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3rd Edition

Pharmaceutical Dosage Forms - Tablets
Rational Design and Formulation




ISBN 9780849390159
Published June 3, 2008 by CRC Press
568 Pages 208 B/W Illustrations

 
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Book Description

Pharmaceutical Dosage Forms: Tablets, Third Editionis acomprehensive treatment of the design, formulation, manufacture, and evaluation of the tablet dosage form.  The ultimate goal of drug product development is to design a system that maximizes the therapeutic potential of the drug substance and facilitates its access to patients; Volume 2 focuses on the rational design, and formulation of a tablet and includes chapters with practical illustrations and formulation examples.

Table of Contents

Part I - Basics.  Intro to Formulation of Immediate Release Tablets.  Principles and Practice of Preformulation.  Stability.  Pharmacokinetics and Dosage Form Design.  Addressing Poorly Soluble Drug Substances.  Experimental Design and Multivariate Optimization Tools in Formulation and Process Development.  Expert Systems and Other AI Applications.  Part II - Formulation of Immediate Release Tablets.  Excipients.  Formulation of Specialized IR Tablets.  Part III - Formulation of Modified Release Tablets.  Types of Release Profiles and Delivery Objectives.  Swellable and Rigid Matrices.  Controlling Release through Coated Systems.  Osmotic Systems.  Complex (Combined) Systems for Release Profiles for Designed for Specific Drugs or Therapeutic Objectives.  Tableting of Multiparticulates

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