Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from simple plasma kinetics, multi-compartment models, nonlinear kinetics, plasma protein binding, pharmacodynamic models, turnover concepts, receptor binding, functional adaption and rebound, dose-response-time data analysis, inter-species scaling and a lot more. A substantial effort has been invested into the new pharmacokineticsand pharmacodynamics, including many new and updated Case Studies.
The text develops a logical, real-world approach to data and reasoning, showing the reader how to:
- Think both analytically and visually about data
- Use graphics to make a point
- Impove your pattern recognition ability
- Make sound decisions
- Strategize your data analyses
- Appreciate more fully the exciting field of Quantitative Pharmacology
Table of Contents
General Principles. Introduction. Basic Concepts. Why Model the Data? The Art of Successful Modeling. How to Use This Book. Pharmacokinetic Concepts. Pharmacodynamic Concepts. Modeling Strategies. Elements of Experimental Design. Pattern Recognition. Pharmacokinetic Applications. Pharmacodynamic Applications. References. Symbols and their definitions. Index.
"Going beyond mere numerics and calculations, this textbook helps the reader to become life-long learners exceeding the confines of a course. They will find that with little more PK/PD concepts, their daily professional lives will be more productive, understandable and creative."
--Book review by Elke H.J. Krekels