Neurological Complications of Systemic Cancer and Antineoplastic Therapy  book cover
1st Edition

Neurological Complications of Systemic Cancer and Antineoplastic Therapy

ISBN 9780849391910
Published July 21, 2010 by CRC Press
648 Pages 100 B/W Illustrations

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Book Description

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.

Highlights include:

  • The pathophysiology and molecular biology of cancer and the metastatic phenotype
  • Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses
  • Metabolic and nutritional disorders
  • CNS infections
  • Neurological complications of immunotherapy and bone marrow transplants

Additional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy.

Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

Table of Contents

Biology and pathophysiology of nervous system metastases

Herbert B Newton and Mark G Malkin

Intracranial metastases

Herbert B Newton and Mark G Malkin

Epidural metastasis and spinal cord compression

Nader Pouratian, Mark E Shaffrey, and David Schiff

Leptomeningeal metastasis

Linda D Grossheim and Mark G Malkin

Cranial nerve involvement by metastatic cancer

Paul L Moots

Cancer-related plexopathies

Paul L Moots and Michael Edgeworth

Cerebrovascular complications of malignancy

Joseph Rudolph and Jeffrey M Katz

Metabolic and nutritional nervous system dysfunction in cancer patients

Herbert B Newton

Central nervous system infections in cancer patients

Amy A Pruitt

Diagnosis and treatment of paraneoplastic neurological disorders

Annick Desjardins

Neurological complications of lung cancer

Linda D Grossheim, Mark G Malkin, Suriya A Jayapalan, and John W Henson

Neurological complications of breast cancer

Neil E Anderson

Neurological complications of malignant melanoma

Maciej M Mrugala and John W Henson

Neurological complications of leukemia and lymphoma

Lynne P Taylor

Neurological complications of head and neck cancer

Marta Penas-Prado and Morris D Groves

Neurological complications of gynecological cancers

Susan C Pannullo, Eliana T Muskin, Robert D Zimmerman, and Jennifer A Moliterno

Neurological complications of GI cancers

Larry Junck and Mark M Zalupski

Neurologic complications associated with genitourinary cancer

Samer S Kasbari, Marc S Ernstoff, and Camilo E Fadul

CNS complications of sarcoma

Ed Olson and Jeffrey J Raizer

Neurological complications of multiple myeloma

Nina A Paleologos and Allison L Weathers

Neurologic complications of cancer and its therapy during childhood

Mark T Jennings

Neurological complications of radiotherapy

Jeremy Rudnick and Lauren E Abrey

Neurological complications of chemotherapy

April F Eichler and Patrick Y Wen

Neurological complications of immunotherapy

Florence Laigle-Donadey, Gentian Kaloshi, and Jean-Yves Delattre

Neurological complications of steroids and of supportive care

Willem-Johan van de Beek and Charles J Vecht

Psychiatric aspects of care in the cancer patient

William S Breitbart and Yesne Alici

Chronic cancer pain syndromes and their treatment

Nathan I Cherny

Psychosocial issues

Jane R Schubart, Elana Farace, and Robert Cavaliere

Supportive care

Herbert B Newton and Mark G Malkin


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Herbert B. Newton, M.D., is Professor of Neurology, Co-Director, Dardinger Neuro-Oncology Center , Esther Dardinger Endowed Chair in Neuro-Oncology and Director in the Division of Neuro-Oncology at the Ohio State University Medical Center, Columbus, Ohio. Dr. Newton is also an Attending Physician in Neuro-Oncology at The Arthur G. James Cancer Hospital and Solove Research Institute and Staff Physician in the Section of Neurology at the Children's Hospital of Columbus. He is a diplomate of the American Board of Psychiatry and Neurology, a Fellow of the American Academy of Neurology and Royal Society of Medicine, and a member of numerous national and international societies.

Mark G. Malkin M.D., is Chief of the Division of Neuro-oncology in the Department of Neurology, and Professor of Neurology and Neurosurgery at the Medical College of Wisconsin, Milwaukee, Wisconsin. Dr. Malkin is also on the active staff of Froedtert Memorial Lutheran Hospital, where he serves as Co-Chair of the Cancer Committee. He is a Fellow of both the Royal College of Physicians of Canada (Neurology) and the American Academy of Neurology. In 2005 he received the Excellence in Clinical Teaching Award from the Department of Neurology at the Medical College of Wisconsin.