Compiled by an international group of more than 40 authors, this reference book supplies an engaging and comprehensive review of the major topics and key issues associated with narcolepsy and hypersomnia. Spanning the latest advances in the field, this source covers current diagnostic procedures, genetic developments, explorations of animal models, new definitions and criteria, and improved epidemiological surveys to reflect the explosion of research in this evolving science.
Table of Contents
Historical Aspects. English Translations of the First Clinical Reports. Historical Aspects of Treatment. Narcolepsy and Hypersomnia: Immunogenetic Aspects. The Hypocretins. Cataplexy. Effect of Age on Narcolepsy. Narcolepsy in Children and Adolescents. Idiopathis Hypersomnia. Kleine-Levin Syndrome and Other Recurrent Hypersomnias. Spectrum of Narcolepsy. Sleep Paralysis, State Transition Disruptions, and Narcolepsy. Epidemiology: Development of the Ullanlinna Narcolepsy Scale. Epidemiology II. Alternate Etiologies. Neurophysiology. Abnormal Motor Activity During Sleep. Circadian and Ultradian Aspects. Homeostatic Sleep Regulation. Daytime Variations in Alertness/Drowsiness. Molecular Characterization of Hypocretin/Orexin and Melanin Concentrating Hormone Neurons. Nocturnal Polysomnography. Canine Narcolepsy. Vigilance Tests. Lessons from Sleepy Mice. Hypocretin-1 studies: the European Experience. Hypocretin-1/Orexin-A: the US Experience. Hypocretin Pathology. Symptomatic Narcolepsy with Cataplexy. Poststroke and Posttraumatic Hypersomnia. Potential Mechanisms of the Wake-Promoting Action of Hypocretin/Orexin. Normal Role of Hypocretin/Orexin. Role of Hypocretin/Orexin in the Neurobiology of Sleep and Alertness. Hypocretin, GABA-B Receptors, and Sleep. Activity Profile of Hypocretin Neurons in the Freely Moving Rat. Input and Output of Orexin/Hypocretin Neurons. Human Leukocyte Antigen and Narcolepsy. Non-HLA Genes. Mutation Screening of the Hypocretin System Genes. Environmental Factors. Autoimmune Studies. Metabolic Abnormalities. Hormomal Abnormalities. Psychosocial Impact. Driving. Comorbidity. Behavioral Management. Pharmacology of CNS Stimulants. Anticataplectic Medications. Modafinil: Mechanisms of Action. Modafinil: the European Experience. Modafinil: the US Experience. Molecular and Cellular Actions of Gamma-Hydroxybutyric Acid. Sodium Oxybate. Perspectives for New Treatments. Diagnostic Criteria for Syndromes of Excessive Daytime Sleepiness. Appendixes: Guidelines for the Appropriate Use of CSF Measurements to Diagnose Narcolepsy. Treatment Guidelines.