New Generation Vaccines: 4th Edition (Paperback) book cover

New Generation Vaccines

4th Edition

Edited by Myrone M. Levine, Myron M. Levine, Gordon Dougan, Michael F. Good, Margaret A. Liu, Gary J. Nabel, James P. Nataro, Rino Rappuoli

CRC Press

1,040 pages | 100 B/W Illus.

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Description

Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition,details steps developing countries have taken toward research, development, manufacture, and regulation of several new vaccines for widespread use.

This text will:

  • cover the current state-of-the-art techniques in vaccine development – including the successes and the failures
  • trace vaccine development from the bench to public health with regard to both FDA and European Union regulations
  • investigate improved methods for immunizing large populations, and the use of needless vaccinations
  • discuss the advancements in the heavily government-funded areas for developing vaccines against potential bioterror and infectious disease agents as well as the immunization of large population bases for diseases like: Anthrax, Smallpox, Ebola, West Nile, SARS, and others

Updated throughout with new cutting-edge information on recent breakthroughs and developments.

NEW TO GENERATION VACCINES, FOURTH EDITION:

  • highlights the latest activities of prominent organizations in the vaccine industry
  • covers the current techniques in vaccine development
  • investigates improved methods for immunizing large populations

Table of Contents

Vaccines and Vaccination in Historical Perspective, Myron M. Levine, Rosanna Lagos, and Jose´ Esparza

Developing Vaccines in the Era of Reverse Vaccinology, Rino Rappuoli, Gordon Dougan, and Isabel Delany

Initial Clinical Evaluation of New Vaccine Candidates, Carol O. Tacket and Karen L. Kotloff

Special Issues in Performing Vaccine Trials in Developing Countries, Milagritos D. Tapia, Karen L. Kotloff, Christopher V. Plowe, and Samba O. Sow

Long-Term Evaluation of Vaccine Performance: Methodological, Issues for Phase III and Phase IV Studies, John D. Clemens, Abdollah Naficy, Malla R. Rao, and Hye-won Koo

Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries , Charles Weijer, Claudio F. Lanata, and Christopher V. Plowe

Vaccine Economics: Assuring That Vaccines Are Developed for and Available in Developing Countries, Amie Batson and Piers Whitehead

Development and Supply of Vaccines: An Industry Perspective, Michel Gre´co and Luc Hessel

Reaching Every Child: Achieving Equity in Global Immunization, R. Bruce Aylward, B. Melgaard, M. Birmingham, J. Lloyd, R. Eggers, J. Bilous, and T. Cherian

A Paradigm for International Cooperation: The GAVI Alliance, Lisa Jacobs

Economic Analyses of Vaccines and Vaccination Programs, Benjamin Schwartz and Mark L. Messonier

An Overview of U.S. Food and Drug Administration Licensure of Vaccines, Lydia A. Falk, Norman Baylor, and Karen Midthun

Assuring Vaccine Quality by Strengthening Regulatory Agencies, The Work of the World Health Organization, Julie Milstien, Nora Dellepiane, Lahouari Belgharbi, Liliana Chocarro, and David Wood

Vaccine Safety, Neal A. Halsey, Robert Ball, and Leslie K. Ball

Manufacturing of Vaccines, Guido Dietrich, Julie Milstien, Suresh Jadhav, and Peter C. Stowe

Polio Eradication: Ongoing Innovation to End an Ancient Scourge, R. Bruce Aylward, Stephen L. Cochi, and David L. Heymann

Recent Advances in Immunology That Impact Vaccine Development, Marcelo B. Sztein, Rafi Ahmed, and Shane Crotty

Modulating Vaccine Responses with Innate Immunity, Bali Pulendran, Jeff Powell, and Richard A. Flavell

Immunodominance, Deceptive Imprinting, and Immune Refocusing Technology, Peter L. Nara and George Lin

Standardization and High-Throughput Measurement of T-Cell Responses to Vaccines, Kent J. Weinhold and Janet S. Ottinger

Transition to High-Throughput Laboratory Assays to Evaluate Multivalent Vaccines, Sandra Romero-Steiner, George M. Carlone, Helen Baxendale, and David Goldblatt

The Challenge of Vaccine Protection in Very Young Infants, Claire-Anne Siegrist

The Challenge of Inducing Vaccine Protection in the Elderly, Dietmar Herndler-Brandstetter, Angelika Schwanninger, and Beatrix Grubeck-Loebenstein

