1st Edition

Pharmaceutical Biocatalysis Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

Edited By Peter Grunwald Copyright 2020
    862 Pages 65 Color & 297 B/W Illustrations
    by Jenny Stanford Publishing

    862 Pages 65 Color & 297 B/W Illustrations
    by Jenny Stanford Publishing

    This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

    Future Strategies for Commercial Biocatalysis

    Robert E. Speight and Karen T. Robins

    Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis

    Pedro Merino et al.

    Using a Recombinant Metagenomic Lipase for Enantiomeric Separation of Pharmaceutically Important Drug Intermediates

    Rakesh Kumar, Uttam Chand Banerjee, and Jagdeep Kaur

    Biotechnological Production of Prenylated Xanthones for Pharmaceutical Use

    Mariam Gaid et al.

    Chemoenzymatic Approaches Towards (S)-Duloxetine

    Danish Shahzad, Muhammad Faisal, and Aamer Saeed

    Synthesis of Antioxidants via Biocatalysis

    Salman Zafar

    Biocatalysts: The Different Classes and Applications for Synthesis of APIs

    Peter Grunwald

    Laccase-Mediated Synthesis of Novel Antibiotics and Amino Acid Derivatives

    Annett Mikolasch

    Hydrolytic Enzymes for the Synthesis of Pharmaceuticals

    Sergio González-Granda and Vicente Gotor-Fernández

    Ene-Reductases in Pharmaceutical Chemistry

    Katrin Hecht and Rebecca Buller

    Biocatalyzed Synthesis of Antidiabetic Drugs

    Andrés R. Alcántara

    Glucose-Sensitive Drug Delivery Systems Based on Phenylboronic Acid for Diabetes Treatment

    Li Zhao et al.

    Synthesis of Important Chiral Building Blocks for Pharmaceuticals Using Lactobacillus and Rhodococcus Alcohol Dehydrogenases

    Marion Rauter, Simon Krebs, Gotthard Kunze

    Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases

    Matthias Höhne, Philipp Matzel, and Martin Gand

    Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug

    Thomas Rucha, Elina Siirola, and Radka Snajdrova

    Halogenases with Potential Applications for the Synthesis of Halogenated Pharmaceuticals

    Georgette Rebollar-Pérez et al.

    Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450

    Giovanna Di Nardo and Gianfranco Gilardi

    Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases

    Jan Kiebist et al.

    Biocatalytic Synthesis of Chiral 1,2,3,4-Tetrahydroquinolines

    Yongzheng Chen, Liu Song, and Zhongqiang Wang

    New Strategies to Discover Non-Ribosomal Peptides as a Source of Antibiotics Molecules

    Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla, and Víctor López y López

    Enzyme Kinetics and Drugs as Enzyme Inhibitors

    Peter Grunwald


    Peter Grunwald