Personalized Medicine: Promises and Pitfalls, 1st Edition (Hardback) book cover

Personalized Medicine

Promises and Pitfalls, 1st Edition

By Gloria Gronowicz

Routledge

212 pages | 44 B/W Illus.

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Hardback: 9781498714914
pub: 2016-04-19
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Description

Personalized Medicine: Promises and Pitfalls broadly explores the tailoring of medical treatment to a patient’s characteristics, needs, and preferences during all stages of care, including prevention, diagnosis, treatment, and follow-up.

The book’s goal is to explain the science behind personalized medicine, what impact it may have on specific diseases, and some of the repercussions of a personalized medical approach on our medical institutions.

Novel personalized therapeutic treatments and their scientific basis are discussed by covering topics as diverse as genomics, proteomics, epigenetics, integrative medicine, stem cells, and the factors that influence personal health.

A personalized medical system also requires patient involvement in developing a healthy lifestyle, and so this book touches on topics such as the individual’s family history, present and past lifestyle, nutrition, exercise levels, and stress factors.

By explaining these broad topics in personalized medicine and the science behind them, we discover how personalized medicine can have a positive impact on an individual’s health.

Reviews

"This is an extraordinary book written by a research scientist to educate medical personnel and laypersons on the changes in molecular biology research and how the practice of medicine can benefit from that research… This is a uniquely important book, one that sets a milestone in understanding how science and medicine are progressing, bringing older practicing clinicians and their patients to an understanding of what medicine can offer now and a glimpse into what the future holds." - Vincent F Carr, DO, MSA, FACC, FACP(Uniformed Services University of the Health Sciences), Doody Enterprises

Table of Contents

Genomics

DNA

Chromosomes

Genes

Transcription and Translation

The Birth of Genetics with Mendel

Mitosis, Meiosis, and Recombination

Single-Nucleotide Polymorphism

Cystic Fibrosis, Cancer and Genomics

Post-Translational Modifications

Microarrays and CRISPR/Cas9

Chimera

References

Proteomics

Amino Acids and Proteins

Post-Translational Modifications

Biomarkers

Proteomics, Biomarkers, and Prostate Cancer

Metabolomics

Proteomics, Biomarkers, and Breast Cancer

Proteomics and Atherosclerosis

References

Epigenetics

Diabetes and Epigenetics

Diabetes and DNA Methylation

Histones and Epigenetics

Genomics, Epigenetics, and Environment in Mental Illnesses

miRNAs, siRNAs, and piRNAs

miRNAs and Cancer

miRNAs and Hepatitis C

References

Integrative Medicine: Nutrition and Exercise

Healthy Diet

BMI

Vitamins

Minerals in our Diet

Metabolic Syndrome, Cholesterol, Low-Density Lipoprotein, High-Density Lipoprotein, and Blood Pressure

Genetics, Obesity, and Healthy Diets

Weight Loss

Eating Healthy

Sugar-Sweetened Sodas

Physical Activity and Exercise

Poverty and Child Nutrition

References

Other Integrative Medical Treatments

Acupuncture

Stress

Stress Reduction

Mind–Body Therapies: Meditation, Mindfulness, Dr. John Kabat-Zinn, and Guided Imagery

Yoga

References

The Placebo Effect

Psychological Factors and Neurobiology

Hormone and Immune Responses

Placebo and Antidepressants

Placebo Effect, Survival Effects, and Other Questions

References

Stem Cells

Stem Cells in Medicine

Embryonic Stem Cells

Induced Pluripotent Stem Cells

iPSCs and Yamanaka Factors

Somatic Cell Nuclear Transfer

Scientific Problems to Be Solved for iPSCs

Present Use of iPSCs for Medicine

Stem Cells and Parkinson’s Disease and Macular Degeneration

References

Scientific Studies and Medical Trials

Case Reports

RCTs

Other Types of Medical Studies and the Issues with RCTs

Animal Studies

Cell Studies

Computer-Based Modeling

Peer Review of Medical and Scientific Studies Leading to Publication

References

Medical Training for Personalized Medicine

Genomics and the Medical School Curriculum

National Resources for Genomics Training

Collaboration across Medical Disciplines for Personalized Medicine

References

Drug, Hospital, and Medical Care Costs

Healthcare Costs

Drug Costs

What Ails Us

Adding Personalized and Preventative Medicine to our Healthcare System

Conclusions

References

Ethics

International and National Laws Protecting Patients

Privacy of Patient Records and the Health Insurance Portability and Accountability Act

Patient Autonomy, Well-Being, and Equity

Applicability of Personalized Therapeutics

Research Ethics

Artificial Intelligence

References

Conclusions

References

Glossary of Scientific Terms

About the Author

Gloria Gronowicz, PhD, is currently a professor in the Department of Surgery at the University of Connecticut Health Center in Farmington, USA. Dr. Gronowicz received her PhD in biological sciences from Columbia University and completed a postdoctoral fellowship at the University of Chicago. She has published more than 100 articles in peer-reviewed journals, ten book chapters and many scientific abstracts for national and international meetings. For more than 25 years, Dr. Gronowicz has had continuous NIH funding and has been funded by numerous scientific and medical foundations for her research. Her research interests include bone biology, osteoporosis, aging, the response of bone cells to implant materials, otosclerosis and integrative/complementary medicine.

Subject Categories

BISAC Subject Codes/Headings:
MED004000
MEDICAL / Alternative Medicine
MED078000
MEDICAL / Public Health
MED107000
MEDICAL / Genetics