2nd Edition

Pharmaceutical Water System Design, Operation, and Validation, Second Edition

By William V. Collentro Copyright 2010
    478 Pages 146 B/W Illustrations
    by CRC Press

    A major new work on all aspects of water, the most used raw material ingredient in the pharmaceutical and biotechnology industries—used as an excipient in pharmaceutical formulations, as a cleaning agent, and as a separately packaged product diluent.

    Drawing on the author’s extensive field experience with more than 400 pharmaceutical and related water purification systems, the text’s numerous case studies illuminate the best and worst of water system design and operation.

    The expanded Second Edition also includes new chapters that discuss:

    • passivation and electropolishing
    • rouging
    • ozone systems and accessories
    • USP purified water and water for injection
    • individual component process and instrumentation diagram (P&IDs) with control interface
    • documentation and specification requirements
    • systems installation, start-up, and commissioning

    Impurities in raw water
    Pretreatment techniques
    Ion removal techniques—reverse osmosis
    Ion removal techniques—ion exchange
    Additional ion removal techniques
    Distillation and Pure Steam generation
    Storage systems and accessories
    Ozone systems and accessories
    Polishing components
    Distribution systems—design, installation, and material selection
    Controls and instrumentation
    System design and specification guidelines
    System installation, start-up, and commissioning
    System validation


    William V. Collentro

    "This second edition has been significantly revised and updated from the first edition. The author's extensive work experience in this field is reflected throughout the book, which will serve as an excellent reference for anyone involved in manufacturing pharmaceutical waters." - Doody's Review Service