Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients, 1st Edition (Hardback) book cover

Pharmaceutical Biocatalysis

Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients, 1st Edition

Edited by Peter Grunwald

Jenny Stanford Publishing

900 pages

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Hardback: 9789814800808
pub: 2019-10-31
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Description

This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

Table of Contents

Future Strategies for Commercial Biocatalysis

Robert E. Speight and Karen T. Robins

Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis

Pedro Merino et al.

Using a Recombinant Metagenomic Lipase for Enantiomeric Separation of Pharmaceutically Important Drug Intermediates

Rakesh Kumar, Uttam Chand Banerjee, and Jagdeep Kaur

Biotechnological Production of Prenylated Xanthones for Pharmaceutical Use

Mariam Gaid et al.

Chemoenzymatic Approaches Towards (S)-Duloxetine

Danish Shahzad, Muhammad Faisal, and Aamer Saeed

Synthesis of Antioxidants via Biocatalysis

Salman Zafar

Biocatalysts: The Different Classes and Applications for Synthesis of APIs

Peter Grunwald

Laccase-Mediated Synthesis of Novel Antibiotics and Amino Acid Derivatives

Annett Mikolasch

Hydrolytic Enzymes for the Synthesis of Pharmaceuticals

Sergio González-Granda and Vicente Gotor-Fernández

Ene-Reductases in Pharmaceutical Chemistry

Katrin Hecht and Rebecca Buller

Biocatalyzed Synthesis of Antidiabetic Drugs

Andrés R. Alcántara

Glucose-Sensitive Drug Delivery Systems Based on Phenylboronic Acid for Diabetes Treatment

Li Zhao et al.

Synthesis of Important Chiral Building Blocks for Pharmaceuticals Using Lactobacillus and Rhodococcus Alcohol Dehydrogenases

Marion Rauter, Simon Krebs, Gotthard Kunze

Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases

Matthias Höhne, Philipp Matzel, and Martin Gand

Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug

Thomas Rucha, Elina Siirola, and Radka Snajdrova

Halogenases with Potential Applications for the Synthesis of Halogenated Pharmaceuticals

Georgette Rebollar-Pérez et al.

Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450

Giovanna Di Nardo and Gianfranco Gilardi

Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases

Jan Kiebist et al.

Biocatalytic Synthesis of Chiral 1,2,3,4-Tetrahydroquinolines

Yongzheng Chen, Liu Song, and Zhongqiang Wang

New Strategies to Discover Non-Ribosomal Peptides as a Source of Antibiotics Molecules

Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla, and Víctor López y López

Enzyme Kinetics and Drugs as Enzyme Inhibitors

Peter Grunwald

About the Editor

Peter Grunwald

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED058170
MEDICAL / Nursing / Pharmacology
MED071000
MEDICAL / Pharmacology
SCI086000
SCIENCE / Life Sciences / General
TEC059000
TECHNOLOGY & ENGINEERING / Biomedical