Neurons and the DHA Principle: 1st Edition (Paperback) book cover

Neurons and the DHA Principle

1st Edition

By Raymond C. Valentine, David L. Valentine

CRC Press

287 pages

Purchasing Options:$ = USD
Paperback: 9780367380748
pub: 2019-07-31
SAVE ~$14.99
Available for pre-order
$74.95
$59.96
x
Hardback: 9781439874868
pub: 2012-10-26
SAVE ~$39.00
$195.00
$156.00
x
eBook (VitalSource) : 9780429105203
pub: 2012-10-26
from $28.98


FREE Standard Shipping!

Description

Studies with bacteria and other systems suggest that the omega-3 fatty acid DHA confers great benefits to neurons in maximizing both speed of neural impulses and energy efficiency. Unfortunately, studies also show that DHA’s ease of oxidation damages membrane integrity. Exploring this duality, Neurons and the DHA Principle proposes a new model for the causes of neurodegeneration, in which DHA-enriched membranes of neurons become dysfunctional and energetically wasteful, triggering the premature death of neurons.





The challenge of this book is to digest how DHA acts as an essential building block of neurons while also conspiring for their assassination during aging. As the book reviews the extraordinary properties of DHA in life forms from deep-sea bacteria to human neurons, it asks:







  • Is there a trade-off between speed and efficiency of brain function enabled by DHA versus longevity or life span?


  • Has modern medicine advanced significantly in the treatment of the body but not necessarily of the brain?


  • What are the molecular explanations for the decline in brain health during the age of longevity?






A full accounting of the roles of DHA in neurons requires balancing the enormous benefits of these molecules against the risks. Introducing the dual chemical personalities of DHA from an evolutionary perspective, Neurons and the DHA Principle explores DHA from the standpoint of benefit–risk analysis, opening new perspectives for understanding how DHA functions in neurons.

Table of Contents

Evolution and Essential Roles of DHA in Neurons. Benefits of DHA. Risks of DHA. Revised Membrane Pacemaker Theory of Aging and Age-dependant Diseases. DHA Links Aging and Neurodegeneration.

About the Authors

Raymond C. Valentine is a Visiting Scholar at University of California, Santa Barbara and Professor Emeritus at the University of California, Davis. David L. Valentine is a Professor of Earth Science at the University of California, Santa Barbara.

Subject Categories

BISAC Subject Codes/Headings:
MED060000
MEDICAL / Nutrition
SCI013000
SCIENCE / Chemistry / General
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI089000
SCIENCE / Life Sciences / Neuroscience