Vaccination and Autoimmunity, Paul-Henri Lambert and Michel Goldman

Adjuvants for the Future, Richard T. Kenney and Alan S. Cross

TLR Agonists for Immune Enhancement of Vaccines, Heather L. Davis

Use of Genetically or Chemically Detoxified Mutants of Cholera and Escherichia coli Heat-Labile Enterotoxins as Mucosal Adjuvants., Lucy C. Freytag, John D. Clements, Dubravka Grdic Eliasson, and Nils Lycke

Recent Developments in Nonliving Antigen Delivery Systems, Derek T. O’Hagan

Virus-Like Particles as Vaccines and Vaccine Delivery Systems, Kathrin U. Jansen, Margaret E. Conner, and Mary K. Estes

Subunit Vaccines Produced Using Plant Biotechnology, Qiang Chen, Hugh S. Mason, Tsafrir Mor, Alec Sutherland, Guy A. Cardineau, Charles J. Arntzen, and Carol O. Tacket

Lipopeptide-Based Vaccines, David C. Jackson, Brendon Y. Chua, Lorena E. Brown, Peter Moyle, and Istvan Toth

Vaccines Based on Dendritic Cell Biology, Silvia B. Boscardin, Michel C. Nussenzweig, Christine Trumpfheller, and Ralph M. Steinman

Vaccinia Virus and Other Poxviruses as Live Vectors, Bernard Moss

Replication-Defective and Competent Adenovirus Recombinants as Vaccine Vectors, Marjorie Robert-Guroff, Gary J. Nabel, and John W. Shiver

RNA Virus Replicon Vaccines, Nancy L. Davis and Robert E. Johnston

Engineering of Attenuated Salmonella enterica Serovars for Use as Live Vector Vaccines, James E. Galen, Marcela F. Pasetti, Sharon Tennant, Marcelo B. Sztein, and Myron M. Levine

DNA Vaccines, Gary J. Nabel, David C. Kaslow, Jeffrey B. Ulmer, and Margaret A. Liu

Overview of Heterologous Prime-Boost Immunization Strategies, Helen McShane, Adrian V. S. Hill, and Andrew McMichael

Mucosal Immunization and Needle-Free Injection Devices, Jakub K. Simon, Myron M. Levine, Bruce G. Weniger, and Ana M. H. Restrepo

Advances in Transcutaneous Vaccine Delivery, Robert C. Seid, Jr. and Gregory M. Glenn

Rationalizing Childhood Immunization Programs: The Variation in Schedules and Use of Combination Vaccines, Andrew J. Pollard, Kathryn M. Edwards, and Bernard Fritzell

Meningococcal Conjugate and Protein-Based Vaccines, Andrew J. Pollard, E. Richard Moxon, and Rino Rappuoli

Post-Licensure Impact of Haemophilus influenzae Type b and Serogroup C Neisseria meningitidis Conjugate Vaccines in Industrialized Countries, Elizabeth Miller, Helen Campbell, and Mary Ramsay

Haemophilus influenzae Type b Disease Burden and the Impact of Programmatic Infant Immunization in Developing Countries, Richard A. Adegbola, Samba O. Sow, and J. Anthony G. Scott

Pneumococcal Protein-Polysaccharide Conjugate Vaccines, Cynthia G. Whitney and Orin S. Levine

Pneumococcal Common Proteins and Other Vaccine Strategies, David E. Briles, James C. Paton, Susan K. Hollingshead, and John W. Boslego

Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, and Escherichia coli O:H, Shousun C. Szu, John. B. Robbins, Rachel Schneerson, and F.-Y. Lin

Attenuated Strains of Salmonella enterica Serovars Typhi and Paratyphi as Live Oral Vaccines Against Enteric Fever, Myron M. Levine, James E. Galen, Marcela F. Pasetti, and Marcelo B. Sztein

Oral Cholera Vaccines, Jan Holmgren and James B. Kaper

Novel Vaccines Against Tuberculosis, Marcus A. Horwitz, Peter Andersen, and Stefan H. E. Kaufmann

Influenza, John Treanor, Wendy Keitel, and Iain Stephenson

Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile, Konstantin V. Pugachev, Farshad Guirakhoo, Dennis W. Trent, and Thomas P. Monath

Vaccines Against Rotavirus Gastroenteritis, Richard L. Ward, H. Fred Clark, Paul A. Offit, Umesh D. Parashar, and Roger I. Glass

Novel Strategies for Immunizing Infants in Developing Countries Who Are Too Young to Receive the Currently Licensed Measles Vaccines, Marcela F. Pasetti, Karina Ramirez, Karen L. Kotloff, Eileen M. Barry, and Myron M. Levine

Challenges and Prospects for the Development of an HIV Vaccine, Barney S. Graham and Gary J. Nabel

Vaccine Strategies to Prevent Dengue, Robert Edelman, Stephen S. Whitehead, and David W. Vaughn

Vaccination Against the Hepatitis C Virus, Sergio Abrignani, Raffaele De Francesco, and Michael Houghton

Vaccines Against Respiratory Syncytial Virus and Parainfluenza Viruses, Alexander Schmidt, Emmalene Bartlett, Anne Schaap-Nutt, Peter L. Collins, Brian R. Murphy, and Ruth Karron

Cytomegalovirus Vaccines, David I. Bernstein and Stanley A. Plotkin

Epstein–Barr Virus Vaccines, Viviana P. Lutzky and Denis J. Moss

Herpes Simplex Vaccines, David M. Koelle, Lawrence R. Stanberry, Reuben S. Carpenter, and Richard J. Whitley

Development of Vaccines to Prevent Group A Streptococcal Infections and Rheumatic Fever, J. B. Dale, M. Batzloff, Michael F. Good, J. McCarthy, J. R. Carapetis, P. P. Cleary, V. Fischetti, and J. Zabriski

Vaccines Against Group B Streptococcus, Morven S. Edwards, Carol J. Baker, and Lawrence C. Paoletti

Overview of Live and Subcellular Vaccine Strategies Against Shigella,.Karen L. Kotloff, Eileen M. Barry, Myron M. Levine, Thomas L. Hale, and Philippe Sansonetti

Vaccines Against Enterotoxigenic Escherichia coli, Ann-Mari Svennerholm and Gregory Glenn

Multivalent Shigella Enterotoxigenic Escherichia coli Vaccine, Eileen M. Barry and Myron M. Levine

Vaccines for Staphylococcus aureus Infections, Juliane Bubeck Wardenburg, Dominique Missiakas, and Olaf Schneewind

Chlamydia trachomatis Vaccines, Renata Grifantini and Guido Grandi

Malaria Vaccines in Clinical Development: Introduction and Recombinant/Subunit Approaches, Laura B. Martin, Robert W. Sauerwein, Teun Bousema, David E. Lanar, and Thomas L. Richie

Gene-Based Malaria Vaccines, Adrian V. S. Hill

Pre-erythrocytic and Asexual Erythrocytic Stage Whole-Organism Malaria Vaccines, Stephen L. Hoffman, B. Kim Lee Sim, Adam Richman, Alberto Pinzon-Charry, Michael F. Good, and J. McCarthy

Vaccines Against Leishmania, Farrokh Modabber, Rhea Coler, and Steven G. Reed

Vaccines Against Schistosomiasis, Alex Loukas, Jeffrey M. Bethony, Andre´ Capron, and Donald P. McManus

Vaccines Against Entamoeba histolytica, Christopher D. Huston and William A. Petri, Jr.

Hookworm Vaccines, Jeffrey M. Bethony, Maria Elena Bottazzi, Ami Shah Brown, David Diemert, Peter Hotez, and Alex Loukas

Improved Smallpox Vaccines, Matthew E. Cohen and Stuart N. Isaacs

Anthrax Vaccines, Arthur M. Friedlander, Stephen F. Little, and Marc Gurwith

Tularemia Vaccines, Alan S. Cross and Eileen M. Barry

Vaccines Against Plague, Scott A. Lloyd

Development of Vaccines for Ebola and Marburg Viruses: Efficacy and Regulatory Considerations, Gary J. Nabel

Therapeutics and Vaccines Against Hendra and Nipah Viruses, Christopher C. Broder

Vaccines Against Lassa Fever, Maria S. Salvato and Igor S. Lukashevich

Hantavirus Vaccines, Christopher D. Hammerbeck and Jay W. Hooper

SARS Vaccines, Kanta Subbarao

Cancer-Specific Vaccines, Drew Pardoll

Vaccines Against Human Papillomaviruses, Kathrin U. Jansen and Ian H. Frazer

Vaccines Against Alzheimer’s and Other Neurodegenerative Diseases, Roy M. Robins-Browne and Colin L. Masters

Vaccination for Autoimmune and Other Chronic, Inflammatory Disorders, Leonard C. Harrison

Immunotherapies To Treat Drug Addiction., Paul R. Pentel, Dan E. Keyler, and Thomas R. Kosten

Index

Subject Categories

BISAC Subject Codes/Headings:
MED014000
MEDICAL / Clinical Medicine
MED022090
MEDICAL / Infectious Diseases