1st Edition
Pharmaceutical Photostability and Stabilization Technology
445 Pages
by
CRC Press
445 Pages
by
CRC Press
445 Pages
by
CRC Press
Also available as eBook on:
Based on a training course developed by Dr. Joseph T. Piechocki and other experts in this field whose contributions appear in this book for two International Meetings on the Photostability of Drugs and Drug Products, this text clarifies the guidelines set by the International Conference on Harmonization (ICH) and provides a comprehensive background in the scientific principles involved in... Read more
History of Pharmaceutical Photostability Development. The ICH Photostability Guideline: A Discussion of Experimental Conditions. Terminology. Basic Principles of Drug Photostability Testing. Spectra. Sources. Glasses, Filters, and Containers. Chemical Actinometry. Radiometry/Photometry. Sample Presentation for Photostability Studies: Problems and Solutions. Determining the Kinetics and Mechanism of a Photochemical Reaction. Unexpected Photochemistry in Pharmaceutical Products: A Review on the Role of Diluents, Excipients, and Product Components in Promoting Pharmaceutical Photochemistry. Chambers and Mapping. Current Methods for the Analytical Investigation of the Photodegradation of Active Pharmaceutical Ingredients and Products. Photostabilization by Packaging. Photostabilization of Solid and Semisolid Dosage Forms. Photostability Studies of Solutions and Methods of Preventing Photodegradation. Photostability of Cosmetic Screens. Photodegradation and Photoprotection in Clinical Practice.
Biography
Joseph T. Piechocki, Karl Thoma
