New Therapeutic Agents in Thrombosis and Thrombolysis: 3rd Edition (Hardback) book cover

New Therapeutic Agents in Thrombosis and Thrombolysis

3rd Edition

Edited by Jane E. Freedman, Joseph Loscalzo

CRC Press

712 pages | 32 Color Illus. | 108 B/W Illus.

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Hardback: 9781420069235
pub: 2009-06-24
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eBook (VitalSource) : 9780429149702
pub: 2016-04-19
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As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for treating cardiovascular and thromboembolic diseases.

New to the Third Edition:

  • a thorough examination of all the agents involved in treating thrombosis
  • chapters on biomarkers, testing, and pharmacogenomics
  • key topics, including new targets for antithrombotics, the development of novel classes of platelet inhibitors, new thrombolytic therapies, and evolving clinical uses of thrombolytics for ischemic stroke and venous thrombosis
  • the hemostatic and thrombotic pathways


"…Full of important information… is a definite addition to the medical literature." —Doody’s Reviews (for the Second Edition)

Table of Contents


Jane EFreedman

Overview of Hemostasis and Fibrinolysis, Andrew ISchafer

Overview of Platelet-Dependent Thrombosis, Jane EFreedman, Price Blair, and Joseph Loscalzo

Design Issues in Clinical Trials of Thrombolytic and Antithrombotic Agents, Robert PGiugliano

Pharmacogenomics and Warfarin Anticoagulation, Melkon Hacobian and Samuel ZGoldhaber

Pharmacogenomics of Platelet Inhibitors, Srikanth Nagalla, Suzanne MLeal, and Paul FBray

The Effects of Antiplatelet, Antithrombotic, and Thrombolytic Agents on Inflammation and Circulating Inflammatory Biomarkers, Erdal Cavusoglu

The Role of Platelet Function Testing in the Development of Platelet Inhibitors, Alan DMichelson

The Role of Proteomics and Transcriptomics in the Development of Antithrombotics, Lisa Senzel, Dmitri VGnatenko, and Wadie FBahou


Jeffrey IWeitz

Overview of New Anticoagulant Drugs, Nahid Qushmaq and Jeffrey IWeitz

Anticoagulants for the Treatment of Venous Thromboembolism, Sam Schulman

Anticoagulation in Acute Coronary Syndromes, Simon JMcRae and John WEikelboom

Anticoagulation in Pregnancy, Shannon MBates

Anticoagulants in Cancer, Edward NLibby and Agnes YLee

Anticoagulation in Children, Paul TMonagle and Anthony K.CChan

New Heparins: Synthetic Pentasaccharides, Pieter WKamphuisen and Harry RBüller

Treatment of Heparin-Induced Thrombocytopenia, Theodore EWarkentin

Emerging Links Between Thrombosis, Inflammation, and Angiogenesis: Key Role of Heparin and Low-Molecular-Weight Heparins, Shaker AMousa

Oral Direct Factor Xa Inhibitors, Alexander GGTurpie

Direct Thrombin Inhibitors, Menaka Pai and Mark ACrowther

Modulators of the Protein C Pathway, Charles TEsmon

Factor IXa Inhibitors, Richard CBecker, Mark Chan, Emily LHoward, Kristian CDBecker, and Christopher PRusconi

Contact-Activation Pathways as Targets for New Anticoagulants, David Gailani, Thomas Renne´, and Andras Gruber


Robert PGiugliano

Overview of Antiplatelet Therapy, Shaker AMousa, James TWillerson, and Robert PGiugliano

Markers of Platelet Function, Udaya STantry and Paul AGurbel

Intravenous Glycoprotein IIb/IIIa Antagonists, Jason NKatz and Robert AHarrington

Inhibitors of Platelet Adhesion: VWF-GPb/IX and Collagen-GPVI

Inhibitors, Robert GSchaub

Three Generations of Thienopyridines: Ticlopidine, Clopidogrel, and Prasugrel, Stephen DWiviott and Elliott MAntman

Direct PYAntagonists, Marco Cattaneo

Nitric Oxide Donors as Platelet Inhibitors, Lina Badimon and Gemma Vilahur

The Interrelationship of Thrombin and Platelets—The Protease-Activated Receptor-, Rohit Bhatheja and David JMoliterno

Other Antiplatelet Agents, Catherine McGorrian and Sonia SAnand

The Combination of Anticoagulants and Platelet Inhibitors Postcoronary Stent Implantation, Hussam Hamdalla and Steven RSteinhubl


HRoger Lijnen

Overview of Established and New Thrombolytics, HRoger Lijnen

Thrombolysis of Deep Vein Thrombosis, Peter Verhamme, Raymond Verhaeghe, and Geert Maleux

Thrombolysis for Acute Pulmonary Embolism, Gregory Piazza and Samuel ZGoldhaber

Acute Thrombolysis in Ischemic Cerebrovascular Disease, Gregory Jdel Zoppo

Fibrinolysis for Acute Myocardial Infarction, Cheuk-Kit Wong and Harvey DWhite

Epilogue: The Evolution of Therapeutic Management of Thrombotic and Cardiovascular Disease, Jane EFreedman and Joseph Loscalzo


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Cardiology
MEDICAL / Hematology
MEDICAL / Pharmacology