1st Edition

New Technologies and Perinatal Medicine Prediction and Prevention of Pregnancy Complications

    264 Pages 100 Color & 40 B/W Illustrations
    by CRC Press

    264 Pages 100 Color & 40 B/W Illustrations
    by CRC Press

    The potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a  real look into the future via the newest methodologies.

    List of contributors


    Introduction: Why do we need Omics and Systems Biology
    Joe Leigh Simpson and Moshe Hod

    A Pregnancy Complications: Setting the Scene

    1. The Mother: Adaptation to Pregnancy and normal metabolism

    Irene Cetin, Francesca Parisi, Alice Zavatta, and Roberta Milazzo

    2. Maternal and fetal normal and abnormal nutrition

    Sarah Louise Killeen, Eilleen C O’Brien, and Fionnuala M McAuliffe

    3. The Great Obstetrical Syndromes: It's all in the placenta
    Martin Gauster and Gernot Desoye

    4. Embryo-specific communication and interaction with the maternal environment: The role of PreImplantation Factor
    Eytan R Barnea and Michael Stark

    5. Normal and abnormal fetal growth

    Javier Caradeux, Eduard Gratacos, and Francesc Figueras

    6. Pre-term labor and birth

    Vincenzo Berghella and Eduardo da Fonseca

    7. Gestational Diabetes Mellitus
    Silvia Vannuccini and Federico Mecacci

    8. Pre-eclampsia

    Jon Hyett and Liona Poon

    9. Maternal obesity

    Tahir A. Mahmood and Rohan Chodankar

    10. Maternal health: Immediate, short-, and long-term complications following pregnancy

    Gil Gutvirtz, Omri Zamstein, and Eyal Sheiner

    11. The fetus and the neonate: Immediate, short, and long term impact
    Umberto Simeoni and Elie Saliba

    12. The cost of pregnancy complications related to non-communicable diseases and the cost effectiveness of interventions to address them

    Anil Kapur, Jon Hyett, and H David McIntyre

    B Towards Prediction and Prevention

    13. Integrated System Biology approaches to Fetal Medicine problems

    Jezid Miranda, Fátima Crispi, and Eduard Gratacós

    14. Omics and female reproduction

    Galia Oron

    15. The maternal genome and pregnancy outcomes
    Nagendra K. Monangi, Ge Zhang, Mikko Hallman, Kari Teramo, Bo Jacobsson, and Louis J Muglia

    16. Placental development and Omics

    Sylvie Hauguel-de Mouzon, Gernot Desoye, and Silvija Cvitic

    17. Placental metabolomics in obese pregnancies
    Irene Cetin, Chiara Novielli, and Chiara Mandò

    18. The methylome and epigenetics markers

    Skevi Kyriakou, Marios Ioannides, George Koumbaris, and Philippos Patsalis

    19. The microbiome and pregnancy complications
    Maria Carmen Collado and Omry Koren

    20. Small non-coding RNAs as biomarkers for pregnancy complications
    Liron Yoffe, Meitar Grad, Avital Polsky, Moshe Hod, and Noam Shomron

    21. Urine metabolomics and proteomics in prenatal health

    Daniela Duarte, Maria do Céu Almeida, Pedro Domingues, and Ana M. Gil

    22. The metabolomics and perinatal complications

    Flaminia Bardanzellu, Moshe Hod, and Vassilios Fanos

    23. Metabolomics in normal and pathologic pregnancies

    Antonio Ragusa, Alessandro Svelato, and Sara D’Avino

    24. Metabolomics in amniotic fluid

    Alexandra-Maria Michaelidou, Foteini Tsakoumaki, Maria Fotiou, Charikleia Kyrkou, and Apostolos P. Athanasiadis

    25. Omics and coagulation disorders in pregnancy

    Sara Ornaghi and Michael J Paidas

    26. The omics and preeclampsia
    Piya Chaemsaithong and Liona C. Poon

    27. Single Nucleotide Polymorphisms and pregnancy complications

    Federica Tarquini, Giuliana Coata, Elena Picchiassi, and GianCarlo Di Renzo
    28. Metabolomics and perinatal cardiology

    Roberta Pintus, Angelica Dessì, and Vassilios Fanos

    29. Metabolomics and human breast milk: a unique and inimitable food for infants

    Flamina Cesare Marincola, Sara Corbu, Roberta Pintus, Angelica Dessì, and Vassilios Fanos

    30. Neurodevelopment and placental omics
    Despina D. Briana and Ariadne Malamitsi-Puchner

    31. Early life complications, placental genomics, and the risk for neurodevelopmental disorders in the offspring

    Pasquale Di Carlo, Giovanna Punzi, and Gianluca Ursini

    32. Metabolomics and perinatal asphyxia

    Ernesto d’Aloja, Emanuela Locci, Antonio Noto, Matteo Nioi, Giovanni Bazzano, and Vassilios Fanos

    33. Environment, pregnancy complications, and omics

    Chen Ben David and Ido Solt

    34. Sleep and pregnancy complications

    Orna Sever and Riva Tauman

    35. Maternal plasma cell-free DNA screening: I. Basic science and applications
    Peter Benn and Howard Cuckle

    36. Maternal plasma cell-free DNA screening: II. Integration into clinical practice

    Howard Cuckle and Peter Benn

    37. Microarrays

    Melissa Stosic, Jessica L. Giordano, Brynn Levy, and Ronald Wapner

    38. Whole exome and whole genome sequencing
    Mary E. Norton



    Prof. Moshe Hod is Director of the Mor Comprehensive Women's Health Care Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel, President of the European Association of Perinatal Medicine, and Chairman of the FIGO  Hyperglycemia in Pregnancy Working Group. Eduard Gratacos is Head and Professor of Maternal-Fetal Medicine at Hospitals Clínic de Barcelona & Sant Joan de Déu, Barcelona, Spain. Vincenzo Berghella is Professor and Director, Division of Maternal-Fetal Medicine at Thomas Jefferson University, Philadelphia, PA, USA, and President of the Society for Maternal-Fetal Medicine. Mary E D'Alton is Willard C. Rappleye Professor of Obstetrics & Gynecology and Director of Services, Sloane Hospital for Women, and Chair of the Department of Obstetrics & Gynecology, Maternal-Fetal Medicine, Columbia University Medical Center, New York, NY, USA, and is a past president of the Society for Maternal-Fetal Medicine. Prof. Gian Carlo Di Rezo is Director of Perinatal and Reproductive Medicine Center and Midwifery School, University Hospital Perugia, Italy and Director of Permanent International and European School of Perinatal and Reproductive Medicine, Florence, Italy. Prof. Vassilios Fanos is Professor of Pediatrics and Director of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy.