Nucleoside Analogs in Cancer Therapy: 1st Edition (Hardback) book cover

Nucleoside Analogs in Cancer Therapy

1st Edition

Edited by Bruce D. Cheson, Michael J. Keating, William Plunkett

CRC Press

488 pages

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Hardback: 9780824798505
pub: 1997-05-09
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Offering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell leukemia, non-Hodgkin's lymphoma, membranous nephropathy, and rheumatoid and psoriatic arthritis.



…this volume is the first overview summarising the state of the art of purine analogs. The editors were able to get excellent papers together…recommend[ed] to all haemato-oncologists who treat patients with purine analogs.

"-Annals of Oncology

Table of Contents

Nucleoside Analogs: Cellular Pharmacology, Mechanisms of Action, and Strategies for Combination Therapy, William Plunkett and Varsha Gandhi

Induction of Apoptosis by Nucleoside Analogs, Peng Huang and Susan Wright

Pharmacokinetics of Purine Nucleoside Analogs, Jan Liliemark and Gunnar Juliusson

Clinical Development of 2'-Deoxycoformycin, Bruce D. Cheson and Michael R. Grever

Clinical Development of Fludarabine, Axel-R. Hanauske and Daniel D. Von Hoff

Development of 2-Chlorodeoxyadenosine (2-CdA) as a Chemotherapeutic and Immunosuppressive Drug, Ernest Beutler, Dennis Carson, Robert McMillan, and Robert Longmire

Defining the Optimal Dose Schedule of Purine Analogs and Assessment of Response, Jorge E. Cortes and Susan M. O'Brien

Clinical Trials of the Purine Analogs in Chronic Lymphocytic Leukemia, Michael J. Keating

Treatment of Hairy Cell Leukemia with Nucleoside Analogs, Alan Saven and Lawrence D. Piro

Clinical Trials with Nucleoside Analogs in Lymphomas, Wolfgang Hiddemann and Christiane Pott-Hoeck

Clinical Trials with Nucleoside Analogs in Other Hematologic Malignancies, Jorge E. Cortes, Hagop Kantarjian, Susan M. O'Brien, and Michael J. Keating

Nucleoside Analogs as Radiosensitizing Agents, Vincent Grégoire and Walter N. Hittelman

2-Chlorodeoxyadenosine in Nonmalignant Disorders, Ernest Beutler, Dennis Carson, J. C. Sipe, J. S. Romine, Robert McMillan, Z. M. Younossi, V. D. Rodgers, James A. Koziol, and J. Zyroff

Fludarabine in Nonmalignant Disorders, Ioannis O. Tassiulas, John C. Davis, Jr., Barri J. Fessler, Nobuaki Hama, Thomas A. Fleisher, Howard A. Austin III, and Dimitrios T. Boumpas

Toxicities Associated with Purine Analog Therapy, Bruce D. Cheson

About the Series

Basic and Clinical Oncology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Hematology
MEDICAL / Oncology