Next-Gen Therapies for Metabolic and Endocrine Disorders Beyond Conventional Approaches

Foreword by Dr. Gaurav Gupta

Foreword by Dr. Anurag Kuhad

Preface

1. Novel Therapeutic Approaches to Metabolic Syndrome

Selin C. Joy, Unnikrishnan M. K., Prashant Chandra, Govind K. Pradeep, Sivakami Premjith, Muhammed Shafi P. A., Bilha Baby, Anjaly Venugopal, and Keshav Raj Paudel

2. Novel Strategies for Thyroid Disorders: Beyond Hormones

Nitish Bhatia and Benu George

3. Therapeutic Approach of Single-Cell Transcriptomics: Emergence in Metabolic and Endocrine Disorders

Neha Kukreti, Shilpa Rana, Thakur Gurjeet Singh, Diksha Sharma, Gabriele De Rubis, and Sanjana Mehta

4. Therapeutic Approaches to Newer Classes of Drugs and Treatments for Type 2 Diabetes Mellitus

Abhik Paul, Sai Satyaprakash Mishra, Sourin Nahar, Avik Maji, Tapas Kumar Bhowmick, Tapan Kumar Maity, and Venkata Sita Rama Raju Allam

5. Recent Applications of Artificial Intelligence and the Internet of Things in Diagnosis and Management of Diabetes Mellitus

Ling Dai, Mengli Kang, Lili Liu, and Haipeng Liu

6. Investigation of Anti-Hyperlipidemic Activity of Trapa bispinosa Fruit Peel Extract on HFD-Induced Mice Model

Kumar Anand, Sayak Khawas, Mahendra Pratap Chopra, Neelima Sharma, and Brian G. Oliver

7. Metabolic Crisis: Phenylketonuria

Deepti M. Sati, Neha Chauhan, Deepika Raina, Lovleen Kaur, Sanjana Mehta, and Thakur Gurjeet Singh

8. Diabetic Gastroparesis: Current Trends in Management

Nidhi Garg, Henaroop Tiwana, Sarita Jangra, Shaima K. A., Poonam Maurya, Sanjana Mehta, and Thakur Gurjeet Singh

9. Management of Complications Arising from Cerebrovascular Events with Pharmaceutical Interventions

Naina Dubey, Sampat Singh Tanwar, Neelima Goswami, Ramandeep Singh, Seema Sharma, and Sanjeev Sharma

10. Relevant Therapeutic Approaches to Chronic Renal Failure

Rupinder Kaur, Rajwinder Kaur, Amrit Kaur, Iresha, Ujjwal Kaushik, Ravinder Singh, Balakumar Chandrasekaran, Thakur Gurjeet Singh, and Sanjana Mehta

11. Unraveling the Metabolic Complexities of Gaucher's Disease and Its Correlation with Parkinson's Disease

Prachi Mall, Deepika Raina, Sona Kakkar, Pranjal Garg, Karabi Kalita, and Nitin Chitranshi

12. A Brief Review on the Role of Various Molecular Targets and Pharmacological Strategies for Diabetic Wound Healing

Amrita Das, Nibir Ghosh, Sangita Palai, Gourab Dey, Laiba Parveen, and Terezinha De Jesus Andreoli Pinto

13. Epigenetic Modifications and Metabolic Health

Seema Sharma, Sampat Singh Tanwar, Sneha Kumari, Naina Dubey, and Amit Khurana

14. The Major Pathways and Treatment Approaches Involved in Adrenal Metabolic Disorders

Himanshu Sharma, Praveen Halagali, Devika Nayak, Vamshi Krishna Tippavajhala, Rashmi Pathak, and Srinivas Nammi

15. Exploring Nutritional Strategies for Polycystic Ovary Syndrome Management

Deepika Raina, Prachi Mall, Stuti Goyal, Karabi Kalita, Loveleen Kaur, Flavia C. Zacconi, Thakur Gurjeet Singh, and Sanjana Mehta

