Parkinson's Disease: Genetics and Pathogenesis, 1st Edition (Paperback) book cover

Parkinson's Disease

Genetics and Pathogenesis, 1st Edition

Edited by Ted M. Dawson

CRC Press

408 pages

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Description

An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson’s Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. The book reviews the major aspects of the disease including motoric and pathologic features, autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations. It also provides an in-depth review of genetic considerations. With contributions by recognized experts on the topic, emphasis is placed on pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.



Table of Contents

OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism. Genetic Risk Factors for PD.

PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's Disease.

The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease. ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C. Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's Disease. Rotenone Model. Drug Trials in Animal Models of PD

About the Editor

Ted M. Dawson

Subject Categories

BISAC Subject Codes/Headings:
MED000000
MEDICAL / General
MED056000
MEDICAL / Neurology
MED057000
MEDICAL / Neuroscience
MED107000
MEDICAL / Genetics