Neural and Metabolic Control of Macronutrient Intake: 1st Edition (Hardback) book cover

Neural and Metabolic Control of Macronutrient Intake

1st Edition

Edited by Hans-Rudolf Berthoud, Randy J. Seeley

CRC Press

528 pages

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Hardback: 9780849327520
pub: 1999-10-25
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When an excessive proportion of the human energy requirement is derived from fat, the likelihood of obesity increases. Any such individual is at risk for diabetes and cardiovascular disease- grave and costly health hazards. The selective control of fat ingestion is a promising solution to these concerns.

Existing data suggests that macronutrient intake can be manipulated. Further research is working to create pharmacological tools that will suppress fat consumption. It will also be possible to fight obesity, heart disease and diabetes.

Neural and Metabolic Control of Macronutrient Intake systematically discusses the known physiological mechanisms involved in macronutrientselection, including their molecular, genetic and neurochemical aspects. The book is also a critical review of the hypothesis that ingestion of the three nutrients is regulated by separate neural control mechanisms, leaving open the possibility that strategies could be devised to intervene in bodily control systems and alter the proportion of fat in the diet.

This reference provides three types of information: First, the basic background of the biochemical and physiological systems as they relate to macronutrient selection. Second, opinions and data concerning to what degree animals and humans show evidence of macronutrient selection. And, third, evidence about how the central nervous system might be involved in the choices animals make among macronutrients.


"What emerges from the Berthoud and Seeley volume is a remarkable consensus among many of the leading neuroscientists."

-Adam Drenowski, PhD, Department of Epidemiology and Medicine, University of Washington, Seattle, Washington, USA

"Few advanced texts in neuroscience offer such a strong endorsement of behavioral nutrition and dietetic practice."

-Adam Drenowski, PhD, Department of Epidemiology and Medicine, University of Washington, Seattle, Washington, USA

Table of Contents

Evidence for Macronutrient Selection: Basic Mechanisms and Strategies to Achieve Regulation

Specific Appetites and Homeostatic Systems-Edward M. Stricker

Too Many Choices? A Critical Essay on Macronutrient Selection-Mark I. Friedman

Is There a Specific Appetite for Protein?-Bennett G. Galef, Jr.

Geometric Models of Macronutrient Selection

-Stephen J. Simpson and David Raubenheimer

Macronutrient Selection in Free Feeding Humans: Evidence for Long Term Regulation-John M. de Castro

Macronutrient-Specific Hungers and Satieties and Their Neural Bases, Learnt From Pre-and Post-Ingestional Effects of Eating Particular Foodstuffs-David A. Booth and Louise Thibault

Macronutrient-Conditioned Flavor Preferences-Anthony Sclafani

Evidence for Caloric, but Not Macronutrient Compensation, to Preloads Varying in Fat and Carbohydrate Content in Human Subjects

-Barbara J. Rolls and Timothy H. Moran

The Effects of Nutrient Preloads on Subsequent Macronutrient Selection in Animal Models-

L. A. Foster

Effects of Metabolic Processing on Energy Intake and Macronutrient Selection

Intermediary Metabolism of Macronutrients-Malcom Watford

Physiological and Metabolic Control of Macronutrient Balance-J. P. Flatt

Carbohydrate and Fat Metabolism, Appetite and Feeding Behavior in Humans-R. James Stubbs and L. M. O'Reilly

Effects of Metabollic Blockade on Macronutrient Seclection-Sue Ritter, Frank H. Koegler, and Michael Wiater

Memory and Macronutrient Regulation

-Terry L. Davidson, Javier R. Morell, and Stephen C. Benoit

Effects of Food Deprivation, Starvation, and Exercise on Dietary Selction in the Rat-T. W. Castonguay and L. M. Brown

Effects of Fat Substitutes and Inhibitors of Absorption on Macronutrient Intake-Karen Ackroff

Detection of Macronutrients and Their Metabolites

Taste, Olfactory, Visual and Somatosensory Representations of the Sensory Properties of Foods in the Brain, and Their Relation to the Control of Food Intake-Edmund T. Rolls

Satiation in Response to Macronutrient Signals From the Intestine: Mechanisms and Implications for Macronutrient Selction-Mihai Covasa and Robert C. Ritter

Fat Absorption and the Role of Lymphatic Apolipoprotein A-IV in the Regulation of Food Intake-P. Tso and K. Fukagawa

Enterostatin as a Regulator of Fat Intake-David A. York, Ling Lin , Brenda K. Smith, and Jian Chen

Portal-Hepatic Sensors for Glucose, Amino Acids, Fatty Acids, and Availability of Oxidative Products-Wolfgang Langhans

Glucosensing Neurons in the Central Nervous System-Barry E. Levin, Vanessa H. Routh, and Ambrose A. Dunn-Meynell

Amino Acid Recognition in the Central Nervous System-Dorothy W. Gietzen

Neural Integration of Sensory and Metabolic Information in the Control of Macronutrient Selection

An Overview of Neural Pathways and Networks Involved in the Control of Food Intake and Selection-Hans-Rudolf Berthoud

Macronutrients and Brain Peptides: What they Do and How They Respond-Sarah F. Leibowitz

Opioids, Food Reward, and Macronutrient Selection-Michael J. Glass, Chales J. Billington, and Allen S. Levine

Serotonin (5-HT) and Serotoninergic Receptors in the Regulation of Macronutrient Intake-J.C. G. Halford, B. K. Smith, and J. E. Blundell

Effects of Pure Macronutrient Diets on 5-HT Release in the Rat Hypothalamus: Relationship to Insulin Secretion and Possible Mechanism for Feedback Control of Fat and Carbohydrate Ingestion

-M. Orosco, K. Gerozissis, and S. Nicolaïdis

Quatitative and Macronutrient-Related Regulation of Hypothalamic Neuropeptide Y, Galanin and Neurotensin-Bernard Beck

Adiposity Signals and Macronutrient Selection-Gertjan van Dijik, Mark Chavez, Christine A. Riedy, and Stephen C. Woods

Stress and Macrontnutrient Selection-Ruth B. S. Harris, Leigh Anne Howell, Tiffany D. Mitchell, Bradley D. Youngblood, David A. York, and Donna H. Ryan


Neural and Metabolic Control of Macronutrient Selection: Consensus and Controversy-Randy J. Seeley, and Hans-Rudolf Berthoud

About the Authors/Editors

Hans-Rudolf Berthoud, Randy J. Seeley

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Nutrition
SCIENCE / Life Sciences / General
SCIENCE / Life Sciences / Neuroscience