16. Prenatal Stress and Risk Factors for Metabolic Disease: The Mediating Role of DNA Methylation

Sampat Singh Tanwar, Seema Sharma, Manali Parkhi, Ramandeep Singh, Naina Dubey, and Sheema Khan

17. Pharmacotherapeutic Potential and Clinical Efficacy of Microbiota in Metabolic Disorders

Satnam Singh, Amandeep Kaur, Thakur Gurjeet Singh, Sanjana Mehta, Ashi Mannan, Divya Kanwar, Bhavesh Dharmani, and Sofia Kokkinis

Biography

Thakur Gurjeet Singh, PhD, MPharm, has 16 years of experience in industry, research, and teaching. He is working as Dean, Chitkara College of Pharmacy, Chitkara University, Punjab, India. He is engaged with projects on interception of nicotine, morphine, alcohol dependence, ischemia, diabetic neuropathy and nephropathy toxicology, epilepsy, Alzheimer disease, and stem cell research studies and handles affiliation formalities with the director office. He has attended UGC networking courses and various preclinical and clinical research training programs. He has more than 182 research publications (many Scopus-indexed) as well as 25 book chapters, eight books, and 58 filed patents to his name. He has attended more than 60 national and international conferences. He has guided theses for 65 MPharm students and is supervising 10 PhD candidates. He is a reviewer for several international journals. He is a member secretary of the Committee for the Purpose of Control and Supervision of Experiments on Animals and is the In-Charge of the animal house facility at Chitkara College of Pharmacy. He is also a member secretary for institutional human ethical committee registered with the Department of Health Research and CDSCO New Delhi, India.

Sanjana Mehta, PhD, is working as an Assistant Professor and the Coordinator of the Institutional Innovation Cell (IIC) at Chitkara College of Pharmacy, Chitkara University, Punjab, India. With five years of academic experience, Dr. Mehta is proficient in clinical studies and medical statistics. Her research interest revolves around advanced pharmacotherapeutic approaches toward metabolic disorders. To date, she has mentored four PharmD students and is currently supervising four PharmD, two MPharm, and one PhD candidate. Dr. Mehta is actively involved in the CancerScreen project, a collaborative venture funded by DST, NewGen IEDC, and Chitkara University, Punjab. Her team has obtained one patent, and she also has a registered copyright to her credit. She has various published patents to her credit. She has also been honored with the Best PhD Award and Award of Honor at the National Pharma Tech & Youth Fest 2023 and 2024. Her academic background includes a PharmD and a PhD in Pharmaceutical Sciences.

“This ground-breaking work represents a significant milestone in our quest to understand and treat metabolic and endocrine disorders more effectively. . . . A comprehensive and forward-thinking resource that delves into the most promising advancements in the field. From gene therapy and stem cell therapy to precision medicine and digital health technologies, this book explores the cutting-edge treatments that are set to redefine how we approach these complex disorders. . . . An invaluable resource, offering up-to-date perspectives on the latest research findings and future directions in the treatment of metabolic and endocrine disorders.”

—From the Foreword by Dr. Gaurav Gupta, Adjunct Research Professor, Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates  

“A remarkable book that stands at the forefront of a rapidly evolving field, offering innovative perspectives and cutting-edge solutions to some of the most challenging metabolic and endocrine disorders of our time. . . . Explore[s] groundbreaking therapies that go beyond conventional approaches, addressing the complexities of these disorders with novel strategies and technologies. . . The authors not only discuss the current state of next-gen therapies but also envision future directions and innovations that could further transform the landscape of metabolic and endocrine disorder management. This holistic perspective is invaluable for clinicians, researchers, and students seeking to stay ahead in a field that is continually evolving. An essential reference, guiding healthcare professionals towards more effective, personalized, and innovative treatments.”

—From the Foreword by Dr. Anurag Kuhad, Assistant Professor, University Institute of Pharmaceutical Sciences, Punjab University, India