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Origin and Evolution of Telomeres book cover

1st Edition

Origin and Evolution of Telomeres

By Jozef Nosek, Lubomir Tomaska Copyright 2008
194 Pages 38 B/W Illustrations
by CRC Press

194 Pages
by CRC Press
Also available as eBook on:
Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes. Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller in 1938. Telomeres are specialized structures that... Read more
Preface 1. Telomerase: Evolution, Structure and Function 2. Drosophila Telomeres: A Variation on the Telomerase Theme 3. Alternative Lengthening of Telomeres in Mammalian Cells 4. T-Loops, T -Circles and Slippery Forks 5. Molecular Diversity of Telomeric Sequences 6. Evolution of Telomere Binding Proteins 7. Telomeres: Guardians of Genomic Integrity or Double Agents of Evolution 8. Evolution, Composition and Interrelated Functions of Telomeres and Sub telomeres: Lessons from Plants 9. Telomere Position Effect and the Evolution of the Genome 10. Cancer as a Micro evolutionary Process Affecting Telomere Structure and Dynamics: The Contribution of Telomeres to Cancer 11. Prokaryotic Telomeres: Replication Mechanisms and Evolution 12. Mitochondrial Telomeres: An Evolutionary Paradigm for the Emergence of Telomeric Structures and Their Replication Strategies

Biography

Jozef Nosek PhD, DSc is an Associate Professor at the Department of Biochemistry, Faculty of Natural Sciences at Comenius University in Bratislava, Slovakia. His research interests include biology and evolution of telomeres, replication of linear mitochondrial genomes and function of their terminal structures, biogenesis of organelles, and morphogenesis of eukaryotic cells. Lubomir Tomaska, PhD, DSc, is an Associate Professor at the Department of Genetics, Faculty of Natural Sciences at Comenius University in Bratislava, Slovakia. He is interested in nucleo-protein structure of nuclear and mitochondrial telomeres, evolutionary pathways leading to different means of telomere maintenance, mitochondrial morphogenesis and inheritance and interplay between the compartments of eukaryotic cells.

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