Pathology of the Developing Mouse: A Systematic Approach, 1st Edition (Hardback) book cover

Pathology of the Developing Mouse

A Systematic Approach, 1st Edition

Edited by Brad Bolon

CRC Press

446 pages | 159 Color Illus. | 29 B/W Illus.

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pub: 2015-04-24
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Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity.

The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit:

  • baseline anatomic and physiologic traits of developing mice
  • principles of good experimental design and statistical analysis for mouse developmental pathology studies
  • procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques;
  • methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids;
  • options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and
  • well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).


"Pathology of the Developing Mouse: A Systematic Approach is a much anticipated addition to the veterinary pathology reference literature. It is a fairly inexpensive textbook that will be useful for anyone who uses mice in developmental research.

Detailed, easy-to-follow experimental protocols are described throughout the text. In many cases, there are multiple options for procedures with pros and cons discussed for each. Each chapter contains excellent tables, diagrams, and photographs and ends with a complete reference list.

Although there is a growing volume of information on mouse developmental biology in the literature and on the Internet, the authors of this book have done a great job of creating a synopsis of this information that can be easily used by anyone working or training in mouse pathology or developmental biology."

—Stephen M. Griffey, DVM, PhD, University of California–Davis, in JAVMA

Table of Contents


The Case for Developmental Pathology and Developmental Pathologists

Brad Bolon


Essentials of Mouse Genetics and Nomenclature

Oded Foreman and Brad Bolon

Essential Terminology for Mouse Developmental Pathology Studies

Brad Bolon and Colin G. Rousseaux

Anatomy and Physiology of the Developing Mouse and Placenta

Brad Bolon and Jerrold M. Ward

Teratogens and Teratogenic Mechanisms in Mouse Developmental Pathology

Brad Bolon and Colin G. Rousseaux


Principles of Experimental Design for Mouse Developmental Pathology Studies

Brad Bolon and Krista M.D. La Perle

Necropsy Sampling and Data Collection for Studying the Anatomy, Histology, and Pathology of Mouse Development

Susan Newbigging, Jerrold M. Ward, and Brad Bolon

Clinical Pathology Analysis in Developing Mice

Kelli L. Boyd, Brad Bolon, and Denise I. Bounous

Histotechnological Processing of Developing Mice

Brad Bolon, Diane Duryea, and Julie F. Foley

Localization of Gene Expression in Developing Mice

Jennifer M. Mele and Brad Bolon

Protein Localization in Developing Mice

Brad Bolon and Efrain Pacheco

Quantitative Morphological Assessment in Mouse Developmental Pathology Studies

Brad Bolon and Stephen Kaufman

Ultrastructural Evaluation of Developing Mice

Brad Bolon, Stephen Kaufman, and Richard Montione

Three-Dimensional Imaging in Mouse Developmental Pathology Studies

Brad Bolon, Kathleen Gabrielson, Sara Cole, Olga N. Kovbasnjuk, Kimerly A. Powell, and David Weinstein


Pathology of the Developing Mouse from Conception to Weaning

Brad Bolon and Vinicius Carreira

Pathology of the Placenta

Brad Bolon and Jerrold M. Ward

Mouse Developmental Pathology Assessments in High-Throughput Phenogenomic Facilities

Colin McKerlie, Susan Newbigging, and Geoffrey A. Wood

A Statistical Analysis Primer for Mouse Developmental Pathology Studies

Brad Bolon and Colin G. Rousseaux



About the Editor

Brad Bolon, DVM, MS, PhD, is a Diplomate of both the American College of Veterinary Pathologists (DACVP) and the American Board of Toxicology (DABT) as well as a Fellow of both the Academy of Toxicological Sciences (FATS) and the International Academy of Toxicologic Pathology (FIATP). He is currently an associate professor in the Department of Veterinary Biosciences, College of Veterinary Medicine and also the associate director of the Comparative Pathology and Mouse Phenotyping Shared Resource, Comprehensive Cancer Center at the Columbus campus of The Ohio State University (OSU). His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, neonates, and placentas) and toxicologic neuropathology.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Research
SCIENCE / Life Sciences / Biology / Developmental Biology
SCIENCE / Life Sciences / Neuroscience