Peptide Antibiotics: Discovery Modes Of Action And Applications, 1st Edition (Hardback) book cover

Peptide Antibiotics

Discovery Modes Of Action And Applications, 1st Edition

Edited by Christopher Dutton, Mark Haxwell, Hamish McArthur, Richard G. Wax

CRC Press

308 pages

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Hardback: 9780824702458
pub: 2001-12-04
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This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response.

Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including:

  • the distribution and classification of diverse antimicrobial peptides throughout nature

  • the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins

  • the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin

  • the genetic basis determining the production of bacterial peptide antibiotics

  • the potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agents

  • the use of nisin as a commercial food preservative

    With contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.

  • Table of Contents

    Introduction to the Peptide Antibiotics

    Harry W. Taber

    Sources of Antimicrobial Peptides

    Chemistry and Applications of Synthetic Antimicrobial Peptides

    David Andreu and Luis Rivas

    Lanthionine-Containing Bacterial Peptides

    Ulrike Pag and Hans-Georg Sahl

    Unmodified Peptide-Bacteriocins (Class II) Produced by Lactic Acid Bacteria

    Ingolf F. Nes, Helge Holo, Gunnar Fimland, Håvard Hildeng Hauge, and Jon Nissen-Meyer

    Insect Cationic Antimicrobial Peptides

    Charles Hetru, Jules A. Hoffmann, and Robert E. W. Hancock

    Mammalian Antimicrobial Peptides

    Charles L. Bevins and Gill Diamond

    Potential Applications of Peptides

    Exploitation of Lantibiotic Peptides for Food and Medical Uses

    Máire P. Ryan, Colin Hill, and R. Paul Ross

    Amphibian Antimicrobial Peptides

    Michael A. Zasloff


    Subject Categories

    BISAC Subject Codes/Headings:
    SCIENCE / Chemistry / General
    SCIENCE / Chemistry / Organic