Neuroprosthetics: Principles and Applications, 1st Edition (Paperback) book cover

Neuroprosthetics

Principles and Applications, 1st Edition

By Justin C. Sanchez

CRC Press

236 pages | 115 B/W Illus.

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Paperback: 9781138749443
pub: 2017-07-26
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Description

Master the tools of design thinking using Neuroprosthetics: Principles and Applications.Developed from successfully tested material used in an undergraduate and graduate level course taught to biomedical engineering and neuroscience students,this book focuses on the use of direct neural sensing and stimulation as a therapeutic intervention for complex disorders of the brain. It covers the theory and applications behind neuroprosthetics and explores how neuroprosthetic design thinking can enhance value for users of a direct neural interface.

The book explains the fundamentals of design thinking, introduces essential concepts from neuroscience and engineering illustrating the major components of neuroprosthetics, and presents practical applications. In addition to describing the approach of design thinking (based on facts about the user’s needs, desires, habits, attitudes, and experiences with neuroprosthetics), it also examines how effectively "human centered" neuroprosthetics can address people’s needs and interactions in their daily lives.

Identifying concepts and features of devices that work well with users of a direct neural interface, this book:

  • Outlines the signal sensing capabilities and trade-offs for common electrode designs, and determines the most appropriate electrode for any neuroprosthetic application
  • Specifies neurosurgical techniques and how electronics should be tailored to capture neural signals
  • Provides an understanding of the mechanisms of neural–electrode performance and information contained in neural signals
  • Provides understanding of neural decoding in neuroprosthetic applications
  • Describes the strategies that can be used to promote long-term therapeutic interventions for humans through the use of neuroprosthetics

The first true primary text for undergraduate and graduate students in departments of neuroscience and bioengineering that covers the theory and applications behind this science, Neuroprosthetics: Principles and Applications provides the fundamental knowledge needed to understand how electrodes translate neural activity into signals that are useable by machines and enables readers to master the tools of design thinking and apply them to any neuroprosthetic application.

Table of Contents

Design Thinking for Neuroprosthetics

Learning Objectives

Introduction

Design Thinking

Inspiration for Neuroprosthetic Design

Prototypical Example of Neuroprosthetic Design Thinking

Exercise

Interfaces to the Brain

Learning Objectives

Introduction

Electrical Interfaces

Electrode Design

Exercises

Electronics for Recording

Learning Objectives

Introduction

Use of Sensors

What Is a Signal?

What Is Noise?

Biopotential Amplifiers

Filtering

Adaptive Filters

Conclusion

Exercises

Surgical Techniques for Implantation and Explanation of Microelectrode Arrays

Learning Objectives

Introduction

Targeting

Surgical Methods for Implantation

Surgical Methods for Perfusion

Surgical Methods for Explanation

Exercises

Quantifying Long-Term Electrode Performance

Learning Objectives

Introduction

Morphological Properties

Electrical Properties

Tissue Properties

Holistic Abiotic and Biotic Analysis

Conclusion

Exercises

Neural Decoding

Learning Objectives

Introduction

Evolution of Decoders

Extracting Neural Features as Control Signals

Examples of Neuroprosthetic Decoders

Exercises

Principles of Stimulation

Learning Objectives

Introduction

Nerve Responses to Electrical Current

Strength–Duration Curves

Current Flow

Current Types

Example Applications

Exercises

Application: Brain-Actuated Functional Electrical Stimulation for Rehabilitation

Learning Objectives

Introduction

Hand Rehabilitation Strategies

Fundamentals of Functional Electrical Stimulation

Functional Outcome Measures

An Exemplar of Closed-Loop Neuroprosthetic Control of FES

Closed-Loop Trials

Conclusion

Exercises

Design of Implantable Neural Interface Systems

Learning Objectives

Introduction

Design

Safety

Exercises

Application: Deep Brain Stimulation for Neuropsychiatric Disorders

Learning Objectives

Introduction

DBS as a Foundational Technology

Shifts in Research/Practice Paradigms

Second-Generation Experimental Paradigms—Application of DBS for Tourette Syndrome

Conclusion

Exercise

References

About the Author

Justin C. Sanchez is a neurotechnologist, neuroscientist, and neural engineer. He has served as a program manager at DARPA and before that was an associate professor of biomedical engineering and neuroscience at the University of Miami, and a faculty member of the Miami Project to Cure Paralysis. He has published more than 75 peer-reviewed papers, holds seven patents in neuroprosthetic design, and authored a book on the design of brain–machine interfaces. Dr. Sanchez’s degrees include a Doctor of Philosophy, Master of Engineering, and Bachelor of Science, all from the University of Florida, Gainesville.

About the Series

Rehabilitation Science in Practice Series

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Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
SCI089000
SCIENCE / Life Sciences / Neuroscience