Neurobiology of DOPA as a Neurotransmitter

HISTORY
L-DOPA: A Historical Perspective, O. Hornykiewicz

BIOSYNTHESIS, METABOLISM, ACTIVE TRANSPORT, AND EXISTENCE
DOPA as a Neurotransmitter Candidate, Y. Misu and Y. Goshima
Active Uptake System of L-DOPA in CNS, Y. Sasaki, Y. Goshima, and Y. Misu
Morphology of DOPAergic Neurons in Mammals, H. Okamura, T. Ueyama, S. Masubuchi, and K. Kitahama

RELEASE
Physiological Release of DOPA, Y. Misu, K. Honjo, and Y. Goshima
Mechanisms of Calcium-Associated Exocytosis of Striatal Dopamine and DOPA Release Studied by In Vivo Microdialysis, M. Okada, G. Zhu, S. Yoshida, S. Hirose, and S. Kaneko
Release of DOPA from Dog Peripheral Tissues, G.M. Tyce, L.W. Hunter, E.W. Kristensen, S.L. Chritton, and D.K. Rorie

PHARMACOLOGY
Presynaptic Responses to Levodopa, Suggesting the Existence of DOPA Recognition Sites, Y. Goshima and Y. Misu
The Neuroregulatory Properties of Levodopa: Evidence and Potential Role in the Treatment of Parkinson's Disease, J. Tedroff
General Survey of Blood Pressure Regulation in Lower Brainstem and Responses to Levodopa and Glutamate, T. Kubo
Physiological and Pharmacological Responses to DOPA Involved in Baroreflex Neurotransmission in the Lower Brainstem of Anesthetized Rats, Y. Misu, K. Honjo, and Y. Goshima
Glutamatergic and Nitroxidergic Neurotransmission in the Nucleus Tractus Solitarii, W.T. Talman and L.-H. Lin
Is DOPA a Reliable Neurotransmitter of Baroreflex Neurotransmission in the Brainstem? M.-K. Sun
Levodopa Causes Increased Activity in Rats: The Clinical Implications, T. Nakazato
Behavioral Effects of Exogenously Applied and Endogenously Released DOPA, Y. Misu, K. Honjo, and Y. Goshima
Modulatory Effects of Levodopa on D2 Dopamine Receptors in Striatum Assessed Using In Vivo Microdialysis and PET, J. Opacka-Juffry and S.P. Hume
Dopamine-Independent Inhibition of Hippocampal CA1 Neurons Produced by Nanomolar Levodopa with Facilitation of Noradrenaline and GABA Release in Rats, M. Sasa, K. Ishihara, M. Akbar, and Y. Misu

NEUROTOXICOLOGY
Levodopa-Induced Vesicular Release of Glutamate and Mechanisms of Levodopa-Induced Neurotoxicity in Primary Neuron Cultures in Rat Striata, A. Akaike and T. Maeda
Neuroprotective and Neurotoxic Effects of L-DOPA in Rat Midbrain Dopaminergic Neurons in Culture, M. Angeles Mena, M.J. Casarejos, E. Rodríguez-Martín, R.M. Solano, J. Menéndez, and J. García de Yébenes
DOPA-an Upstream Factor for Glutamate Release and Delayed Neuron Death by Transient Ischemia in Striatum and Hippocampal CA1 Region of Conscious Rats, Y. Misu and Y. Goshima
Effect of Neonatal Treatment with Monosodium Glutamate on Dopamine and DOPA Neurons in the Medial Basal Hypothalamus of Rats, I. Bodnár, D. Szekács, M. Oláh, H. Okamura, M. Vecsernyés, M.I.K. Fekete, and G.M. Nagy
Molecular Mechanism of Memantine in Treatment of Alzheimer's Disease and Other Neurologic Insults, S.A. Lipton
Index

Biography

Yoshimi Misu, Yoshio Goshima

"…a highly detailed review of antipsychotic drugs and neuroreceptors. There are many reviews of psychopharmacology, but this is one of the most specialized and exhaustive I have read. Any clinician or researcher interested in antipsychotic medications would find it a useful addition to their library."
-William Miles, M.D., Rush-Presbyterian-St. Luke's Medical Center
"The editors have succeeded well in their objective: to begin bridge the gap between the lab and the clinic. Dopamine, dopamine receptors, and dopamine transport lie at the core of important human disorders such as schizophrenia and Parkinson's disease. 4 Stars!"
- Daniel B. Hier, MD, University of Illinois at Chicago College of Medicine, for Doody's Review

"… present a timely overview of the different aspects of this amino acid in neurotransmission. … written by over 40 leading experts … a must-read for every neuroscientist working on endogenous neurotransmitters."

– Karl Gademann, Switzerland in ChemMedChem, 1, 2006