1st Edition

New and Exploratory Therapeutic Agents for Asthma




ISBN 9780367399252
Published September 5, 2019 by CRC Press
528 Pages

USD $74.95

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Book Description

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches!
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma

  • explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
  • examines the role of monoclonal antibodies in allergy and asthma
  • describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
  • investigates the controversy of different types of asthma
  • illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
  • assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
  • reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
  • evaluates the relationship between improvements in laboratory results and clinical effectiveness
  • and more!
    Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical s

  • Table of Contents

    Epidemiology of Asthma
    Stephen T. Holgate and A. N. Banik
    Pathophysiology of Asthma
    Peter J. Sterk
    Pathology of Asthma
    Ratko Djukanoviâ
    Muscarinic Receptor Subtypes and Anticholinergic Therapy
    Allison D. Fryer, Richard W. Costello, and David B. Jacoby
    Long-Acting 2-Agonist Drugs
    Richard Beasley, Julian Crane, and Carl Burgess
    Inhaled Glucocorticoids, Established and New
    Joseph D. Spahn and Stanley J. Szefler
    Platelet-Activating Factor Antagonists in Bronchial Asthma
    Devendra K. Agrawal and Robert G. Townley
    Tachykinin Receptor Antagonists
    Guy F. Joos and Charles Advenier
    Therapeutic Potential of Phosphodiesterase Type 4 Inhibitors in the Treatment of Asthma
    Bernadette Hughes and Gerry Higgs
    Leukotriene Modulators
    Anthony P. Sampson and Zuzana Diamant
    The Anti-IgE Treatment Strategy for Asthma
    John V. Fahy
    Activity of T-Cell Subsets in Allergic Asthma
    André Boonstra and Huub F. J. Savelkoul
    New Targets for Future Asthma Therapy
    Peter J. Barnes
    Current Practice and Future Trends in Clinical Trials in Asthma
    Johan C. Kips and Romain A. Pauwels

    ...
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    Author(s)

    Biography

    Yeadon, Michael; Diamant, Zuzana