Neuropeptides in Neuroprotection and Neuroregeneration: 1st Edition (Hardback) book cover

Neuropeptides in Neuroprotection and Neuroregeneration

1st Edition

Edited by Fred Nyberg

CRC Press

319 pages | 4 Color Illus. | 81 B/W Illus.

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Hardback: 9781439830628
pub: 2012-06-19
eBook (VitalSource) : 9780429094385
pub: 2012-06-19
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Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration.

The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers:

  • General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors
  • Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology
  • Neuropeptides known for their impact in neurodegenerative and neuroprotective processes
  • Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Table of Contents

The Neuropeptide Systems—Some Basic Concepts

Tomas Hökfelt, Zhi-Qing David Xu, Tiejun Shi, Csaba Adori, Kang Zheng, Swapnali Barde, and Mingdong Zhang

Neuropeptide Biosynthesis

Margery C. Beinfeld

Neuropeptide Degradation Related to the Expression of Physiological Action of Neuropeptide

Chikai Sakurada, Hirokazu Mizoguchi, Takaaki Komatsu, Shinobu Sakurada, and Tsukasa Sakurada

Neuropeptides, Isolation, Identification, and Quantitation

Jolanta Kotlinska and Jerzy Silberring

Cellular and Molecular Processes of Neuronal Damage and Protective Mechanisms in Neuroprotection and Neuroregeneration. What General Messages Can We Learn from the Situation after Brain Ischemia?

Gregor Zündorf, Daniel Förster, and Georg Reiser

Dynorphins in Central Nervous System Pathology

Kurt F. Hauser, Pamela E. Knapp, Tatiana Yakovleva, Dineke S. Verbeek, and Georgy Bakalkin

Postnatal Stress Procedures Induce Long-Term Endocrine and Metabolic Alterations Involving Different Proopiomelanocortin-Derived Peptides

Alberto Loizzo, Gabriele Campana, Stefano Loizzo, and Santi Spampinato

Prothymosin α—A Novel Endogenous Neuroprotective Polypeptide against Ischemic Damages Hiroshi Ueda, Hayato Matsunaga, and Sebok K. Halder

Influence of Anabolic Androgenic Steroids on Dynorphinergic Pathways in the Rat Brain

Kristina Magnusson

Angiotensin II Receptors and Neuroprotection

Robert E. Widdop, U. Muscha Steckelings, Claudia A. McCarthy, and Jennifer K. Callaway

PACAP and Cellular Protection: Cellular Protection by Members of the VIP/Secretin Family with an Emphasis on Pituitary Adenylate Cyclase-Activating Polypeptide

Lee E. Eiden

General Strategies of Peptide Synthesis

Aleksandra Misicka

Addressing the Interactions between Opioid Ligands and Their Receptors: Classic and Nonclassic Cases

Luca Gentilucci

Use of Peptides as Drug Leads—A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain

Rebecca Fransson and Anja Sandström

Cognition-Enhancing Peptides and Peptidomimetics

Fred Nyberg and Mathias Hallberg

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Neurology
MEDICAL / Pharmacology
SCIENCE / Chemistry / General
SCIENCE / Life Sciences / Neuroscience