New Generation Vaccines  book cover
4th Edition

New Generation Vaccines

ISBN 9781138113824
Published July 13, 2017 by CRC Press
1040 Pages 100 B/W Illustrations

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Book Description

Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition, details steps developing countries have taken toward research, development, manufacture, and regulation of several new vaccines for widespread use.

This text will:

  • cover the current state-of-the-art techniques in vaccine development – including the successes and the failures
  • trace vaccine development from the bench to public health with regard to both FDA and European Union regulations
  • investigate improved methods for immunizing large populations, and the use of needless vaccinations
  • discuss the advancements in the heavily government-funded areas for developing vaccines against potential bioterror and infectious disease agents as well as the immunization of large population bases for diseases like: Anthrax, Smallpox, Ebola, West Nile, SARS, and others

Updated throughout with new cutting-edge information on recent breakthroughs and developments.


  • highlights the latest activities of prominent organizations in the vaccine industry
  • covers the current techniques in vaccine development
  • investigates improved methods for immunizing large populations

Table of Contents

Vaccines and Vaccination in Historical Perspective, Myron M. Levine, Rosanna Lagos, and Jose´ Esparza
Developing Vaccines in the Era of Reverse Vaccinology, Rino Rappuoli, Gordon Dougan, and Isabel Delany
Initial Clinical Evaluation of New Vaccine Candidates, Carol O. Tacket and Karen L. Kotloff
Special Issues in Performing Vaccine Trials in Developing Countries, Milagritos D. Tapia, Karen L. Kotloff, Christopher V. Plowe, and Samba O. Sow
Long-Term Evaluation of Vaccine Performance: Methodological, Issues for Phase III and Phase IV Studies, John D. Clemens, Abdollah Naficy, Malla R. Rao, and Hye-won Koo
Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries , Charles Weijer, Claudio F. Lanata, and Christopher V. Plowe
Vaccine Economics: Assuring That Vaccines Are Developed for and Available in Developing Countries, Amie Batson and Piers Whitehead
Development and Supply of Vaccines: An Industry Perspective, Michel Gre´co and Luc Hessel
Reaching Every Child: Achieving Equity in Global Immunization, R. Bruce Aylward, B. Melgaard, M. Birmingham, J. Lloyd, R. Eggers, J. Bilous, and T. Cherian
A Paradigm for International Cooperation: The GAVI Alliance, Lisa Jacobs
Economic Analyses of Vaccines and Vaccination Programs, Benjamin Schwartz and Mark L. Messonier
An Overview of U.S. Food and Drug Administration Licensure of Vaccines, Lydia A. Falk, Norman Baylor, and Karen Midthun
Assuring Vaccine Quality by Strengthening Regulatory Agencies, The Work of the World Health Organization, Julie Milstien, Nora Dellepiane, Lahouari Belgharbi, Liliana Chocarro, and David Wood
Vaccine Safety, Neal A. Halsey, Robert Ball, and Leslie K. Ball
Manufacturing of Vaccines, Guido Dietrich, Julie Milstien, Suresh Jadhav, and Peter C. Stowe
Polio Eradication: Ongoing Innovation to End an Ancient Scourge, R. Bruce Aylward, Stephen L. Cochi, and David L. Heymann
Recent Advances in Immunology That Impact Vaccine Development, Marcelo B. Sztein, Rafi Ahmed, and Shane Crotty
Modulating Vaccine Responses with Innate Immunity, Bali Pulendran, Jeff Powell, and Richard A. Flavell
Immunodominance, Deceptive Imprinting, and Immune Refocusing Technology, Peter L. Nara and George Lin
Standardization and High-Throughput Measurement of T-Cell Responses to Vaccines, Kent J. Weinhold and Janet S. Ottinger
Transition to High-Throughput Laboratory Assays to Evaluate Multivalent Vaccines, Sandra Romero-Steiner, George M. Carlone, Helen Baxendale, and David Goldblatt
The Challenge of Vaccine Protection in Very Young Infants, Claire-Anne Siegrist
The Challenge of Inducing Vaccine Protection in the Elderly, Dietmar Herndler-Brandstetter, Angelika Schwanninger, and Beatrix Grubeck-Loebenstein
Vaccination and Autoimmunity, Paul-Henri Lambert and Michel Goldman
Adjuvants for the Future, Richard T. Kenney and Alan S. Cross
TLR Agonists for Immune Enhancement of Vaccines, Heather L. Davis
Use of Genetically or Chemically Detoxified Mutants of Cholera and Escherichia coli Heat-Labile Enterotoxins as Mucosal Adjuvants., Lucy C. Freytag, John D. Clements, Dubravka Grdic Eliasson, and Nils Lycke
Recent Developments in Nonliving Antigen Delivery Systems, Derek T. O’Hagan
Virus-Like Particles as Vaccines and Vaccine Delivery Systems, Kathrin U. Jansen, Margaret E. Conner, and Mary K. Estes
Subunit Vaccines Produced Using Plant Biotechnology, Qiang Chen, Hugh S. Mason, Tsafrir Mor, Alec Sutherland, Guy A. Cardineau, Charles J. Arntzen, and Carol O. Tacket
