1st Edition

Personalized Medicine Promises and Pitfalls

By Gloria Gronowicz Copyright 2016
    232 Pages 44 B/W Illustrations
    by Routledge

    Personalized Medicine: Promises and Pitfalls broadly explores the tailoring of medical treatment to a patient’s characteristics, needs, and preferences during all stages of care, including prevention, diagnosis, treatment, and follow-up.

    The book’s goal is to explain the science behind personalized medicine, what impact it may have on specific diseases, and some of the repercussions of a personalized medical approach on our medical institutions.

    Novel personalized therapeutic treatments and their scientific basis are discussed by covering topics as diverse as genomics, proteomics, epigenetics, integrative medicine, stem cells, and the factors that influence personal health.

    A personalized medical system also requires patient involvement in developing a healthy lifestyle, and so this book touches on topics such as the individual’s family history, present and past lifestyle, nutrition, exercise levels, and stress factors.

    By explaining these broad topics in personalized medicine and the science behind them, we discover how personalized medicine can have a positive impact on an individual’s health.

    Transcription and Translation
    The Birth of Genetics with Mendel
    Mitosis, Meiosis, and Recombination
    Single-Nucleotide Polymorphism
    Cystic Fibrosis, Cancer and Genomics
    Post-Translational Modifications
    Microarrays and CRISPR/Cas9

    Amino Acids and Proteins
    Post-Translational Modifications
    Proteomics, Biomarkers, and Prostate Cancer
    Proteomics, Biomarkers, and Breast Cancer
    Proteomics and Atherosclerosis

    Diabetes and Epigenetics
    Diabetes and DNA Methylation
    Histones and Epigenetics
    Genomics, Epigenetics, and Environment in Mental Illnesses
    miRNAs, siRNAs, and piRNAs
    miRNAs and Cancer
    miRNAs and Hepatitis C

    Integrative Medicine: Nutrition and Exercise
    Healthy Diet
    Minerals in our Diet
    Metabolic Syndrome, Cholesterol, Low-Density Lipoprotein, High-Density Lipoprotein, and Blood Pressure
    Genetics, Obesity, and Healthy Diets
    Weight Loss
    Eating Healthy
    Sugar-Sweetened Sodas
    Physical Activity and Exercise
    Poverty and Child Nutrition

    Other Integrative Medical Treatments
    Stress Reduction
    Mind–Body Therapies: Meditation, Mindfulness, Dr. John Kabat-Zinn, and Guided Imagery

    The Placebo Effect
    Psychological Factors and Neurobiology
    Hormone and Immune Responses
    Placebo and Antidepressants
    Placebo Effect, Survival Effects, and Other Questions

    Stem Cells
    Stem Cells in Medicine
    Embryonic Stem Cells
    Induced Pluripotent Stem Cells
    iPSCs and Yamanaka Factors
    Somatic Cell Nuclear Transfer
    Scientific Problems to Be Solved for iPSCs
    Present Use of iPSCs for Medicine
    Stem Cells and Parkinson’s Disease and Macular Degeneration

    Scientific Studies and Medical Trials
    Case Reports
    Other Types of Medical Studies and the Issues with RCTs
    Animal Studies
    Cell Studies
    Computer-Based Modeling
    Peer Review of Medical and Scientific Studies Leading to Publication

    Medical Training for Personalized Medicine
    Genomics and the Medical School Curriculum
    National Resources for Genomics Training
    Collaboration across Medical Disciplines for Personalized Medicine

    Drug, Hospital, and Medical Care Costs
    Healthcare Costs
    Drug Costs
    What Ails Us
    Adding Personalized and Preventative Medicine to our Healthcare System

    International and National Laws Protecting Patients
    Privacy of Patient Records and the Health Insurance Portability and Accountability Act
    Patient Autonomy, Well-Being, and Equity
    Applicability of Personalized Therapeutics
    Research Ethics
    Artificial Intelligence


    Glossary of Scientific Terms


    Gloria Gronowicz, PhD, is currently a professor in the Department of Surgery at the University of Connecticut Health Center in Farmington, USA. Dr. Gronowicz received her PhD in biological sciences from Columbia University and completed a postdoctoral fellowship at the University of Chicago. She has published more than 100 articles in peer-reviewed journals, ten book chapters and many scientific abstracts for national and international meetings. For more than 25 years, Dr. Gronowicz has had continuous NIH funding and has been funded by numerous scientific and medical foundations for her research. Her research interests include bone biology, osteoporosis, aging, the response of bone cells to implant materials, otosclerosis and integrative/complementary medicine.

    "This is an extraordinary book written by a research scientist to educate medical personnel and laypersons on the changes in molecular biology research and how the practice of medicine can benefit from that research… This is a uniquely important book, one that sets a milestone in understanding how science and medicine are progressing, bringing older practicing clinicians and their patients to an understanding of what medicine can offer now and a glimpse into what the future holds." - Vincent F Carr, DO, MSA, FACC, FACP(Uniformed Services University of the Health Sciences), Doody Enterprises