1st Edition
Omega-3 Fatty Acids and the DHA Principle
Introduction
Molecular Biology of Omega-3 Chains as Structural Lipids:
Many Central Questions Remain Unanswered
Evolution of DHA and the Membrane
Darwinian Selection of the Fittest Membrane Lipids: From Archaeal Isoprenoids to DHA-Enriched Rhodopsin Disks
Coevolution of DHA Membranes and Their Proteins
Convergent Evolution of DHA/EPA Biosynthetic Pathways
Membrane Evolution in a Marine Bacterium: Capitalizing on DHA for Energy Conservation in Seawater
Evolution of DHA Membranes in Human Neurons
General Properties of Omega-3s and Other Membrane Lipids
DHA/EPA Chains as Powerful Membrane Antifreeze
DHA as a Mediocre Permeability Barrier against Cations: Water Wire Theory
DHA/EPA Membranes as Targets of Oxidative Damage
Cellular Biology of Omega-3s and Other Membrane Lipids
Bacteria: Environmental Modulation of Membrane Lipids for Bioenergetic Gain
Chloroplasts: Harnessing DHA/EPA for Harvesting Light in the Sea
Mitochondria: DHA-Cardiolipin Boosts Energy Output
Sperm: Essential Roles of DHA Lead to Development of a Mechanical Stress Hypothesis
Lessons and Applications
DHA/EPA Mutualism between Bacteria and Marine Animals
Membrane Adaptations for an Oily Environment: Lessons from a Petroleum-Degrading Bacterium
Lessons from Yeast: Phospholipid Conformations Are Important in Winemaking
DHA Principle Applied to Global Warming
DHA Principle Applied to Molecular Farming
DHA/Unsaturation Theory of Aging
DHA Principle Applied to Neurodegenerative Diseases
Dietary DHA in Prevention of Colon Cancer: How a Risk to the Cell Benefits the Organism
Index
Biography
Raymond C. Valentine is Professor Emeritus at the University of California, Davis and Visiting Scholar in the Marine Science Institute at the University of California in Santa Barbara. David L. Valentine is an associate professor of earth science at the University of California in Santa Barbara.
