Since the completion of the first edition of this book, major developments have occurred in the pharmaceutical industry that have shaped the field of near-infrared (NIR) spectroscopy. A new initiative from the U.S. Food and Drug Administration (FDA) to modernize regulations of pharmaceutical manufacturing and drug quality has helped position NIR spectroscopy as an effective tool for pharmaceutical testing. Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy: Second Edition reflects these developments and brings readers an up-to-date summary of how this technique is being applied to pharmaceutical manufacturing.
Providing comprehensive coverage of NIR spectroscopy, from theory, mathematics, application, and mechanics of NIR analysis, the book supplies ample references to facilitate further rese
Basic principles and theory. History. Early instrumentation. Spectroscopic theory. Light-particle interaction. Instrumentation. Filter-based instruments. Scanning grating monochromators. Interferometer-based instruments. Acousto-optic tunable filters. Photodiode arrays. Specialty and custom instruments. Optical parameter instrumentation. Strengths and shortcomings of traditional types of equipment. Blend uniformity analysis. Mixing. Discussion of reported work. Sampling and data handling. Segregation, Demixing, and Particle Size. Granulation, Drying, and Coating. Monitoring Granulation and Drying. Coating and Pelletization. Pharmaceutical assays. Qualitative analysis. Quantitative analysis. Determination of actives in tablets and capsules. Considerations for intact dosage form analysis. Validation issues. International conference on harmonization. Historical perspective. Medical applications. Blood glucose. Blood oxygenation. Tissue. Major organs. Blood chemistry. Fetuses and newborns. Cancer and precancer. Photon migration in tissues. Review articles. Index.