical Applications; Meghan E. Samberg and Nancy A. Monteiro-Riviere

Cytotoxicity of Conjugated and Unconjugated Semiconductor and

Metal Nanoparticles; Jay Nadeau

Risk Assessment

Issues Related to Risk Assessment of Nanomaterials; Maureen R. Gwinn

Risk Assessment of Engineered Nanomaterials: State of the

Art and Roadmap for Future Research; Danail Hristozov, Laura MacCalman, Keld A. Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes, and Antonio Marcomini


About the Editors

Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.

C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Toxicology