1st Edition

Neuromuscular Pathology Made Easy

Edited By

Maher Kurdi

  • Available for pre-order. Item will ship after January 10, 2021
ISBN 9780367557263
January 10, 2021 Forthcoming by CRC Press
240 Pages

USD $74.95

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Book Description

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy.

This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables.

  • A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases

  • Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis
  • Practical tips to facilitate histopathological diagnosis.
  • Clinical scenarios discussing common neuromuscular conditions

Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

Table of Contents

Section A General

Chapter 1: Muscle and Nerve Histology

1.1. Muscle histology

1.1.a Mitochondria

1.2. Peripheral nerve histology

Chapter 2: Muscle and Nerve Fibers Classification

2.1. Muscle fiber classification

2.2. Peripheral nerve classification

Chapter 3: Clinical Neurophysiology with Ahmed Abuzinadah

3.1. Nerve conduction study

3.2. Electromyography

Chapter 4: Neuromuscular Laboratory

Chapter 5: Chemical Materials Used in the Lab

Chapter 6: Biopsy Processing Protocol with Habib Bin Attiah

6.1. Muscle

6.2. Nerve

Chapter 7: Histochemistry Protocol with Fawaz Siddiq

7.1. Histochemical reaction

7.2. Histochemical methods

7.3. Immunohistochemistry

7.4. Histological artifacts

Chapter 8: Genetic Basis with Ashraf Dallol

8.1. Single or multiple gene approach

8.2. Whole exam and genome sequencing

8.3. RNA sequencing

Chapter 9: Neuromuscular Final Report

9.1. Muscle biopsy report template

9.2. Nerve biopsy report template

Section B Muscle

Chapter 10: Initial Approach in Muscle Biopsy

10.1. Myopathic features

10.2. Neuropathic features

10.3. Dystrophic features

Chapter 11: Differential Diagnosis

Chapter 12: Electron Microscopy

Chapter 13: Classification of Myopathy

Chapter 14: Approach to Neuromyopathy

14.1. Neuromyopathy with lack of inflammation

14.1.a. Paraneoplastic-induced neuromyopathy

14.1.b. Drug-induced neuromyopathy

14.2. Neuromyopathy with inflammation

Chapter 15: Approach to Vacuolar Myopathy

Chapter 16: Muscular Dystrophy Diseases

Chapter 17: Inherited Myopathic Diseases

Chapter 18: Non-Congenital Acquired Myopathies

18.1. Chronic diseases-induced myopathies

18.2. Toxic myopathies

18.2.a. Statin-induced myopathy

18.3. Critical care illness myopathy

Chapter 19: Metabolic Myopathies

19.1. Glycogen storage diseases

19.1.a. POMPE disease

19.2. Lipid storage diseases

19.3. Mitochondrial myopathies

19.4. Other metabolic myopathies

19.4.a. Amyloid myopathy

Chapter 20: Inflammatory Myopathies

20.1. Polymyositis

20.2. Dermatomyositis

20.3. Immune-Mediated Necrotizing Myopathies

20.4. Overlap myositis

20.5. Inclusion body myositis

20.6. Granulomatous myositis

20.7. Treated myositis in muscle biopsy

Chapter 21: Chronic Denervation Myopathies with Ahmed Bamaga

21.1. Chronic denervation atrophy

21.2. Spinal muscular atrophy

Chapter 22: Axial Myopathy

Chapter 23: Fasciitis

Section C Nerve

Chapter 24: Classification of Neuropathy

Chapter 25: Diagnostic Approach in Nerve Biopsy

Chapter 26: Axonal Neuropathy

Chapter 27: Demyelinating Neuropathy

Chapter 28: Cellular and Extracellular Abnormalities

Chapter 29: Inflammatory Demyelination

29.1. Acute Inflammatory Demyelinating Neuropathy

29.2. Chronic Inflammatory Demyelinating Neuropathy

Chapter 30: Other Common Peripheral Neuropathies




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Maher Kurdi, MD, FRCPC, EFN

Clinical Assistant Professor

Department of Pathology

Faculty of Medicine in Rabigh

King Abdulaziz University

Kingdom of Saudi Arabia