1040 Pages 100 B/W Illustrations
    by CRC Press

    1040 Pages 100 B/W Illustrations
    by CRC Press

    Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition, details steps developing countries have taken toward research, development, manufacture, and regulation of several new vaccines for widespread use.

    This text will:

    • cover the current state-of-the-art techniques in vaccine development – including the successes and the failures
    • trace vaccine development from the bench to public health with regard to both FDA and European Union regulations
    • investigate improved methods for immunizing large populations, and the use of needless vaccinations
    • discuss the advancements in the heavily government-funded areas for developing vaccines against potential bioterror and infectious disease agents as well as the immunization of large population bases for diseases like: Anthrax, Smallpox, Ebola, West Nile, SARS, and others

    Updated throughout with new cutting-edge information on recent breakthroughs and developments.


    • highlights the latest activities of prominent organizations in the vaccine industry
    • covers the current techniques in vaccine development
    • investigates improved methods for immunizing large populations

    Vaccines and Vaccination in Historical Perspective, Myron M. Levine, Rosanna Lagos, and Jose´ Esparza
    Developing Vaccines in the Era of Reverse Vaccinology, Rino Rappuoli, Gordon Dougan, and Isabel Delany
    Initial Clinical Evaluation of New Vaccine Candidates, Carol O. Tacket and Karen L. Kotloff
    Special Issues in Performing Vaccine Trials in Developing Countries, Milagritos D. Tapia, Karen L. Kotloff, Christopher V. Plowe, and Samba O. Sow
    Long-Term Evaluation of Vaccine Performance: Methodological, Issues for Phase III and Phase IV Studies, John D. Clemens, Abdollah Naficy, Malla R. Rao, and Hye-won Koo
    Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries , Charles Weijer, Claudio F. Lanata, and Christopher V. Plowe
    Vaccine Economics: Assuring That Vaccines Are Developed for and Available in Developing Countries, Amie Batson and Piers Whitehead
    Development and Supply of Vaccines: An Industry Perspective, Michel Gre´co and Luc Hessel
    Reaching Every Child: Achieving Equity in Global Immunization, R. Bruce Aylward, B. Melgaard, M. Birmingham, J. Lloyd, R. Eggers, J. Bilous, and T. Cherian
    A Paradigm for International Cooperation: The GAVI Alliance, Lisa Jacobs
    Economic Analyses of Vaccines and Vaccination Programs, Benjamin Schwartz and Mark L. Messonier
    An Overview of U.S. Food and Drug Administration Licensure of Vaccines, Lydia A. Falk, Norman Baylor, and Karen Midthun
    Assuring Vaccine Quality by Strengthening Regulatory Agencies, The Work of the World Health Organization, Julie Milstien, Nora Dellepiane, Lahouari Belgharbi, Liliana Chocarro, and David Wood
    Vaccine Safety, Neal A. Halsey, Robert Ball, and Leslie K. Ball
    Manufacturing of Vaccines, Guido Dietrich, Julie Milstien, Suresh Jadhav, and Peter C. Stowe
    Polio Eradication: Ongoing Innovation to End an Ancient Scourge, R. Bruce Aylward, Stephen L. Cochi, and David L. Heymann
    Recent Advances in Immunology That Impact Vaccine Development, Marcelo B. Sztein, Rafi Ahmed, and Shane Crotty
    Modulating Vaccine Responses with Innate Immunity, Bali Pulendran, Jeff Powell, and Richard A. Flavell
    Immunodominance, Deceptive Imprinting, and Immune Refocusing Technology, Peter L. Nara and George Lin
    Standardization and High-Throughput Measurement of T-Cell Responses to Vaccines, Kent J. Weinhold and Janet S. Ottinger
    Transition to High-Throughput Laboratory Assays to Evaluate Multivalent Vaccines, Sandra Romero-Steiner, George M. Carlone, Helen Baxendale, and David Goldblatt
    The Challenge of Vaccine Protection in Very Young Infants, Claire-Anne Siegrist
    The Challenge of Inducing Vaccine Protection in the Elderly, Dietmar Herndler-Brandstetter, Angelika Schwanninger, and Beatrix Grubeck-Loebenstein
    Vaccination and Autoimmunity, Paul-Henri Lambert and Michel Goldman
    Adjuvants for the Future, Richard T. Kenney and Alan S. Cross
    TLR Agonists for Immune Enhancement of Vaccines, Heather L. Davis
    Use of Genetically or Chemically Detoxified Mutants of Cholera and Escherichia coli Heat-Labile Enterotoxins as Mucosal Adjuvants., Lucy C. Freytag, John D. Clements, Dubravka Grdic Eliasson, and Nils Lycke
    Recent Developments in Nonliving Antigen Delivery Systems, Derek T. O’Hagan
    Virus-Like Particles as Vaccines and Vaccine Delivery Systems, Kathrin U. Jansen, Margaret E. Conner, and Mary K. Estes
    Subunit Vaccines Produced Using Plant Biotechnology, Qiang Chen, Hugh S. Mason, Tsafrir Mor, Alec Sutherland, Guy A. Cardineau, Charles J. Arntzen, and Carol O. Tacket
