Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.
Table of Contents
Fermentative Production of Vitamin B6
Jonathan Rosenberg, Björn Richts, and Fabian M. Commichau
Exploring Alternative Taxol Sources: Biocatalysis of 7-β-Xylosyl-10-Deacetyltaxol and Application for Taxol Production
Wan-Cang Liu et al.
Molecular Farming through Plant Engineering: A Cost Effective Approach to Produce Therapeutic and Prophylactic Proteins
Prakash Narayana Reddy, Krupanidhi Srirama, and Vijaya R. Dirisala
Microbial Biotransformations in the Production and Degradation of Fluorinated Pharmaceuticals
Cormac D. Murphy and Aoife Phelan
Successful Screening of Potent Microorganisms Producing L-Asparaginase
Archana Vimal and Awanish Kumar
Biotransformation of Xenobiotics in Living Systems
Maja Đanić and Momir Mikov
Degradation of Pharmaceutically Active Compounds by White-Rot Fungi and Their Ligninolytic Enzymes
Muhammad B. Asif and Faisal I. Hai
Removal of Pharmaceutical Pollutions from Municipal Sewage Mediated by Laccases
Thomas Hahn et al.
Mechanism of Drug Resistance in Staphylococcus aureus and Future Drug Discovery
Ana Leticia Gori Lusa et al.
Genome Editing and Gene Therapies: Complex and Expensive Drugs
Epigenetic and Metabolic Alterations in Cancer Cells: Mechanisms and Therapeutic Approaches
Chi Chun Wong and Jun Yu
Peter Grunwald studied chemistry at the Universities of Saarbrücken and Hamburg, Germany. He graduated in the field of high-frequency spectroscopy and then became a staff member of the Institute of Physical Chemistry. After receiving his PhD in physical chemistry, he founded a biotechnology research group. He was appointed professor in 2001.