1st Edition

Pharmaceutical Emulsions and Suspensions
Second Edition, Revised and Expanded



ISBN 9780824703042
Published February 25, 2000 by CRC Press
660 Pages

USD $250.00

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Book Description

Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility.
This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs.
Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents.
Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions

  • discusses uses of macroemulsions and (submicron) microemulsions
  • illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles
  • investigates the application of self-emulsifying drug delivery systems (SEDDS)
  • introduces techniques for increasing drug solubility with nanosuspensions
  • addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions
  • surveys drug delivery by way of dermatological, follicular, and ocular routes
  • explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process
  • compares and contrasts monomeric and micellar adsorption at oil-water interfaces
  • and more!
    Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.
  • Table of Contents

    Basic Concepts

    Main Surfactants Used in the Pharmaceutical Field
    Gilberte Marti-Mestres and Françoise Nielloud
    Formulation Concepts for the Emulsion Maker
    Jean-Louis Salager
    Emulsion Properties and Related Know-how to Attain Them
    Jean-Louis Salager
    Suspensions Formulation
    Fernando González-Caballero and Juan de Dios García López-Durán

    Health Applications

    Emulsions as Drug Delivery Systems
    Katrin Buszello and Bernd W. Müller
    Parenteral Fat Emulsions: Structure, Stability, and Applications
    Jörn-Stefan Lucks, Bernd W. Müller, and Karsten Klütsch
    The Use of Topical Emulsions as Drug Delivery Systems
    Eric W. Smith, Christian Surber, and Howard I. Maibach
    Vesicles as a Tool for Dermal and Transdermal Drug Delivery
    J. A. Bouwstra
    Ophthalmic Emulsions and Suspensions
    M. Fabrizio Saettone, Boris Giannaccini, and Daniela Monti
    Administration of Emulsions to the Gastrointestinal Tract
    Duncan Q. M. Craig, Manisha J. Patel, and Marianne Ashford
    Dry Adsorbed Emulsions
    Michel Rollet and Jölle Bardon
    Nanosuspensions for the Formulation of Poorly Soluble Drugs
    R. H. Müller, C. Jacobs, and O. Kayser
    Pharmaceutical Suspensions and Their Applications
    V. Gallardo, M. A. Ruiz, and A. V. Delgado

    Tools and Methods for Experiments and Measurements

    Experimental Design in Emulsion and Suspension Formulations' Theocritical Aspects
    Roger Phan-Tan-Luu and Didier Mathieu
    Applications of Experimental Methodology to Emulsions and Suspensions
    Françoise Nielloud, Gilberte Marti-Mestres, and Hélène Maillols
    Rheology of Suspensions and Emulsions
    Maria Isabel Briceño
    Determination of Size Distributions of Sub-Micron Particle Dispersions by Photon Correlation Spectroscopy
    E. R. Pike

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    Reviews

    "
    ...there is no comprehensive and practical text available on [dealing with emulsions and suspensions] ...which focus on surfactants and formulations, notwithstanding the great demand. {This} book...remed[ies] this situation....
    ...the last part of Pharmaceutical Emulsions and Suspensions is devoted to experimental design. This methodology offers an excellent approach for the formulation of emulsions and suspensions. It reduces expenditure of time and money by limiting the number of manipulations while retaining a very high quality of information....
    ...an ideal resource.
    "- The Eastern Pharmacist, 2000

    ...provides an excellent and comprehensive overview of the subject and would be a valuable addition to the pharmaceutics' library. It will be of particular value to researchers wishing for practical suggestions and guidance in the field.
    - American Journal of Pharmaceutical Education, 2000

    ...a delightful and valuable compilation that is both timely and complete....
    Can this book be recommended? Absolutely, with total confidence. The publishers provide a hardcover book printed on good-quality paper with clear illustrations. This volume is quite up to their usual standard.
    -Pharmaceutical Technology, 2001

    "…significant and comprehensive…
    …chapters are highly readable and informative.
    "-Pharmaceutical Development and Technology

    "…very timely.
    …the content will be of value for years to come….
    I have no hesitation in recommending this volume to any newcomer to the field.
    "-Food and Bioproducts Processing