1st Edition

Nutritional Genomics The Impact of Dietary Regulation of Gene Function on Human Disease

Edited By Wayne R. Bidlack, Raymond L. Rodriguez Copyright 2012
    448 Pages 114 B/W Illustrations
    by CRC Press

    The notion of matching diet with an individual’s genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health.

    Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics—including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system.

    Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

    Epigenetics: The Epigenetic Transfer of Phenotype
    Epigenetics: Molecular Targets for Diet and Cancer Prevention, Sharon A. Ross
    Diet-influenced Chromatin Modification and Expression of Chemopreventive Genes by the Soy Peptide, Lunasin, Alfredo F. Galvez, Liping Huang, Mark J.M. Magbanua, Kevin Dawson, Somen Nandi and Raymond L. Rodriguez
    Role of Epigenetics in the Complications Associated with Diabetes and Related Metabolic Disorders, Louisa M. Villevenuve and Rama Natarajan
    Systems Biology: Cell Signaling Regulation of Gene Expression
    Systems Biology Approaches to Study Diet x Genome Interactions, Xia Yang, Zhidong Tu and Jun Zhu
    Modulation of Atherosclerosis by N-3 Polyunsaturated Fatty Acids, Darshan S. Kelley, Yuriko Adkins, Sumeet Sharma, Dawn M. Fedor
    Nutrigenomic Implications for Nuclear Receptor Coactivators, David M. Lonard and Bert W. O’Malley
    Nutrigenomics of Fatty Acid Sensing, Sander Kersten
    The Polyphenol Resveratrol Alters Global Patterns of Gene Regulation and Improves Physiology Through Multiple Potential Pathways, Behzad Varamini and Joseph A. Baur
    Nutritional Genomics: Cellular Signaling and Molecular Targets, Wayne R. Bidlack
    Gene Linked Chronic Disease
    Mechanisms Mediating Obesity-Induced Inflammation and Insulin Resistance, Simon Schenk, Olivia Osborn and Jerrold M. Olefsky
    Nutritional Genomics of Vitamin D on Cardiovascular Disease, Sandra F. Williams, Jorge N. Artaza and Keith C. Norris
    Gene Linked Cancer Prevention
    Network Analysis of Gene Expression Profiles in Breast Cancer Cell Lines, T. Gregory Dewey, Katie L. Streicher and Stephen P. Ethier
    Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention, Ann M. Bode and Zigang Dong
    Green Tea Polyphenols, DNA Repair and Prevention of Photocarcinogenesis, Santosh K. Katiyar
    Bioactive Food Components and the "U" Shaped Health Conundrum: Vitamin D and Folate as Examples of Friends and Foes, John A. Milner
    Intestinal Microbiome Linked Gene Expression
    Human Intestinal Microbiome: Etiology of Inflammation Genomics, Roger A. Clemens
    Agriculture’s Ability to Enhance Food Quality
    Calcium Biofortification of Crops, Kendal D. Hirschi and Sean M. Thompson
    The Use of Genomics-Aided Breeding to Improve the Nutritional Content of Lettuce, David W. Still
    Food Science and Technology Enhancement of Diet quality
    Natural Colorants as Bioactive Agents in Functional Foods, Ann Marie Craig
    Manufacturing Functional Foods: Effects on Quality and Bioavailability, Ryan J. Elijas and John D. Floros
    New Whole Foods Designed to Deliver Bioactive Components, Cheryl Mitchell
    Regulatory Oversight
    Nutritional Genomics and the Future of Food Labeling in the US, Evelyn D. Cadman


    Dr. Bidlack received his Bachelor of Science degree in Dairy Science and Technology from the Pennsylvania State University (1966), his Master of Science degree in Food Science from Iowa State University (1968), and his Ph.D. Degree in Biochemistry from the University of California, Davis (1972). In addition, he was a postdoctoral fellow in Pharmacology at USC School of Medicine (1972-1974).