Lipopeptide-Based Vaccines, David C. Jackson, Brendon Y. Chua, Lorena E. Brown, Peter Moyle, and Istvan Toth
Vaccines Based on Dendritic Cell Biology, Silvia B. Boscardin, Michel C. Nussenzweig, Christine Trumpfheller, and Ralph M. Steinman
Vaccinia Virus and Other Poxviruses as Live Vectors, Bernard Moss
Replication-Defective and Competent Adenovirus Recombinants as Vaccine Vectors, Marjorie Robert-Guroff, Gary J. Nabel, and John W. Shiver
RNA Virus Replicon Vaccines, Nancy L. Davis and Robert E. Johnston
Engineering of Attenuated Salmonella enterica Serovars for Use as Live Vector Vaccines, James E. Galen, Marcela F. Pasetti, Sharon Tennant, Marcelo B. Sztein, and Myron M. Levine
DNA Vaccines, Gary J. Nabel, David C. Kaslow, Jeffrey B. Ulmer, and Margaret A. Liu
Overview of Heterologous Prime-Boost Immunization Strategies, Helen McShane, Adrian V. S. Hill, and Andrew McMichael
Mucosal Immunization and Needle-Free Injection Devices, Jakub K. Simon, Myron M. Levine, Bruce G. Weniger, and Ana M. H. Restrepo
Advances in Transcutaneous Vaccine Delivery, Robert C. Seid, Jr. and Gregory M. Glenn
Rationalizing Childhood Immunization Programs: The Variation in Schedules and Use of Combination Vaccines, Andrew J. Pollard, Kathryn M. Edwards, and Bernard Fritzell
Meningococcal Conjugate and Protein-Based Vaccines, Andrew J. Pollard, E. Richard Moxon, and Rino Rappuoli
Post-Licensure Impact of Haemophilus influenzae Type b and Serogroup C Neisseria meningitidis Conjugate Vaccines in Industrialized Countries, Elizabeth Miller, Helen Campbell, and Mary Ramsay
Haemophilus influenzae Type b Disease Burden and the Impact of Programmatic Infant Immunization in Developing Countries, Richard A. Adegbola, Samba O. Sow, and J. Anthony G. Scott
Pneumococcal Protein-Polysaccharide Conjugate Vaccines, Cynthia G. Whitney and Orin S. Levine
Pneumococcal Common Proteins and Other Vaccine Strategies, David E. Briles, James C. Paton, Susan K. Hollingshead, and John W. Boslego
Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, and Escherichia coli O:H, Shousun C. Szu, John. B. Robbins, Rachel Schneerson, and F.-Y. Lin
Attenuated Strains of Salmonella enterica Serovars Typhi and Paratyphi as Live Oral Vaccines Against Enteric Fever, Myron M. Levine, James E. Galen, Marcela F. Pasetti, and Marcelo B. Sztein
Oral Cholera Vaccines, Jan Holmgren and James B. Kaper
Novel Vaccines Against Tuberculosis, Marcus A. Horwitz, Peter Andersen, and Stefan H. E. Kaufmann
Influenza, John Treanor, Wendy Keitel, and Iain Stephenson
Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile, Konstantin V. Pugachev, Farshad Guirakhoo, Dennis W. Trent, and Thomas P. Monath
Vaccines Against Rotavirus Gastroenteritis, Richard L. Ward, H. Fred Clark, Paul A. Offit, Umesh D. Parashar, and Roger I. Glass
Novel Strategies for Immunizing Infants in Developing Countries Who Are Too Young to Receive the Currently Licensed Measles Vaccines, Marcela F. Pasetti, Karina Ramirez, Karen L. Kotloff, Eileen M. Barry, and Myron M. Levine
Challenges and Prospects for the Development of an HIV Vaccine, Barney S. Graham and Gary J. Nabel
Vaccine Strategies to Prevent Dengue, Robert Edelman, Stephen S. Whitehead, and David W. Vaughn
Vaccination Against the Hepatitis C Virus, Sergio Abrignani, Raffaele De Francesco, and Michael Houghton
Vaccines Against Respiratory Syncytial Virus and Parainfluenza Viruses, Alexander Schmidt, Emmalene Bartlett, Anne Schaap-Nutt, Peter L. Collins, Brian R. Murphy, and Ruth Karron
Cytomegalovirus Vaccines, David I. Bernstein and Stanley A. Plotkin
Epstein–Barr Virus Vaccines, Viviana P. Lutzky and Denis J. Moss
Herpes Simplex Vaccines, David M. Koelle, Lawrence R. Stanberry, Reuben S. Carpenter, and Richard J. Whitley
Development of Vaccines to Prevent Group A Streptococcal Infections and Rheumatic Fever, J. B. Dale, M. Batzloff, Michael F. Good, J. McCarthy, J. R. Carapetis, P. P. Cleary, V. Fischetti, and J. Zabriski
Vaccines Against Group B Streptococcus, Morven S. Edwards, Carol J. Baker, and Lawrence C. Paoletti
Overview of Live and Subcellular Vaccine Strategies Against Shigella,.Karen L. Kotloff, Eileen M. Barry, Myron M. Levine, Thomas L. Hale, and Philippe Sansonetti
Vaccines Against Enterotoxigenic Escherichia coli, Ann-Mari Svennerholm and Gregory Glenn
Multivalent Shigella Enterotoxigenic Escherichia coli Vaccine, Eileen M. Barry and Myron M. Levine
Vaccines for Staphylococcus aureus Infections, Juliane Bubeck Wardenburg, Dominique Missiakas, and Olaf Schneewind
Chlamydia trachomatis Vaccines, Renata Grifantini and Guido Grandi
Malaria Vaccines in Clinical Development: Introduction and Recombinant/Subunit Approaches, Laura B. Martin, Robert W. Sauerwein, Teun Bousema, David E. Lanar, and Thomas L. Richie
Gene-Based Malaria Vaccines, Adrian V. S. Hill

