1st Edition
Omics in Clinical Practice Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research
Introduction
Part 1: Omics and Human Disease
Comparative Mitochondrial Proteomics: Perspective in Human Diseases; Yujie Jiang and Xin Wang
Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches; Elena Silvestri, Assunta Lombardi, Pieter de Lange, Daniela Glinni, Rosalba Senese, Federica Cioffi, Antonia Lanni, Fernando Goglia, and Maria Moreno
Next Generation Sequencing in Cancer Research and Clinical Application; Derek Shyr and Qi Liu
Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice; Y. W. Francis Lam
Part 2: Translational and Personalized Medicine
Clinical Proteomics and Omics Clues Useful in Translational Medicine Research; Elena López, Luis Madero, Juan López-Pascual, and Martin Latterich
Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data; David Toomey, Heinrich C. Hoppe, Marian P. Brennan, Kevin B. Nolan, and Anthony J. Chubb
Part 3: Molecular and Genetic Markers
Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine; Elisabeth Drucker and Kurt Krapfenbauer
How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles and Automated Microscopic Image Analyses for Clinical Needs and Public Health; Vladimir Kuznetsov, Hwee Kuan Lee, Sebastian Maurer-Stroh, Maria Judit Molnár, Sandor Pongor, Birgit Eisenhaber, and Frank Eisenhaber
Application of "Omics" to Prion Biomarker Discovery; Rhiannon L. C. H. Huzarewich, Christine G. Siemens, and Stephanie A. Booth
Part 4: Omics and Pathogens
Insights from Genomics into Bacterial Pathogen Populations; Daniel J. Wilson
High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach; Gilbert Greub, Carole Kebbi-Beghdadi, Claire Bertelli, François Collyn, Beat M. Riederer, Camille Yersin, Antony Croxatto, and Didier Raoult
Coronavirus Genomics and Bioinformatics Analysis; Patrick C. Y. Woo, Yi Huang, Susanna K. P. Lau, and Kwok-Yung Yuen
Part 5: Companion Diagnostics
Applications of Next-Generation Sequencing Technologies to Diagnostic Virology; Luisa Barzon, Enrico Lavezzo, Valentina Militello, Stefano Toppo, and Giorgio Palù
Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture; Debasish Paul, Avinash Kumar, Akshada Gajbhiye, Manas K. Santra, and Rapole Srikanth
Index
Biography
Dr. Yu Liu is a bioinformatician with special interest in next-gen sequencing and its applications. His specialties are molecular biology, DNA sequence analysis, next-gen sequencing application on gene expression analysis and comparative genomics, and microarray gene expression analysis. He is the director of the Bioinformatics Resource Center at the University of Wisconsin-Madison. He has a master's degree in computer science from the University of Wisconsin-Madison; a master's degree in developmental biology from the Chinese Academy of Science; and PhD in molecular biology from The Ohio State University.
