Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be better understood.
In recent years, research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles is gaining greater appreciation. Ovarian Toxicology, Second Edition represents a compilation of chapters prepared by researchers who have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. The second edition substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition.
- Ovarian physiology and the metabolism of xenobiotics
- The effect of pesticides, heavy metals, phthalates, BPA, and cigarette smoking on the ovaries
- Ovarian cancer, including endocrine effects and new perspectives on chemoresistance
- Epidemiology and human health risk assessment for environmental chemicals and pharmaceuticals
The first book to focus specifically on ovarian toxicology, this resource is ideal for scientists in academia, regulatory agencies, and industry who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.
Table of Contents
Ovarian Physiology; Janice M. Bahr and Krista M. Milich
Ovarian Metabolism of Xenobiotics; S. Ganesan, J.A. Madden, and Aileen F. Keating
Brain as a Target for Environmental Toxicants That Alter Ovarian Function; Ralph L. Cooper and Jerome M. Goldman
Xenobiotic-Induced Oxidative Stress; Ulrike Luderer
Ovotoxicity in Small Preantral Follicles; Patricia B. Hoyer and Connie J. Mark-Kappeler
Ovotoxic Chemical Classes
Ovarian Toxicity Caused by Pesticides; Wei Wang, Patrick Hannon, and Jodi A. Flaws
Endocrine Disruptors; Katherine F. Roby
Phthalates; Timothy P. DelValle, Katlyn S. Hafner, and Zelieann R. Craig
Heavy Metals and the Ovary; Sakhila K. Banu
Cigarette Smoking and Ovarian Function; Anne M. Gannon, J.C. Sadeu, S.K. Agarwal, Claude L.
Hughes, and Warren G. Foster
Bisphenol A and the Ovary; Ronit Machtinger and Catherine Racowsky
Endocrine Effects on Ovarian Cancer; Kendra Hodgkinson and Barbara C. Vanderhyden
New Perspectives in Chemoresistant Ovarian Cancer; Ahmed Y. Ali, Lee Farrand, Ji Young Kim, Akechai Im-Aram, Sanguine Byun, Elaine Lai-Han Leung, Hyong Joo Lee, and Benjamin K. Tsang
Ovarian Cancer; Kathryn Coe, Lisa M. Hess, and G. Marie Swanson
Assessing Ovarian Toxicity in Human Health Risk Assessment for Environmental Chemicals and Pharmaceuticals; Susan L. Makris and Wafa Harrouk
Patricia B. Hoyer, Ph.D., is a professor in the Department of Physiology at the University of Arizona, Tucson. Her research specializes in the effects of environmental chemicals on ovarian function. Her professional activities have included membership in professional societies such as the Society of Toxicology and the Society for Study of Reproduction. She has also served as a panel member and chair for NIH and American Cancer Society study sections. She currently serves on the editorial boards of Toxicology and Applied Pharmacology, Biology of Reproduction, and Experimental Biology and Medicine. In 2010, she organized the XVII International Ovarian Workshop. Dr. Hoyer has authored or coauthored 115 peer-reviewed scientific publications, 30 invited book chapters, and reviews in such texts as Comprehensive Toxicology and Casarett & Doull’s Toxicology. During her career, she has delivered numerous presentations at national/international meetings and symposia. She has trained over 25 Ph.D. and master’s students and postdoctoral fellows. These efforts have earned her the 2011 Trainee Mentoring Award for the Society for Study of Reproduction and the 2013 Mentoring Award for Women in Toxicology at the annual meeting of the Society of Toxicology.
"Overall, the book has remained focussed to its primary purpose and provides an excellent treatment of an important area of endocrine and reproductive toxicology …"
—Philip W. Harvey, Covance Laboratories Ltd, UK in bst News