Nutrition and Gene Expression is devoted to exploring the tissue-specific and developmental aspects of the interaction between nutrients and the genome. The book discusses chemical sensitivity in relation to the ability of cells to detect nutrients; reviews the means by which lower organisms respond to nutrients; and provides examples on how each of the classes of nutrients affects genetic transcription, mRNA translation or stability. The receptor-mediated actions of vitamin D and retinoic acid on gene expression are discussed, including the case of bone formation and dissolution. Other important topics covered in the volume include newly discovered effects of fatty acids on regulating gene expression, the effects of diet on mRNA editing, the interplay between dietary carbohydrates and proteins in regulating metabolism of liver cells, the effects of metal ions on protein synthesis, and much more.
Nutrition and Gene Expression is an important reference for nutritionists, physiologists, biochemists, clinical nutritionists, pharmaceutical researchers, geneticists, and food scientists.
Table of Contents
1.Nutrient Receptors and Gene Expression 2.Lactose Intolerance and Regulation of Small Intestinal Lactase Activity 3. Regulation of Gastrointestinal Lipase Gene Expression by Dietary 4. Nutritional Control of Gastrointestinal Hormone Gene Expression 5.Calcium Homeostasis, Endoplasmic Reticular Function, and the Regulation of mRNA Translation in Mammalian Cells 6.Tissue-Specific Regulation of Glucokinase 7. Dietary and Hormonal Regulation of L-Type Pyruvate Kinase Gene Expression 8. Glucose-6-Phosphate Dehydrogenase: Diet and Hormonal Influences on De Novo Enzyme Synthesis 9. Nutritional and Hormonal Regulation of Genes Encoding Enzymes Involved in Fat Synthesis 10. Regulation of Hepatic Gene Expression by Dietary Fats: A Unique Role for Polyunsaturated Fatty Acids 11. Dietary Fat, Gene Expression, and Carcinogenesis 12. Regulation of Acetyl CoA Carboxylase and Gene Expression 13. Apolipoprotein B mRNA Editing 14. Regulation of the 68 kDa Hepatic Carnitine Palmitoyltransferase 15. Long-Term Regulation of Hepatic Glutaminase and the Urea Cycle Enzymes 16. Effects of Dietary Protein on Gene Expression 17. Vitamin D-Dependent Calcium Binding Protein, Calbindin-D: Regulation of Gene Expression 18. Vitamin D Regulation of Osteoblast Growth and Differentiation 19. Retinoic Acid Regulation of Gene Expression in Adipocytes 20. The Role of Vitamin K in Clotting Factor Biosynthesis 21. Role of Ascorbate in Regulating the Collagen Pathway 22. Dietary Regulation of Metallothionein Expression 23. Iron-Dependent Regulation of Ferritin Synthesis 24. Vitamin B6 Modulation of Steroid Induced Gene Expressio