Peptide and Protein Drug Analysis  book cover
1st Edition

Peptide and Protein Drug Analysis

ISBN 9780367399269
Published June 19, 2019 by CRC Press
904 Pages

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Book Description

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design.
Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.
Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis

  • discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability
  • analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology
  • examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods
  • highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry
  • demonstrates uses of unnatural mutagenesis and combinatorial chemistry
  • explores mass spectrometry, protein sequence, and carbohydrate analysis
  • illustrates bioassays and other new functional analysis methods
  • surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)
  • addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells
  • reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering
  • and more!
    Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemis

  • Table of Contents


    Practical Principles of Protein Design,
    Ronald E. Reid and Patrick L. Franchini
    Peptidomimetic and Nonpeptide Drug Discovery: Concepts, Strategies, and Technologies, Tomi K. Sawyer
    Structure Prediction and Molecular Modeling,
    Robin E. J. Munro and William R. Taylor
    Chemical Synthesis of Peptides, Henriette A. Remmer and Gregg B. Fields
    Chemical Synthesis of Proteins, Graham J. Cotton, Maria C. Pietanza, and Tom W. Muir
    Introduction of Unnatural Amino Acids into Proteins, Scott A. Lesley
    Combinatorial Chemistry and the Structure-Function Analysis of Proteins, Rachel L. Winston and Michael C. Fitzgerald
    Folding Polypeptides for Drug Production and Discovery, Elizabeth Strickland, Philip J. Thomas, and Ming Li
    Protein and Peptide Chemical and Physical Stability,
    Bernard N. Violand and Ned R. Siegel
    Bioinformatics and Computational Chemistry in Molecular Design: Recent Advances and Their Applications, Jin Li and Barry Robson

    Chemical Analysis

    High Pressure Liquid Chromatography of Peptides and Proteins, Marie-Isabel Aguilar
    Practical Aspects of Peptide and Protein Analysis by Capillary Electrophoresis, Nicole J. Munro, Andreas Hühmer, and James P. Lander
    Gel Electrophoresis of Peptides and Proteins, Michael J. Dunn
    Carbohydrate Analysis of Glycoproteins and Glycopeptides, Nigel Jenkins, Pir M. Shah, and Lorraine D. Buckberry
    Protein Sequence Analysis, Hsieng S. Lu, Lee Anne Merewether, and Michael F. Rohde
    Mass Spectrometry, Vic Garner

    Functional Analysis

    Protein and Peptide Immunoassays, Anthony B. Chen
    Pharmacogenomics, Ann K. Daly and Jane Grove
    Analysis of Polypeptide Bioactivity, David C. Wood, Q. Khai Huynh, and Joseph B. Monahan
    Pharmacokinetics and Pharmacodynamics of Protein Therapeutics, Rene Braeckman
    Approaches to Validating the Identity of Peptides and Proteins,
    Ian R. Tebbett and Nancy D. Denslow

    Structural Analysis

    Solution Structu

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    Ronald E. Reid