Pre-erythrocytic and Asexual Erythrocytic Stage Whole-Organism Malaria Vaccines, Stephen L. Hoffman, B. Kim Lee Sim, Adam Richman, Alberto Pinzon-Charry, Michael F. Good, and J. McCarthy
Vaccines Against Leishmania, Farrokh Modabber, Rhea Coler, and Steven G. Reed
Vaccines Against Schistosomiasis, Alex Loukas, Jeffrey M. Bethony, Andre´ Capron, and Donald P. McManus
Vaccines Against Entamoeba histolytica, Christopher D. Huston and William A. Petri, Jr.
Hookworm Vaccines, Jeffrey M. Bethony, Maria Elena Bottazzi, Ami Shah Brown, David Diemert, Peter Hotez, and Alex Loukas
Improved Smallpox Vaccines, Matthew E. Cohen and Stuart N. Isaacs
Anthrax Vaccines, Arthur M. Friedlander, Stephen F. Little, and Marc Gurwith
Tularemia Vaccines, Alan S. Cross and Eileen M. Barry
Vaccines Against Plague, Scott A. Lloyd
Development of Vaccines for Ebola and Marburg Viruses: Efficacy and Regulatory Considerations, Gary J. Nabel
Therapeutics and Vaccines Against Hendra and Nipah Viruses, Christopher C. Broder
Vaccines Against Lassa Fever, Maria S. Salvato and Igor S. Lukashevich
Hantavirus Vaccines, Christopher D. Hammerbeck and Jay W. Hooper
SARS Vaccines, Kanta Subbarao
Cancer-Specific Vaccines, Drew Pardoll
Vaccines Against Human Papillomaviruses, Kathrin U. Jansen and Ian H. Frazer
Vaccines Against Alzheimer’s and Other Neurodegenerative Diseases, Roy M. Robins-Browne and Colin L. Masters
Vaccination for Autoimmune and Other Chronic, Inflammatory Disorders, Leonard C. Harrison
Immunotherapies To Treat Drug Addiction., Paul R. Pentel, Dan E. Keyler, and Thomas R. Kosten

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