    Lipopeptide-Based Vaccines, David C. Jackson, Brendon Y. Chua, Lorena E. Brown, Peter Moyle, and Istvan Toth
    Vaccines Based on Dendritic Cell Biology, Silvia B. Boscardin, Michel C. Nussenzweig, Christine Trumpfheller, and Ralph M. Steinman
    Vaccinia Virus and Other Poxviruses as Live Vectors, Bernard Moss
    Replication-Defective and Competent Adenovirus Recombinants as Vaccine Vectors, Marjorie Robert-Guroff, Gary J. Nabel, and John W. Shiver
    RNA Virus Replicon Vaccines, Nancy L. Davis and Robert E. Johnston
    Engineering of Attenuated Salmonella enterica Serovars for Use as Live Vector Vaccines, James E. Galen, Marcela F. Pasetti, Sharon Tennant, Marcelo B. Sztein, and Myron M. Levine
    DNA Vaccines, Gary J. Nabel, David C. Kaslow, Jeffrey B. Ulmer, and Margaret A. Liu
    Overview of Heterologous Prime-Boost Immunization Strategies, Helen McShane, Adrian V. S. Hill, and Andrew McMichael
    Mucosal Immunization and Needle-Free Injection Devices, Jakub K. Simon, Myron M. Levine, Bruce G. Weniger, and Ana M. H. Restrepo
    Advances in Transcutaneous Vaccine Delivery, Robert C. Seid, Jr. and Gregory M. Glenn
    Rationalizing Childhood Immunization Programs: The Variation in Schedules and Use of Combination Vaccines, Andrew J. Pollard, Kathryn M. Edwards, and Bernard Fritzell
    Meningococcal Conjugate and Protein-Based Vaccines, Andrew J. Pollard, E. Richard Moxon, and Rino Rappuoli
    Post-Licensure Impact of Haemophilus influenzae Type b and Serogroup C Neisseria meningitidis Conjugate Vaccines in Industrialized Countries, Elizabeth Miller, Helen Campbell, and Mary Ramsay
    Haemophilus influenzae Type b Disease Burden and the Impact of Programmatic Infant Immunization in Developing Countries, Richard A. Adegbola, Samba O. Sow, and J. Anthony G. Scott
    Pneumococcal Protein-Polysaccharide Conjugate Vaccines, Cynthia G. Whitney and Orin S. Levine
    Pneumococcal Common Proteins and Other Vaccine Strategies, David E. Briles, James C. Paton, Susan K. Hollingshead, and John W. Boslego
    Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, and Escherichia coli O:H, Shousun C. Szu, John. B. Robbins, Rachel Schneerson, and F.-Y. Lin
    Attenuated Strains of Salmonella enterica Serovars Typhi and Paratyphi as Live Oral Vaccines Against Enteric Fever, Myron M. Levine, James E. Galen, Marcela F. Pasetti, and Marcelo B. Sztein
    Oral Cholera Vaccines, Jan Holmgren and James B. Kaper
    Novel Vaccines Against Tuberculosis, Marcus A. Horwitz, Peter Andersen, and Stefan H. E. Kaufmann
    Influenza, John Treanor, Wendy Keitel, and Iain Stephenson
    Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile, Konstantin V. Pugachev, Farshad Guirakhoo, Dennis W. Trent, and Thomas P. Monath
    Vaccines Against Rotavirus Gastroenteritis, Richard L. Ward, H. Fred Clark, Paul A. Offit, Umesh D. Parashar, and Roger I. Glass
    Novel Strategies for Immunizing Infants in Developing Countries Who Are Too Young to Receive the Currently Licensed Measles Vaccines, Marcela F. Pasetti, Karina Ramirez, Karen L. Kotloff, Eileen M. Barry, and Myron M. Levine
    Challenges and Prospects for the Development of an HIV Vaccine, Barney S. Graham and Gary J. Nabel
    Vaccine Strategies to Prevent Dengue, Robert Edelman, Stephen S. Whitehead, and David W. Vaughn
    Vaccination Against the Hepatitis C Virus, Sergio Abrignani, Raffaele De Francesco, and Michael Houghton
    Vaccines Against Respiratory Syncytial Virus and Parainfluenza Viruses, Alexander Schmidt, Emmalene Bartlett, Anne Schaap-Nutt, Peter L. Collins, Brian R. Murphy, and Ruth Karron
    Cytomegalovirus Vaccines, David I. Bernstein and Stanley A. Plotkin
    Epstein–Barr Virus Vaccines, Viviana P. Lutzky and Denis J. Moss
    Herpes Simplex Vaccines, David M. Koelle, Lawrence R. Stanberry, Reuben S. Carpenter, and Richard J. Whitley
    Development of Vaccines to Prevent Group A Streptococcal Infections and Rheumatic Fever, J. B. Dale, M. Batzloff, Michael F. Good, J. McCarthy, J. R. Carapetis, P. P. Cleary, V. Fischetti, and J. Zabriski
    Vaccines Against Group B Streptococcus, Morven S. Edwards, Carol J. Baker, and Lawrence C. Paoletti
    Overview of Live and Subcellular Vaccine Strategies Against Shigella,.Karen L. Kotloff, Eileen M. Barry, Myron M. Levine, Thomas L. Hale, and Philippe Sansonetti
    Vaccines Against Enterotoxigenic Escherichia coli, Ann-Mari Svennerholm and Gregory Glenn
    Multivalent Shigella Enterotoxigenic Escherichia coli Vaccine, Eileen M. Barry and Myron M. Levine
    Vaccines for Staphylococcus aureus Infections, Juliane Bubeck Wardenburg, Dominique Missiakas, and Olaf Schneewind
    Chlamydia trachomatis Vaccines, Renata Grifantini and Guido Grandi
    Malaria Vaccines in Clinical Development: Introduction and Recombinant/Subunit Approaches, Laura B. Martin, Robert W. Sauerwein, Teun Bousema, David E. Lanar, and Thomas L. Richie
    Gene-Based Malaria Vaccines, Adrian V. S. Hill

