Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery, 1st Edition (Hardback) book cover


Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery, 1st Edition

Edited by Chas Bountra, Rajesh Munglani, William K. Schmidt

CRC Press

968 pages

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Hardback: 9780824788650
pub: 2003-05-13
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This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

Table of Contents

Part 1: Basic Aspects 1. Mechanism-Based Classifications of Pain and Analgesic Drug Discovery 2. Sites of Analgesic Action 3. From Acute to Chronic Pain: Peripheral and Central Mechanisms 4. Central and Peripheral Components of Neuropathic Pain 5. A New Perspective on Signal Transduction in Neuropathic Pain: The Emerging Role of the G Protein βγ Dimer in Transducing and Modulating Opioid Signaling 6. Pain and the Somatosensory Cortex 7. Descending Pathways in Spinal Cord Stimulation and Pain Control 8. Local Neuroimmune Interactions in Visceral Hyperalgesia: Bradykinin, Neurotrophins, and Cannabinoids 9. Pain Processing in the Periphery: Development of Analgesics Part 2: Clinical Aspects 10. Neuroimaging of Pain: Possibilities of Objective Measurements of Analgesic Actions in Human Subjects 11. Surrogate Models of Pain 12. Acute Trauma and Postoperative Pain 13. Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes 14. Advances in the Management of Spinal Pain and Radiofrequency Techniques 15. Pulsed Radiofrequency Treatment of Chronic Neck, Back, Sympathetic, and Peripheral Neuroma-Derived Pain 16. Spinal Cord Stimulation 17. Spinal Endoscopy: Its Current Status and Role in Lumbosacral Radiculopathy 18. Cancer Pain Treatment 19. Inflammatory Joint Disease and Pain 20. Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen, Pelvis, and Bladder and Chronic Urogenital and Rectal Pain 21. Nerve Injury Pain 22. Sympathetically Maintained Pain 23. Headache: Basic Anatomy and Physiology of the Trigeminovascular System 24. Psychological Factors in Measurement of Pain 25. Challenges and Pitfalls of Clinical Trials: Evaluating Novel Analgesics for Neuropathic Pain Part 3: Novel Approaches to Drug Discovery 26. Molecular Approaches to the Study of Pain 27. Molecular Validation of Pain Targets 28. Genetics of Pain 29. Animal Models of Pain Part 4: New and Emerging Therapies 30. An Overview of Current and Investigational Drugs for the Treatment of Acute and Chronic Pain 31. Novel Mu, Delta, and Kappa Agonists: Potential for Development of Novel Analgesic Agents 32. Delta-Receptor, Nonpeptide Agonists: The Development of Safe, Strong Analgesics with a Novel Mechanism of Action 33. Peripheral Opioid Analgesia: Neuroimmune Interactions and Therapeutic Implications 34. Profile of ADL 2-1294, an Opioid Antihyperalgesic Agent with Selectivity for Peripheral Mu-Opiate Receptors 35. Controlled-Release Opioids 36. NMDA-Receptor Antagonists as Enhancers of Analgesic Activity: The MorphiDex™ Morphine–Dextromethorphan Combination 37. CCK Antagonist Potentiation of Opioid Analgesia 38. Profile of NSAID _ Opioid Combination Analgesics 39. NSAIDs and COX-2 Inhibitors 40. COX-2–Specific Inhibitors: Celecoxib and Second-Generation Agents 41. NK1 Receptor Antagonists: Potential Analgesics? 42. Vanilloids 43. The Development of Bradykinin Antagonists as Therapeutic Agents 44. The Treatment of Neuropathic Pain: Anticonvulsants, Antidepressants, Na Channel Blockers, NMDA Receptor Blockers, and Capsaicin 45. N-Methyl-D-Aspartate (NMDA) Receptors as a Target for Pain Therapy 46. Profile of Ketamine, CPP, Dextromethorphan, and Memantine 47. GV196771A, a New Glycine Site Antagonist of the NMDA Receptor with Potent Antihyperalgesic Activity 48. Voltage-Gated Sodium Channels and Pain: Recent Advances 49. Calcium Channel Antagonists and the Control of Pain 50. Profile of Ziconotide (SNX-111): A Neuronal N-Type Voltage-Sensitive 51. Calcium Channel Blocker 52. Nitric Oxide Synthase Inhibitors and the Role of Nitric Oxide in Nociception Adenosine and Pain 53. Adenosine Kinase Inhibition as a Therapeutic Approach to Analgesia 54. P2X Purinergic Receptors for ATP in Nociception 55. Somatostatin Receptors in Analgesia 56. Cannabinoids 57. Antinociceptive Effects of Centrally Administered Neurotrophic Factors 58. Peripheral Neurotrophic Factors and Pain 59. Profile of Tramadol and Tramadol Analogues 60. Sumatriptan and Related 5-HT1B/1D Receptor Agonists: Novel Treatments for Migraine 61. Cholinergic Approaches to Pain Therapy 62. Analgesic Effects of Vedaclidine, a Mixed Agonist–Antagonist at Muscarinic Receptor Subtypes 63. Gabapentin and Related Compounds 64. The Role of Gabapentin in the Management of Neuropathic Pain 65. New Local Anesthetic Analgesics 66. Spinal á2-Adrenergic Agonists for Intractable Cancer Pain 67. Cellular Implantation for the Treatment of Chronic Pain 68. Bone-Seeking Radiopharmaceuticals to Palliate Painful Bone Metastases

About the Author/Editors

Bountra\, Chas; Munglani\, Rajesh; Schmidt\, William K.

Subject Categories

BISAC Subject Codes/Headings:
HEALTH & FITNESS / Pain Management
MEDICAL / General
MEDICAL / Neurology
MEDICAL / Pharmacy