Percutaneous Penetration Enhancers  book cover
2nd Edition

Percutaneous Penetration Enhancers

  • This format cannot be shipped to your selected country.
ISBN 9780849321528
Published November 2, 2005 by CRC Press
448 Pages 121 B/W Illustrations

FREE Standard Shipping

Prices & shipping based on shipping country


Book Description

Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.

Table of Contents


Penetration Enhancer Classification, B.W. Barry

Structure–Activity Relationship of Chemical Penetration Enhancers, N. Kanikkannan, J.B. Ramapuram, and M. Singh

Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action, S.K. Li and W.I. Higuchi

The Role of Prodrugs in Penetration Enhancement, K.B. Sloan and S.C. Wasdo


Penetration Enhancement by Skin Hydration, J. Zhang, C.H. Purdon, E.W. Smith, H.I. Maibach, and C. Surber

Enhancement of Delivery with Transdermal Sprays, B.C. Finnin and J. Hadgraft

Hydrogel Vehicles for Hydrophilic Compounds, T. Cerchiara and B. Luppi

Enhanced Skin Permeation Using Ethosomes, E. Touitou and B. Godin

Microemulsions in Topical Drug Delivery, S. Pappinen and A. Urtti

Nanoparticles as Carriers for Enhanced Skin Penetration, S. Miyazaki

Solid Lipid Nanoparticles for Topical Delivery, Z. Mei

Fatty Alcohols and Fatty Acids, R.J. Babu, M. Singh, and N. Kanikkannan

Essential Oils and Terpenes, R.A. Thakur, Y. Wang, and B.B. Michniak


Iontophoresis: Clinical Applications and Future Challenges, N. Abla, A. Naik, R.H. Guy, and Y.N. Kalia

Electroporation, B.M. Medi and J. Singh

Micron, M.R. Prausnitz, J.A. Mikszta, and J. Raeder-Devens

Vesicles under Voltage, M.C. Bonner and B.W. Barry


Mechanistic Studies of Permeation Enhancers, S.K. Li and W.I. Higuchi

Penetration Enhancer Assessment by Corneoxenometry, C. Pie´rard-Franchimont, F. Henry, E. Uhoda, C. Flagothier, and G.E. Pie´rard

Assessment of Vehicle Effects by Skin Stripping, C.H. Purdon, C. Pellanda, C. Surber, and E.W. Smith

The Use of Skin Alternatives for Testing Percutaneous Penetration, C.S. Asbill, G.W. Bumgarner, and B.B. Michniak

High Throughput Screening of Transdermal Penetration Enhancers: Opportunities, Methods, and Applications, A. Jain, P. Karande, and S. Mitragotri

Confocal Laser Scanning Microscopy: An Excellent Tool for Tracking Compounds in the Skin, D.D. Verma and A. Fahr


Fundamentals of Retarding Penetration, J. Hadgraft and B.C Finnin

Retardation Strategies for Sunscreen Agents, C.H. Purdon, E.W. Smith, and C. Surber

Military Perspectives in Chemical Penetration Retardation, E.H. Braue, Jr., B.F. Doxzon, H.L. Lumpkin, K.A. Hanssen, R.S. Stevenson, R.R. Deckert, and J.S. Graham


Preclinical and Clinical Development of a Penetration Enhancer SEPA 0009, T.C. K. Chan


View More


"Thoroughly updated, this second edition is the most complete reference on the methods available in the field. … This edition contains comprehensive descriptions of the latest techniques, and several chapters deal with the modern analytical techniques adapted to assess and measure penetration enhancement. … This volume elegantly sums up current research in the ever-broadening fields of topical penetration, enhancement and retardation. It establishes a broad framework for the topic and a foundation for continued research." —In Anticancer Research, Vol. 26, 2006

"The book is an ideal and practical reference in Percutaneous Penetration Enhancers…designed for researchers, students, biomedical and pharmaceutical scientists." —International Journal of Biological Macromolecules, September 2006

"Overall, I thought the book was a very well put together review of the field of percutaneous enhancers. It will be used by both experienced academics and young researchers to bring themselves quickly up to date in their areas of interest." —IFSCC  Magazine, Vol. 11, No. 1, 2008