Pharmaceutical Biotechnology
A Focus on Industrial Application
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Pharmaceutical Biotechnology: A Focus on Industrial Application
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Book Description
Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to Pharmaceutical Biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with teaching in mind, this book allows teachers to have an easier time preparing their classes and providing students with a fluid and easy to read text. The reader is given easy to follow step-by-step stages of the development of new biopharmaceuticals, as well as allowing the optimization of existing production processes.
Table of Contents
Chapter 1 Fundamentals of Biotechnology,
Michele Vitolo
Chapter 2 Thermodynamics applied to biomolecules
Attilio Converti, Adalberto Pessoa Junior, Jonatas de Carvalho Silva, Rodrigo Lira De Oliveira and Tatiana Souza Porto
Chapter 3 Expression Systems for the Production of Therapeutic Recombinant Proteins
Amanda Mizukami, Adalberto Pessoa Junior, Kamilla Swiech
Chapter 4 Molecular Biology - Tools in Industrial Pharmaceutical Biotechnology
Gisele Monteiro
Chapter 5 Molecular Biology Tools - Techniques and Enzymes
Gisele Monteiro
Chapter 6 Bioinformatics applied to the development of biomolecules of pharmaceutical interest
Renata Bannitz Fernandes, Carlos Alexandre Breyer, Leonardo Schultz da Silva, Pedro Henrique Camargo Penna, Antônio Sergio Kimus Braz and Marcos Antonio de Oliveira
Chapter 7 Bioprocesses: Microorganisms and Culture Media
Ricardo Pinheiro de Souza Oliveira; Adalberto Pessoa Jr
Chapter 8 Sterilization in pharmaceutical biotechnology
Valéria C. Santos-Ebinuma, Fernanda de Oliveira, Nathalia V. dos Santos, Jorge F. B. Pereira, Adalberto Pessoa-Jr
Chapter 9 Kinetics of Cell Cultivation
Aldo Tonso, Adalberto Pessoa-Jr, Michele Vitolo
Chapter 10 Bioreactors: modes of operation
Inês C. Roberto; Adalberto Pessoa Jr, Aldo Tonso
Chapter 11 Agitation and Aeration: Oxygen Transfer and Cell Respiration
Aldo Tonso, Thiago Olitta Basso, Adalberto Pessoa Jr and Ricardo Pinheiro de Souza Oliveira
Chapter 12 Mammalian Cell Culture Technology
Patrícia Barros dos Santos, Patrícia Léo, Ricardo Pinheiro de Souza Oliveira e Marco Antonio Stephano
Chapter 13 Purification Process of Biomolecules
Adalberto Pessoa Junior and Beatriz Vahan Kilikian
Chapter 14 Lipopolysaccharides (LPS) Methods of quantification and removal from biotechnological products
André M. Lopes, Jorge F. B. Pereira, João V. D. Molino, Felipe R. Lourenço, and Adalberto Pessoa-Jr
Chapter 15 Enzymes: The Catalytic Proteins
Michele Vitolo
Chapter 16 Enzymes as Drugs and Medicines
Carlota de Oliveira Rangel Yagui, Michele Vitolo
Chapter 17 Aspects of the Immobilization Technique
Michele Vitolo
Chapter 18 Biomolecules in Analytical Methods
João Henrique Picado Madalena Santos, Carlos Miguel Nóbrega Mendonça, Francislene Andréia Hasmann, Adalberto Pessoa Jr
Chapter 19 Nanotechnology and Biopharmaceuticals
Alexsandra Conceição Apolinário, Valker Araujo Feitosa, João Henrique Picado Madalena Santos, Carlota de Oliveira Rangel-Yagui
Chapter 20 Biosafety applied in pharmaceutical and biotechnological processes
Camila Manoel Crnkovic, Celso Pereira Caricati, Ricardo Pinheiro de Souza Oliveira, Marco Antonio Stephano
Chapter 21 Pharmaceutical Quality System for biotechnology products
Laura de Oliveira Nascimento; Francisco Vitor Santos da Silva e Marco Antonio Stephano
Chapter 22 Techno-economic Evaluation of Biotechnological Processes and Pharmacoeconomic Analysis
Rafael da Gama Ferreira, Nicola Sgrignoli Fuganholi, Larissa Pereira Brumano, Adriano Rodrigues Azzoni, Sindelia Freitas
Chapter 23 Perspectives for Pharmaceutical Biotechnology
Michele Vitolo
Editor(s)
Biography
Dr. Adalberto Pessoa Jr., Full professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products, such as liquid-liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries.
Dr. Michele Vitolo, Full professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst), and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, Chemical, and food industries. [email protected]
Dr. Paul Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. Prof Long is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.