Nanotoxicology : Progress toward Nanomedicine, Second Edition book cover
2nd Edition

Progress toward Nanomedicine, Second Edition

ISBN 9781138033993
Published November 16, 2016 by CRC Press
514 Pages 106 B/W Illustrations

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Book Description

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.

Topics include

  • The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
  • The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications
  • Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
  • Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
  • Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
  • Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications
  • The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
  • A roadmap for future research

The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Table of Contents

Impacts of Nanotechnology on Biomedicine
Introduction to Biomedical Nanotechnology; Dorothy Farrell, George Hinkal, and Piotr Grodzinski
Impact of Bionanointeractions of Engineered Nanoparticles for
Nanomedicine; Stefania Sabella
Rational Approach for the Safe Design of Nanomaterials; Anna L. Costa
Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing; Keld A. Jensen, Giulio Pojana, and Dagmar Bilaničová
Workplace Inhalation Exposure to Engineered Nanomaterials:
Detection, Measurement, and Assessment; Araceli Sánchez Jiménez, Derk Brouwer, and Martie Van Tongeren
Nanotechnology in Consumer Products: Addressing Potential
Health and Safety Implications for Consumers; Treye A. Thomas
Quantitative Nanostructure–Activity Relationships: From
Unstructured Data to Predictive Models for Designing
Nanomaterials with Controlled Properties; Denis Fourches and Alexander Tropsha
Pharmacokinetics and Biodistribution of Nanomaterials; Jim E. Riviere
Methodologies and Techniques
Advanced Methodologies and Techniques for Assessing
Nanomaterial Toxicity: From Manufacturing to Nanomedicine
Screening; Adriele Prina-Mello, Bashir M. Mohamed, Navin K. Verma, Namrata Jain, and Yuri Volkov
Detection Methods for the In Vivo Biodistribution of Iron
Oxide and Silica Nanoparticles: Effects of Size, Surface
Chemistry, and Shape; Heather A. Enright and Michael A. Malfatti
Quantitative Single-Cell Approaches to Assessing Nanotoxicity in
Nanomedicine Systems; James F. Leary
Imaging Techniques for Nanoparticles in Skin; Tarl W. Prow
Safety Implications of Nanomaterial Exposure to Skin; Nancy A. Monteiro-Riviere
Interspecies Comparisons of Pulmonary Responses to
Fine and/or Nanoscale Particulates: Relevance for Humans of
Particle-Overload Responses in the Rat Model; David B. Warheit and Kenneth L. Reed
Current In Vitro Models for Nanomaterial Testing in
Pulmonary Systems; Sonja Boland, Sandra Vranic, Roel Schins, and Tobias Stöger
Nanoparticles and the Immune System; Bengt Fadeel and Diana Boraschi
Carbon Nanotubes and Cardiovascular Disease; Peter Møller, Cao Yi, Lise K. Vesterdal, Pernille H. Danielsen, Martin Roursgaard, Henrik Klingberg, Daniel V. Christophersen, and Steffen Loft
Single- and Multi-walled Carbon Nanotubes Toxicity and
Potential Applications in Neuroregeneration; Fariborz Tavangarian, Guoqiang Li, and Yiyao Li
Current In Vitro Models for Nanomaterial Testing: The
Reproductive System; Gary R. Hutchison and Bryony L. Ross
Current In Vitro Models for Nanomaterial Testing: Genotoxicity
Issues; Laetitia Gonzalez, Sara Corradi, and Micheline Kirsch-Volders
Cell-Based Targeting of Anticancer Nanomaterials to Tumors; Matt Basel, Tej Shrestha, Hongwang Wang, and Stefan Bossmann
Silver Nanoparticles in Biomedical Applications; Meghan E. Samberg and Nancy A. Monteiro-Riviere
Cytotoxicity of Conjugated and Unconjugated Semiconductor and
Metal Nanoparticles; Jay Nadeau
Risk Assessment
Issues Related to Risk Assessment of Nanomaterials; Maureen R. Gwinn
Risk Assessment of Engineered Nanomaterials: State of the
Art and Roadmap for Future Research; Danail Hristozov, Laura MacCalman, Keld A. Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes, and Antonio Marcomini

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Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.

C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.