Based on a foundation of science and empirical observation, engineering research and design has brought science fiction into science fact. The convergence of neuroscience and technology is facilitating the development of therapies that not long ago would have seemed unimaginable, if not impossible. With contributions from pioneers in industry, academia, and clinical medicine, Neuroengineering provides an understanding of the history, physiology and the most promising engineering technologies.
The book presents clinical applications of neuromodulation and a detailed review of the science and mechanisms of action underlying deep brain stimulation. Contributions include discussions of seizure control, clinical, surgical, and technological aspects of responsive neurostimulation, and a thorough review of spinal cord stimulation for pain control. The book highlights promising technologies and applications for neural augmentation, brain and computer interfaces, and motor protheses. It concludes with coverage of the science underlying current neurostimulation techniques and new paradigm-shifting neuromodulation technologies.
We are on the cusp of a technological revolution that promises to have more of an impact on human health, disease, and quality of life than any other in recent history. Its impact on medicine and society promises to be as dramatic as that of the development of antibiotics. The transition of neural engineering from basic research to intense commercialization and widespread clinical application and acceptance is just around the corner. Providing in-depth coverage of cutting-edge developments in technology and clinical practice, the book presents detailed descriptions of technologies, science, and clinical results that build a foundation for the future.
Table of Contents
History and Overview of Neural Engineering. Cellular Mechanisms of Action of Therapeutic Brain Stimulation. Interfering with the Genesis and Propagation of Epileptic Seizures by Neuromodulation. Responsive Neurostimulation for Epilepsy — Neurosurgical Experience: Patient Selection and Implantation Technique. Responsive Neurostimulation for Epilepsy: RNS™ Technology and Clinical Studies. Deep Brain Stimulation for Pain Management. Spinal Cord Stimulation for Pain Management. Motor Cortex Stimulation for Pain Management. Deep Brain Stimulation for Obsessive Compulsive. Cochlear Prostheses. Visual Prostheses. General Clinical Issues Relevant to Brain-Computer Interfaces. Implantable Brain-Computer Interfaces: Neurosurgical Experience and Perspective. Comparing Electrodes for Use as Cortical Control Signals. Neuromotor Prosthetics: Design and Future Directions. Transcutaneous FES for Ambulation. Development of a Multi-functional 22-Channel Functional Electrical Stimulator for Paraplegia. An Implantable Bionic Network of Injectable Neural Prosthetic Devices. Tapping into the Spinal Cord for Restoring Function after Spinal Cord Injury. Theory and Physiology of Electrical Stimulation of the Central Nervous. Transient Optical Nerve Stimulation. Transcranial Magnetic Stimulation of Deep Brain Regions. Application of Neural Plasticity for Vision Restoration after Brain Damage.
Daniel J. DiLorenzo, Joseph D. Bronzino