Pharmacogenomics of Alcohol and Drugs of Abuse: 1st Edition (Hardback) book cover

Pharmacogenomics of Alcohol and Drugs of Abuse

1st Edition

Edited by Amitava Dasgupta, Loralie J. Langman

CRC Press

252 pages | 8 B/W Illus.

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pub: 2012-04-23
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Description

Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in drug and alcohol response is vital for professionals working in rehabilitation programs. The same principles that are applicable for therapeutic drugs are also applicable for drugs of abuse. Pharmacogenomics can supplement traditional therapeutic drug monitoring, potentially predicting correct dosage before initiation of the drug therapy.

Applying these principles to testing and treatment, Pharmacogenomics of Alcohol and Drugs of Abuse discusses the role of the clinical laboratory in the practice of personalized medicine. With contributions from a range of experts, the book presents the genetic aspects of alcohol metabolism and other drugs including marijuana, cocaine, and amphetamines. In addition to basic pharmacogenomic aspects, the book addresses slate and trait markers of drugs of abuse so readers can consider setting appropriate biomarker tests in their clinical laboratory.

Table of Contents

Pharmacogenomics Principles and Molecular Mechanisms of Action of Alcohol and Abused Drugs

Christine L.H. Snozek and Loralie J. Langman

Alcohol: Use and Abuse

Amitava Dasgupta

Slate and Trait Markers of Alcohol Abuse

Joshua Bornhorst, Annjanette Stone, John Nelson, and Kim Light

Introduction to Drugs of Abuse

Larry Broussard and Catherine Hammett-Stabler

Pharmacogenomics of Amphetamine and Related Drugs

Steven C. Kazmierczak

Pharmacogenomics of Cocaine

Loralie J. Langman and Christine L.H. Snozek

Genetic Aspect of Marijuana Metabolism and Abuse

Pradip Datta

Genetic Aspect of Opiate Metabolism and Addiction

Jorge L. Sepulveda

Pharmacogenomics Aspects of Addiction Treatment

F. Gerard Moeller

Methodologies in Pharmacogenetics Testing

Jorge L. Sepulveda

Index

About the Editors

Amitava Dasgupta is a Professor of Pathology and Laboratory Medicine at the University of Texas-Houston Medical School. Loralie Langman is an Associate Professor of Laboratory Medicine at the Mayo Clinic, Rochester, Minnesota.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics