Peptide and Protein Drug Delivery  book cover
1st Edition

Peptide and Protein Drug Delivery

Edited By

Vincent Lee



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ISBN 9780824778965
Published November 19, 1990 by CRC Press
912 Pages

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Book Description

This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

Table of Contents

Series Introduction

Preface

Contributors

Part One

Fundamentals

Changing Needs in Drug Delivery in the Era of Peptide and Protein Drugs

Vincent H. L. Lee

Synthesis of Peptides and Proteins by Channnel and Biotechnological Means

Paul D. Gesellchen and Robert F. Santerre

Physical Biochemistry of Peptide Drugs: Structure, Properties, and Stabilities of Peptides Compared with Proteins

James Q. Oeswein and Steven J. Shire

Approaches to the Analysis of Peptides

Cynthia S. Randall, Thomas R. Malefyt, and Larry A. Sternson

Analysis of Protein Drugs

Rodney Pearlman and Tue H. Nguyen

Enzymatic Barriers to Peptide and Protein Drug Delivery

Vincent H. L. Lee, Robert D. Traver, and Mitchell E. Taub

Intestinal Epithelial and Vascular Endothelial Barriers to Peptide and Protein Delivery

Joffre Baker, Ismael J. Hidalgo, and Ronald T. Borchardt

Pharmacokinetics of Peptide and Protein Drugs

Udaya Bhaskar Kompella and Vincent H. L. Lee

Part Two

Routes of Delivery

Parental Delivery of Peptide and Protein Drugs

Partha S. Banerjee, Ehab A. Honsy, and Joseph R. Robinson

Buccal Routes of Peptide and Protein Drug Delivery

Hans P. Merkle, Reinhold Anders, Aloys Wermerskirchen, Susanne Raehs, and Gregor Wolany

Rectal Route of Peptide and Protein Drug Delivery

J. Howard Rytting

Nasal Route of Peptide and Protein Drug Delivery

Kenneth S. E. Su

Vaginal Route of Peptide and Protein Drug Delivery

Hiroaki Okada

Transdermal Route of Peptide and Protein Drug Delivery

Yie W. Chien

Oral Route of Peptide and Protein Drug Delivery

Vincent H. L. Lee, Satish Dodda-Kashi, George M. Grass, and Werner Rubas

Part Three

Pratical Considerations

Mucoadhesive Dosage Forms for Peptide and Protein Drug Delivery

Sau-Hung S. Leung, Tsuneji Nagai, and Yoshiharu Machida

Preformulation and Formulation Considerations of Peptide Drugs: Case History of and LHRH Analog

Shabbir T. Anik and David M. Johnson

Controlled Delivery Systems for Peptide

Lynda M. Sanders

Characterization of the Toxicity Profile of Peptide and Protein Therapeutics

B. J. Marafino, Jr., and J. R. Kopplin

Reduction of Imminogenicity and Extension of Circulating Half-Life of Peptides and Proteins

Frank F. Davis, Glen M. Kazo, Mary L. Nucci, and Abraham Abuchowski

Regulatory Prespective of Peptide and Protein Drug Development

John L. Gueriguian, Yuan-Yuan H. Chui, Alex Jordan, Carols A. Schaffernburg, and Solomen Sobel

Index

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Reviews

". . .extremely well written in terms of both clarity and organization of the material. . .. If you or your library does not already have a copy of this book, buy it immediately."
---Journal of Controlled Release
". . .provides exceptional detail."
---American Journal of Pharmaceutical Education
"An outstanding contribution to the field."
---Biomaterials