2nd Edition

Nanotoxicology Progress toward Nanomedicine, Second Edition

Edited By Nancy A. Monteiro-Riviere, C. Lang Tran Copyright 2014
    514 Pages 106 B/W Illustrations
    by CRC Press

    514 Pages 106 B/W Illustrations
    by CRC Press

    Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.

    Topics include

    • The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
    • The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications
    • Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
    • Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
    • Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
    • Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications
    • The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
    • A roadmap for future research

    The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

    Impacts of Nanotechnology on Biomedicine
    Introduction to Biomedical Nanotechnology; Dorothy Farrell, George Hinkal, and Piotr Grodzinski
    Impact of Bionanointeractions of Engineered Nanoparticles for
    Nanomedicine; Stefania Sabella
    Rational Approach for the Safe Design of Nanomaterials; Anna L. Costa
    Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing; Keld A. Jensen, Giulio Pojana, and Dagmar Bilaničová
    Workplace Inhalation Exposure to Engineered Nanomaterials:
    Detection, Measurement, and Assessment; Araceli Sánchez Jiménez, Derk Brouwer, and Martie Van Tongeren
    Nanotechnology in Consumer Products: Addressing Potential
    Health and Safety Implications for Consumers; Treye A. Thomas
    Quantitative Nanostructure–Activity Relationships: From
    Unstructured Data to Predictive Models for Designing
    Nanomaterials with Controlled Properties; Denis Fourches and Alexander Tropsha
    Pharmacokinetics and Biodistribution of Nanomaterials; Jim E. Riviere
    Methodologies and Techniques
    Advanced Methodologies and Techniques for Assessing
    Nanomaterial Toxicity: From Manufacturing to Nanomedicine
    Screening; Adriele Prina-Mello, Bashir M. Mohamed, Navin K. Verma, Namrata Jain, and Yuri Volkov
    Detection Methods for the In Vivo Biodistribution of Iron
    Oxide and Silica Nanoparticles: Effects of Size, Surface
    Chemistry, and Shape; Heather A. Enright and Michael A. Malfatti
    Quantitative Single-Cell Approaches to Assessing Nanotoxicity in
    Nanomedicine Systems; James F. Leary
    Imaging Techniques for Nanoparticles in Skin; Tarl W. Prow
    Safety Implications of Nanomaterial Exposure to Skin; Nancy A. Monteiro-Riviere
    Interspecies Comparisons of Pulmonary Responses to
    Fine and/or Nanoscale Particulates: Relevance for Humans of
    Particle-Overload Responses in the Rat Model; David B. Warheit and Kenneth L. Reed
    Current In Vitro Models for Nanomaterial Testing in
    Pulmonary Systems; Sonja Boland, Sandra Vranic, Roel Schins, and Tobias Stöger
    Nanoparticles and the Immune System; Bengt Fadeel and Diana Boraschi
    Carbon Nanotubes and Cardiovascular Disease; Peter Møller, Cao Yi, Lise K. Vesterdal, Pernille H. Danielsen, Martin Roursgaard, Henrik Klingberg, Daniel V. Christophersen, and Steffen Loft
    Single- and Multi-walled Carbon Nanotubes Toxicity and
    Potential Applications in Neuroregeneration; Fariborz Tavangarian, Guoqiang Li, and Yiyao Li
    Current In Vitro Models for Nanomaterial Testing: The
    Reproductive System; Gary R. Hutchison and Bryony L. Ross
    Current In Vitro Models for Nanomaterial Testing: Genotoxicity
    Issues; Laetitia Gonzalez, Sara Corradi, and Micheline Kirsch-Volders
    Cell-Based Targeting of Anticancer Nanomaterials to Tumors; Matt Basel, Tej Shrestha, Hongwang Wang, and Stefan Bossmann
    Silver Nanoparticles in Biomedical Applications; Meghan E. Samberg and Nancy A. Monteiro-Riviere
    Cytotoxicity of Conjugated and Unconjugated Semiconductor and
    Metal Nanoparticles; Jay Nadeau
    Risk Assessment
    Issues Related to Risk Assessment of Nanomaterials; Maureen R. Gwinn
    Risk Assessment of Engineered Nanomaterials: State of the
    Art and Roadmap for Future Research; Danail Hristozov, Laura MacCalman, Keld A. Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes, and Antonio Marcomini


    Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.

    C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.