Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases, 1st Edition (Hardback) book cover

Pharmaceutical Biocatalysis

Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases, 1st Edition

Edited by Peter Grunwald

Jenny Stanford Publishing

774 pages | 34 Color Illus. | 74 B/W Illus.

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Hardback: 9789814800617
pub: 2019-07-09
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The relationship between biocatalysis and the different areas of pharmaceutics is discussed in volumes 4 to 6 of Pan Stanford Series on Biocatalysis.

Volume 4 provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, the main regulatory authorities, rare diseases and orphan drugs, the costs of drug development and therapies, and the use of enzymes in downstream processing of pharmaceuticals. Examples of therapeutic enzyme inhibitors discussed are carbonic anhydrase inhibitors together with their multiple drug interactions, carboxylesterase inhibitors and human diseases, and the application of (multifunctional) inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer’s disease. The text also covers engineered proteins and bioactive peptides as therapeutic formulations and fibrinolytic enzymes for thrombolytic therapy. Different chapters discuss the enzymes employed for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology.

Table of Contents

Pharmaceuticals: Some General Aspects

Peter Grunwald

Use of Enzymes in the Downstream Processing of Biopharmaceuticals

Duarte Miguel F. T. Prazeres

Therapeutic Use of Carbonic Anhydrase Inhibitors and Their Multiple Drug Interactions

Andrea Angeli and Claudiu T. Supuran

Fibrinolytic Enzymes for Thrombolytic Therapy

Swaroop S Kumar, Sabu Abdulhameed

Role of Engineered Proteins as Therapeutic Formulations

Khushboo Gulati and Krishna Mohan Poluri

Synthesis of bioactive peptides for pharmaceutical applications

Jaison Jeevanandam et al.

Cardiovascular Disease and Oxidative Stress

Marco Fernandes, Alisha Patel, and Holger Husi

Enzymatic Amino Acid Deprivation Therapies Targeting Cancer

Carla S. S. Teixeira et al.

Carboxylesterase inhibitors: Relevance for Pharmaceutical Applications

Li-Wei Zou abd Guang-Bo Ge

Molecular Aspects of the Activity and Inhibition of the FAD-containing Monoamine Oxidases

Rona R. Ramsay

Multifunctional Monoamine Oxidase and Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Ireen Denya, Sarel F. Malan, and Jacques Joubert

The Neurodegenerative Characteristics of Alzheimer’s Disease and Related Multi-Target Drug Design Studies

Hayrettin Ozan Gülcan, and Ilkay Erdogan Orhan

Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism

Cristiano Mota et al.

Cytochrome P450 Enzymes for the Synthesis of Novel and Known Drugs and Drug Metabolites

Sanjana Haque et al.

Cytochromes P450, Cardiovascular Homeostasis and Disease

Chin Eng Ong et al.

Protein Degradation Inducers SNIPERs and PROTACs against Oncogenic Proteins

Norihito Shibata et al.

Resistance Mechanisms of Tumor Cells

Rolf Marschalek

Biocatalytic Nanoreactors for Medical Purposes

Oscar González-Davis, Kanchan Chauhan, and Rafael Vazquez-Duhalt

Computer-Aided Drug Design for the Identification of Multi-Target Directed Ligands (MTDLs) in Complex Diseases: An Overview

Pravin Ambure and Kunal Roy

The Development of Improved Therapeutics through a Glycan-‘Designer’ Approach

Natalia G. Bednarska

On Biocatalysis as Resourceful Methodology for Complex Syntheses: Selective Catalysis, Cascades, and Biosynthesis

Andreas Sebastian Klein, Thomas Classen, and Jörg Pietruszka

About the Editor

Peter Grunwald studied chemistry at the University of Saarbrücken and the University of Hamburg, Germany, where he graduated in the field of high-frequency spectroscopy, and then became a staff member of the Institute of Physical Chemistry.

About the Series

Pan Stanford Series on Biocatalysis

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Clinical Medicine
MEDICAL / Pharmacology
MEDICAL / Toxicology
SCIENCE / Life Sciences / General