A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies.
The book begins by introducing key issues and providing a historical overview of the field of memory consolidation. The following chapters review the putative genetic and molecular mechanisms of cell plasticity, elaborating on how experience could induce gene and protein expression and describing their role in synaptic plasticity underlying memory formation. They explore how putative modifications of brain circuits and synaptic elements through experience can become relatively permanent and hence improve brain function.
Interdisciplinary reviews focus on how nerve cell circuitry, molecular expression, neurotransmitter release, and electrical activity are modified during the acquisition and consolidation of long-term memory. The book also covers receptor activation/deactivation by different neurotransmitters that enable the intracellular activation of second messengers during memory formation. It concludes with a summary of current research on the modulation and regulation that different neurotransmitters and stress hormones have on formation and consolidation of memory.
Table of Contents
Searching for Memory in the Brain: Confronting the Collusion of Cells and Systems. Long-Term Potentiation and Depression as Putative Mechanisms for Memory Formation. Molecular Mechanisms of Synaptic Plasticity Underlying Long Term Memory Formation. Modification of Brain Circuits through Experience. Presynaptic Structural Plasticity and Long-Lasting Memory: Focus on the Learning-Induced Redistribution of Hippocampal Mossy Fibers. Electrophysiological Representation of Taste Memory. Changes in Neurotransmitters Extracellular Levels During Memory Formation. Reversible Brain Inactivation of Brain Circuits in Learning and Memory Research. Enhanced Learning Protects the Brain Against the Effects of Amnesic Treatments. Studies on Short-Term Avoidance Memory. Memory Reconsolidation or Post-Retrieval Updating Information? Memory Impairments by Stress and Aging. Adrenal Stress Hormones and Enhanced Memory for Emotionally Arousing Experiences. Neuro-Immune Associative Learning. Sex and Hemisphere Influences on Neural Mechanisms of Emotional Memory.