    Pre-erythrocytic and Asexual Erythrocytic Stage Whole-Organism Malaria Vaccines, Stephen L. Hoffman, B. Kim Lee Sim, Adam Richman, Alberto Pinzon-Charry, Michael F. Good, and J. McCarthy
    Vaccines Against Leishmania, Farrokh Modabber, Rhea Coler, and Steven G. Reed
    Vaccines Against Schistosomiasis, Alex Loukas, Jeffrey M. Bethony, Andre´ Capron, and Donald P. McManus
    Vaccines Against Entamoeba histolytica, Christopher D. Huston and William A. Petri, Jr.
    Hookworm Vaccines, Jeffrey M. Bethony, Maria Elena Bottazzi, Ami Shah Brown, David Diemert, Peter Hotez, and Alex Loukas
    Improved Smallpox Vaccines, Matthew E. Cohen and Stuart N. Isaacs
    Anthrax Vaccines, Arthur M. Friedlander, Stephen F. Little, and Marc Gurwith
    Tularemia Vaccines, Alan S. Cross and Eileen M. Barry
    Vaccines Against Plague, Scott A. Lloyd
    Development of Vaccines for Ebola and Marburg Viruses: Efficacy and Regulatory Considerations, Gary J. Nabel
    Therapeutics and Vaccines Against Hendra and Nipah Viruses, Christopher C. Broder
    Vaccines Against Lassa Fever, Maria S. Salvato and Igor S. Lukashevich
    Hantavirus Vaccines, Christopher D. Hammerbeck and Jay W. Hooper
    SARS Vaccines, Kanta Subbarao
    Cancer-Specific Vaccines, Drew Pardoll
    Vaccines Against Human Papillomaviruses, Kathrin U. Jansen and Ian H. Frazer
    Vaccines Against Alzheimer’s and Other Neurodegenerative Diseases, Roy M. Robins-Browne and Colin L. Masters
    Vaccination for Autoimmune and Other Chronic, Inflammatory Disorders, Leonard C. Harrison
    Immunotherapies To Treat Drug Addiction., Paul R. Pentel, Dan E. Keyler, and Thomas R. Kosten


    Myrone M. Levine, Gordon Dougan, Michael F. Good, Gary J. Nabel, James P. Nataro, Rino Rappuoli