1st Edition
Ocular Drug Delivery Systems Barriers and Application of Nanoparticulate Systems
Basic Considerations
Nanoparticle-Based Therapeutics: An Overview
Deepak Thassu, Kris Holt, and Gerald J. Chader
Eye Anatomy, Physiology and Ocular Barriers: Basic Considerations for Drug Delivery
Gerald J. Chader and Deepak Thassu
Animal Models to Evaluate Ocular Nanoparticular Drug Delivery Systems
Vinson M. Wang, Jingsheng Tuo, and Chi-Chao Chan
Computer Modeling for Ocular Drug Delivery
Paul J. Missel
Challenges in the Development of Nanotechnology-Based Ophthalmic Systems
Banu S. Zolnik, Sheriza Baksh, and Nakissa Sadrieh
Ocular Barriers
Blood–Retinal Barrier: The Fundamentals
Rosa Fernandes, Andreia Gonçalves, and José Cunha-Vaz
Barriers to Transscleral Drug Delivery to the Retina
Alexandra Almazan, Susan S. Lee, Aron D. Ross, and Michael R. Robinson
Ocular Compartment Drug Delivery
Drug Delivery to the Vitreous Humor
Francine Behar-Cohen
Transscleral and Suprachoroidal Drug Delivery
Damian E. Berezovsky and Henry F. Edelhauser
Protein Drug Delivery to Retina and Choroid
Hongwen M. Rivers and Patrick M. Hughes
Transscleral Drug Delivery to the Posterior Segment of the Eye
Bernard F. Godley, Cheryl L. Rowe-Rendleman, Ed Kraft, and Gabriella Kulp
Drug Delivery to the Suprachoroidal Space
Sung Won Cho and Timothy W. Olsen
Use of Nanoparticles in the Treatment of Age-Related Macular Degeneration, Glaucoma, and Other Degenerative Retinal Diseases
Marco A. Zarbin, Carlo Montemagno, James F. Leary, and Robert Ritch
Drug Delivery Systems
Drug Molecule Characteristics, Drug Delivery Strategies and Their Impact on Ophthalmic Drug Delivery to Anterior versus Posterior Segments
Kay D. Rittenhouse
Surface Modulation of Nanoparticles
Deepak Thassu and Kris Holt
Nanoparticles for the Treatment of Retinal Diseases
Amin Famili and Uday B. Kompella
Gene-Based Medicine for Ocular Diseases
Shannon M. Conley and Muna I. Naash
Stealth-Type Polymeric Nanoparticles with Encapsulated Betamethasone Phosphate for Treatment of Intraocular Inflammation
Tsutomu Sakai, Tsutomu Ishihara, and Megumu Higaki
Technology and Materials Development
Nanotechnology-Guided Imaging of Retinal Vascular Disease
Joshua R. Trantum and Ashwath Jayagopal
Photoresponsive Polymers for Ocular Drug Delivery
Laura A. Wells and Heather Sheardown
Nanosuspensions in Ocular Drug Delivery Systems
Himanshu Bhattacharjee and Sonia Bedi
Biography
Deepak Thassu is the Vice President of Pharmaceutical Development at Pharmanova, Inc., in Victor, New York.
Gerald Chader is Chief Scientific Officer of the Doheny Retina Institute at USC Medical School in Los Angeles.
